The BPC-157 peptide has shown promising beneficial effects in several areas of regenerative medicine. The following sections examine the potential benefits present in various studies. They cover various aspects and spheres of action of the formulation, from pharmacokinetics - how the body absorbs, distributes, metabolizes and excretes the peptide - to modulation of essential body processes.

What is the BPC-157?

The "body-protective compound 157," commonly referred to as BPC-157, is a peptide isolated mainly from human gastric juice. Composed of 15 amino acids, the compound exhibits a high molecular weight of 1419 Da. BPC-157, also known as BPC-15, BPC157, PL-10, PLD-116 or PL14736, shows remarkable therapeutic potential, especially in the treatment of severe trauma and stress injuries. It is known to promote the healing of various injuries and wounds, including ligaments, tendons and fractures [1, 2].

It has been found to provide significant benefits for the heart, liver, pancreas and muscle tissues, as well as the cornea and nervous system. What's more, its protective effect extends to the gastrointestinal tract, providing remarkable benefits to the esophagus, stomach, duodenum and colonic mucosa. In addition to its protective properties, BPC-157 also exhibits cytoprotective and anti-inflammatory properties, playing a key role in maintaining and preserving the integrity of epithelial tissues.

BPC-157 stability

BPC-157（乙酸盐）在室温下以粉末形式表现出高稳定性。进行了一项测试，结果表明，将醋酸盐形式的干燥肽在 50 摄氏度、65% 下储存 30 天，可产生 91.98% 的稳定性。需要注意的是，50 度对于蛋白质来说是一个非常高的温度。肽溶于水后，应贮存在冰箱中。对 BPC-157 肽在 50 摄氏度的水中进行了稳定性测试。肽在 65 小时后达到 55.25% 的稳定性。乙酸盐形式的 BPC-157 是最常用的注射盐，在人体胃环境中表现出中等稳定性。进行了一项测试，将乙酸盐形式的 BPC-157 置于 PH 2 的人胃环境中。肽在 30 分钟后的稳定性为 21.4%，1 小时后为 8.2%。在较高的 PH 值下获得更高的稳定性。对于 PH 3,30 分钟后为 41.7%，1 小时后为 26.1%。该肽在 PH 值为 4 时已经显示出相当好的稳定性，1 小时后稳定性结果为 90%。需要注意的是，胃的 PH 值通常在空腹时稳定在 2 左右，饭后上升到 3 左右。由此可以得出结论，除非胃的 ph 值升高到 4，否则 BPC-157 肽将被迅速消化。空腹睡前喝一杯水和一汤匙小苏打可以获得短期较高的胃 PH 值。BPC-157 的精氨酸盐形式要稳定得多，正是这种盐被认为适合口服。[5]

BPC-157 精氨酸盐的稳定性

在包括 50 摄氏度的高温在内的多种条件下测试了各种形式的 BPC-157 的稳定性。结果表明，BPC-157 的精氨酸盐，也称为 Arg-BPC，在这种高温下特别稳定。这意味着 Arg-BPC 可以在室温下安全储存而不会降解或失去功效 [5]。

传统上，BPC-157 是一种肽（一种蛋白质分子），被认为在胃液的酸性环境中不稳定并迅速降解。这种不稳定性在 BPC-157 的乙酸盐的情况下尤为明显。因此，它在胃中降解，导致生物利用度低，作为口服药物的疗效较低。

然而，测试表明，Arg-BPC 在胃液中比以前形式的 BPC-157（包括乙酸盐形式）稳定得多。这种增强的稳定性意味着一旦口服，Arg-BPC 就可以在胃的酸性环境中存活而不会太快分解，使其作为药物更有效。除了在胃中更好的稳定性外，Arg-BPC 在高温下也表现出更高的稳定性 [5]。这使其成为 BPC-157 的更稳健、更可靠的形式，适用于各种应用，尤其是口服给药。具体来说，BPC-157 在 50 摄氏度的水中放置 388 小时后显示出 99.01% 的稳定性。在人胃的环境中，它在 pH 值为 3 的 3 小时后显示出 90% 的稳定性。当 PH 值低于 3 时，肽的稳定性要差得多，因此建议饭后当胃的 PH 值等于或高于 3 时服用 [5]。

为什么 BPC-157 acetate 仅用于注射而不用于口服给药？BPC-157 制备为乙酸盐，已被证明存在稳定性问题，尤其是在暴露于胃的酸性环境中后。因此，BPC-157 acetate 通常通过注射而不是口服给药 [5]。

当 BPC-157 醋酸酯进入胃部时，胃液中的酸会导致它在被完全吸收之前分解并提供潜在的健康益处。这限制了其作为口服药物的有效性 [5]。因此，为了绕过胃的急性酸性环境，BPC-157 acetate 通常通过注射给药。这条直接途径确保它进入血液，而不会事先在胃中降解。

肽 BPC-157 鼻吸收。BPC-157 的分子量为 1419 Da。这意味着 BPC-157 分子与 Semax 的 813.93 Da 相比相对较大。Semax 在研究中经证实，鼻内给药时具有效果。据信，1419 Da 的粒径进一步允许鼻腔吸收，但吸收效果更差。解决方案可能是将稳定的 BPC-157 arg 肽溶解在盐水中，并加入 3% DMSO。添加 DMSO 可以吸收通常不会被吸收的更大分子。

BPC-157 剂量方法

BPC-157 有多种给药形式，包括口服、鼻内、局部和肠外给药 [3]。注射剂型因其物质的直接运输和快速吸收而被广泛使用。但是，也可以使用其他形式，例如鼻喷雾剂和胶囊。鼻腔气雾剂提供了非侵入性应用的便利性，而胶囊可以口服。这使得它们成为那些对注射不舒服的人来说更加用户友好的选择。每种形式的有效性可能取决于特定的使用场景、个人偏好和与给药方法相关的整体舒适度。

BPC 的药代动力学

BPC-157 的药代动力学或肽在体内的代谢方式已被广泛研究 [4]。以下是一些主要发现的简化摘要：

• BPC-157 不会在体内停留太久。它的“半衰期”，即一半产品离开身体所需的时间，不到 30 分钟。这对于由肽制成的物质来说是典型的。
• 该制剂在体内的行为是可预测的，表现出“线性药代动力学”，这意味着在所有测试剂量下，其作用与剂量成正比。
• 当注射到肌肉中时，BPC-157 在短短 9 分钟内非常迅速地达到血液中的最高浓度。
• 与单次注射相同剂量相比，在 7 天内多次服用 BPC-157 不会显着改变身体处理产品的方式。
• 通过肌肉注射给药时，进入血液以产生活性作用的物质百分比（称为“生物利用度”）在大鼠中为 14%-19%，在比格犬中为 45%-51%。
• 与其他肽制剂一样，身体主要通过肝脏和肾脏清除 BPC-157。
• BPC-157 分布于各种身体组织中，与血液相比，BPC-157 在肾脏、肝脏、胃壁、胸腺（产生免疫细胞的小器官）和脾脏中的含量更高。
• 最后，BPC-157 被分解或“代谢”成一种称为脯氨酸的单一氨基酸，这种氨基酸可以在血液、尿液和粪便中找到。

BPC-157 的剂量

BPC-157 的剂量推荐通常来自对大鼠的研究，因为这些研究中的大多数都使用口服给药，这已被证明是有益的。然而，重要的是要注意，由于新陈代谢、生理学和生物体大小的差异，将剂量从动物直接转化为人类并不总是准确的。大鼠有效口服剂量为 10 μg/kg 相当于人类估计剂量为 1.6 μg/kg。因此，根据这些研究，BPC-157 对不同体重个体的估计剂量为 [6]：

• For a person weighing 70 kg, the estimated dose would be about 110 μg.
• For a person weighing 90 kg, the dose increases to about 145 μg.
• For a person weighing 115 kg, the recommended dose would be about 180 μg.

In other studies, the recommended dose for BPC-157 is usually around 200 mcg (micrograms). This dose is usually administered by subcutaneous injection to ensure optimal absorption and efficacy.

Note that these are estimates, and the optimal dose may vary depending on individual factors. In Practice, BPC-157 peptide is very often used by bodybuilders for various injuries and trauma. They use doses of about 500mcg per day spread over 2 doses, it is believed that these dosages are the most effective.

Potential health benefits of BPC-157: Therapeutic agent for various conditions

BPC-157 has demonstrated tremendous health benefits. The following sections provide an easy-to-understand overview of these potential benefits, including its functions, the mechanisms it uses, and the types of experiments conducted to evaluate its effects.

BPC-157 and the central nervous system

BPC-157 provides potential benefits to the brain and nervous system [7]. It works in several ways, including changing the way certain genes in the body work, interacting with the nitric oxide system and helping the body recover from injury.

• Stroke:In some animal experiments, such as on rats, researchers administered BPC-157 to rats after they experienced a stroke. By giving BPC-157 to the rats, the researchers found that it helped repair damage to the brain's neurons, the cells that transmit information in the brain [7, 8].

BPC-157 also helped restore functions such as memory, movement and coordination, and seemed to affect certain genes in a part of the brain called the hippocampus, which plays an important role in memory formation.

• Schizophrenia and catalepsy: In other experiments, BPC-157 has also been shown to help manage symptoms similar to schizophrenia and catalepsy. Catalepsy is a condition in which a person can be stuck in one position for long periods of time, while schizophrenia is a serious mental disorder that affects the way a person thinks, feels and behaves. These benefits have been achieved by BPC-157 managing the action of the nitric oxide system in combination with various substances that affect dopamine, which is a chemical in the brain that plays a major role in the sensation of pleasure [7].
• Spinal cord injury: What's more, the researchers found that when BPC-157 was administered to rats with spinal cord compression (a serious injury that can lead to paralysis), it helped them recover and counteracted the paralysis of their tails. BPC-157 also helped treat brain disorders, reduce inflammation and promote nerve regeneration and blood vessel function after injury [7, 9, 10].
• BPC-157 versus the GABA system: BPC-157 interacts with the GABA system. GABA stands for gamma-aminobutyric acid, a type of natural sedative in our bodies. It helps regulate many behaviors and reactions, including some related to the functions of an area of the brain called the striatum [7, 53].

Some disorders of the GABA system, such as those caused by the use of drugs such as diazepam, can lead to increased tolerance (needing more of a drug to get the same effect) or withdrawal symptoms. Interestingly, BPC-157 can counteract these disorders, making it a possible treatment option for such problems. For example, with regard to diazepam, BPC-157 has been shown to counteract the development of tolerance and dependence on the drug, which are important side effects of long-term diazepam therapy.

In addition, BPC-157 exhibits anticonvulsant activity, meaning it can help prevent seizures or reduce their severity. This is another potential benefit, especially for people struggling with diseases characterized by seizures [7, 53].

These experiments suggest that BPC-157 may provide new treatments for a range of disorders in the central nervous system, which includes the brain and spinal cord.

BPC and the musculoskeletal system

BPC-157 has significant potential in the treatment of various musculoskeletal injuries [11]. Among others:

• Tendons and ligaments: Connective tissues, which link muscles to bones and joints, heal slowly due to limited blood supply. However, studies in rats have shown that BPC-157 can speed up this healing process. In experiments in which Achilles tendons were intentionally damaged, administration of BPC-157 resulted in significantly better regeneration, leading to stronger and healthier tendons, as seen in microscopic analysis [12]. Moreover, these effects were not limited to the Achilles tendon; similar improvements were also observed in other tendons and ligaments. The route of administration, oral, topical or intraperitoneal, does not appear to affect the efficacy of the peptide, suggesting a wide range of potential therapeutic applications [11, 13].

• Skeletal muscle injuries: In addition to ligaments and tendons, studies have shown a role for BPC-157 in the healing of skeletal muscle injuries. For example, in experiments in which the quadriceps muscle was intentionally cut in rats, systemic administration of BPC-157 promoted continuous healing for 72 days [14]. Moreover, it helped maintain functional recovery of the muscle, suggesting significant therapeutic potential.
• Muscle healing:The beneficial effects of BPC-157 were also observed in cases where healing was otherwise impaired due to corticosteroid treatment. The peptide not only induced a faster rate of healing, but also helped restore full muscle function [15].

Possible mechanisms

For musculoskeletal benefits, the possible mechanism of action of BPC-157 includes [11-17]:

• Activation of the FAK-Paxillin pathway: BPC-157 appears to promote the growth and movement of tendon cells. This is important because these cells play a major role in repairing damaged tendons.
• Effects on cell composition: BPC-157 appears to alter the balance of cells involved in healing. It increases the number of some helpful cells and decreases the number of some potentially harmful ones. This change is believed to promote better healing and the formation of collagen fibers, a key component of our tendons.
• Resistance to corticosteroid-induced impairment: BPC-157 may also help muscle healing, even in the presence of substances that slow healing (such as corticosteroids). This can be very important for people undergoing certain types of treatment.
• Reduction of proteolysis: BPC-157 can slow down the breakdown of proteins in our muscles. This can be helpful in situations where we are trying to heal a muscle injury.
• Supporting the growth of new blood vessels: BPC-157 can promote the growth of new blood vessels. This is a key part of the healing process, as it brings more nutrients to the damaged area and helps remove metabolic products. The substance appears to enhance this process by increasing the activity of certain molecules that stimulate blood vessel growth.
• Growth hormone receptor regulation: BPC-157 can also increase growth hormone receptor activity. This receptor interacts with growth hormones, which can stimulate cell growth and reproduction. If this receptor is more active, it can lead to better healing.

These potential mechanisms of action of BPC-157 hold promise as a therapeutic agent for various musculoskeletal injuries, potentially offering a new approach to improving healing and recovery in these areas.

BPC-157 and the brain: Potential neuroprotective ability

• Brain injuries: BPC-157 shows potential in treating brain injuries. In a study conducted on mice, the use of BPC-157 reduced the level of brain damage and the severity of bleeding and cuts in the brain. The product also helped reduce brain swelling. When BPC-157 was administered just before or immediately after injury, it improved the recovery process, leading to better consciousness and a lower death rate in mice [18, 19].
• Swelling and damage to the brain and damage to peripheral organs:In another study, BPC-157 was shown to help a complex syndrome that included swelling of the brain and damage to the brain and other organs. BPC-157 helped alleviate problems caused by blocked blood vessels in both the brain and other parts of the body. It can reduce brain swelling and normalize increased pressure in the brain. This study suggests that BPC-157 may have broad benefits in dealing with blood vessel blockages and related symptoms [20-22].

BPC-157 and cardiovascular health

• BPC-157 and heart failure: In animal studies with heart failure, a condition in which the heart cannot pump enough blood to meet the body's needs, BPC-157 helped relieve symptoms such as an enlarged heart, changes in the heart and congestion in the heart. The compound was also able to counteract heart failure conditions caused by harmful substances such as alcohol or lithium, or physical issues such as blocked bile ducts or increased abdominal pressure. Researchers believe that these benefits may be due to BPC-157's interaction with certain biological systems and its ability to protect cells from damage [23].
• BPC-157 and heart attacks/myocardial infarction

Studies have shown that BPC-157 can help treat heart attacks in laboratory animals. After administration of BPC-157, the animals showed less heart damage and their hearts continued to function well. The compound also helped prevent blood clotting and irregular heart rhythms while protecting the brain [24]. These benefits were seen regardless of how BPC-157 was administered, suggesting that it may be a promising treatment for heart attacks and related conditions.

• BPC-157 and blood clots: BPC-157 has also been shown to be beneficial in dealing with harmful blood clotting events. In various animal studies, the compound was effective in reducing blood clotting in both arteries and veins. It also helped maintain the function of platelets, cells that help blood clot, even in the presence of drugs that inhibit clotting. The effect on blood clotting may be related to BPC-157's ability to interact with and protect the lining of blood vessels and its effect on the nitric oxide system, a system involved in many processes in the body, including the regulation of blood flow [25].
• BPC-157 and blood pressure problems: BPC-157 has shown potential in dealing with serious blood pressure disorders, such as very high blood pressure in the cranial, portal and vena cava (major blood vessels in the body) and very low blood pressure in the main artery (aorta). It was also effective for severe blood volume loss and low blood pressure [26, 27]. Interestingly, the compound had no effect on normal blood pressure, suggesting that its action is aimed at resolving specific abnormal conditions rather than regulating blood pressure in general.
• BPC-157 and irregular heart rhythm: BPC-157 has shown promise in treating irregular heart rhythm (arrhythmias) in various experimental conditions, including heart attacks and heart failure. It may have an effect on arrhythmias by affecting the action of nitric oxide, a compound in the body that has a protective effect on the heart [28]. Further research is needed to fully understand how BPC-157 can help treat arrhythmias and related conditions.
• BPC-157 versus bleeding and thrombocytopenia: In a study in rats, the BPC-157 peptide showed potential in controlling excessive bleeding and counteracting low platelet counts, a condition called thrombocytopenia. The study used BPC-157 in rats with tail amputation and showed promising results by reducing bleeding time [29]. This opens up possibilities for BPC-157 to help in conditions where control of bleeding is crucial. The experiment was conducted in rats and we look forward to human studies to confirm these findings.
• BPC-157 and intra-abdominal tightness syndrome: Intra-abdominal tightness syndrome, a severe condition in which pressure builds up in the abdominal cavity, was shown to be significantly reversed by the administration of BPC-157 in rat studies. The treatment effectively improved blood flow, reducing swelling and congestion in various organs and reversing the deleterious events usually associated with the syndrome. BPC-157 even showed potential in resolving cardiac arrhythmias in these rats [30]. These findings suggest the potential of BPC-157 as a treatment for intra-abdominal tightness syndrome.
• Role of BPC-157 in vascular occlusion and organ dysfunction

BPC-157 showed significant effects against vascular obstruction and organ dysfunction. In the case of vascular obstruction, the peptide promoted the recruitment of collateral vessels that provide blood flow beyond the site of obstruction. This action led to a reduction in hypertension and improvement in ECG abnormalities. The use of BPC-157 also led to the almost complete elimination of venous and arterial thrombosis. Finally, the formulation helped alleviate lesions and dysfunctions of many organs [31].

BPC-157 and psychological conditions/neural transmitters

• BPC-157 and depression: The potential antidepressant effect of the gastric pentadecapeptide BPC-157 was studied in two rat models of depression, namely the forced swimming test and chronic unpredictable stress [32]. In the forced swimming test, BPC-157 treatment resulted in reduced immobility time, similar to conventional antidepressants. When subjected to a model of chronic unpredictable stress, in which the efficacy of conventional antidepressants often declines, BPC-157 consistently showed antidepressant effects. The conventional antidepressant imipramine typically required a longer period of administration to show its effect, but BPC-157 reduced immobility after both short-term and long-term treatment.

These findings suggest that BPC-157 may have antidepressant properties, indicating its potential as a therapeutic option for treating depression.

• BPC-157 and serotonin syndrome: Serotonin syndrome is a condition that often occurs due to monoamine oxidase (MAO) inhibition and serotonin (5-HT) exposure. In experimental studies with rats, BPC-157 showed significant beneficial effects. It counteracted or did not affect the onset of serotonin syndrome [33]. The beneficial effects were particularly evident in cases of severe serotonin syndrome, where BPC-157 was able to inhibit disorders associated with 5-HT2A receptor stimulation.
• BPC-157 and its anti-anxiety effects: In a study examining the anti-anxiety or anxiety-reducing effects of BPC-157, the peptide's effects were compared with those of diazepam [34]. The results showed that rats treated with BPC-157 exhibited a reduced fear response. Moreover, the effects of BPC-157 were different and distinct from those of diazepam, suggesting that it may offer a new approach to dealing with anxiety.
• Serotonin modulation: BPC-157 modulates serotonin levels in various brain regions [35]. The product affects serotonin production in the dorsal thalamus, hippocampus, hypothalamus, reticular black matter and medial frontal olfactory nucleus, which is extremely important for processing sensory information, managing emotions, controlling voluntary movements and our sense of smell. By subtly altering serotonin production in these specific areas, BPC-157 can provide various health benefits.

Role of BPC-157 in drug toxicity or overdose

BPC-157 has shown beneficial effects in counteracting toxicity caused by various drugs and chemicals. Its wide range of protective effects are observed in various preclinical studies, and its use is seen as promising in managing drug-induced toxicity.

• BPC-157 versus digitalis toxicity: Digitalis toxicity can occur due to overuse of heart disease drugs, leading to complications such as irregular heartbeat. Preclinical studies have shown that BPC-157 therapy can prevent or even reverse this toxicity. In rats, BPC-157 has been found to reduce cardiac arrhythmias, shorten the duration of heart block, and even counteract complications from drug interactions [36].
• Treatment of hyperkalemia with BPC-157: Hyperkalemia refers to abnormally high levels of potassium in the blood, which can lead to serious health complications. BPC-157 therapy has shown promise in treating this condition by preventing arrhythmias (irregular heartbeats) and restoring normal heart rhythm [7]. The therapy has also shown its potential in counteracting disorders such as muscle weakness and hypertension caused by hyperkalemia.
• The role of BPC-157 in counteracting the effects of succinylcholine: Succinylcholine is a neuromuscular blocker often used in anesthesia that can cause serious side effects, including hyperkalemia, cardiac arrhythmias and muscle spasms. BPC-157 effectively antagonized these effects, showing promising signs as a potential antidote to succinylcholine-induced adverse effects [37].
• BPC-157 in the treatment of furosemide-induced hypokalemia: Hypokalemia, a condition in which blood potassium levels are too low, can cause life-threatening cardiac arrhythmias [7]. The condition can be triggered by certain drugs, such as furosemide. BPC-157 therapy has been found to prevent arrhythmias associated with hypokalemia and eliminate fatal outcomes, demonstrating its potential as an effective treatment option.
• BPC-157 versus local anesthetics: Lidocaine, a local anesthetic, can cause a number of side effects, such as cardiac arrhythmias, seizures and cell depolarization [7]. BPC-157 has been shown to counteract these effects, making it a potential antidote to lidocaine-induced complications.
• BPC-157 versus QT interval prolongation: QT interval prolongation is a heart rhythm disorder that can lead to serious cardiac arrhythmias. Some drugs, such as neuroleptics (used to treat mental illness) and prokinetics (used for gastric diseases), can cause this prolongation [38]. BPC-157 therapy has shown the ability to counteract this effect, making it a potential treatment for this condition.
• BPC-157 and radiation-induced liver damage: Studies in mice have shown that BPC-157 can help reduce the damage done to the liver by radiation exposure. After radiation exposure, mice that received oral BPC-157 showed less liver damage than those that received no treatment [39]. This suggests that BPC-157 could potentially be used to protect the liver in individuals who must undergo radiation therapy.
• BPC-157 vs. harmful side effects of NSAIDs: NSAIDs are a type of drug that can sometimes cause serious side effects, such as damage to the stomach, intestines and liver. Studies have shown that BPC-157 can provide strong protection against these side effects [40]. This means that BPC-157 can be a valuable addition to treatment plans for people who need to take NSAIDs but are concerned about potential side effects.
• BPC-157 a negative effect of high doses of lithium:High doses of lithium can cause a number of health problems. However, studies in rats suggest that BPC-157 may help reduce these negative effects [41]. This indicates that BPC-157 may be a potentially useful therapy for people who need to take high doses of lithium and are concerned about the associated health risks.
• BPC-157 and liver damage caused by chronic alcohol consumption: Regular heavy alcohol consumption can lead to liver damage and high liver blood pressure. Studies in rats have shown that BPC-157 can help counteract these harmful effects [42]. This suggests that BPC-157 may be a potential therapy for people who have experienced liver damage due to chronic alcohol consumption.
• Cardiotoxicity of bupivacaine: Bupivacaine is a local anesthetic that can have toxic effects on the heart in high doses. BPC-157 has shown that it can counteract this toxicity, reducing harmful cardiac effects and preventing deaths in rats from bupivacaine overdose [43]. This suggests that BPC-157 may serve as an antidote to the cardiotoxicity of bupivacaine.
• BPC-157 and the effects of too much magnesium: In rat studies, BPC-157 was found to be effective in reducing the harmful effects of excess magnesium, such as severe muscle weakness and brain lesions [44]. This suggests that BPC-157 may be a potential therapy for people who have experienced the negative effects of too much magnesium.
• BPC-157 a paracetamol overdose: In cases of severe paracetamol (also known as Tylenol) overdose, BPC-157 has shown potential benefits. In animal studies, administration of BPC-157 after a paracetamol overdose helped prevent or quickly alleviate seizures (uncontrolled body tremors) and reduced liver and brain damage. It also helped lower levels of some markers signaling liver damage [45].
• BPC-157 a painkiller overdose: BPC-157 has shown potential in counteracting the harmful effects of NSAIDs and painkillers such as paracetamol. These include stomach and liver injuries and even brain damage. BPC-157 has been found to mitigate or even eliminate these effects in animal studies. Although the exact mechanisms of action of BPC-157 are not clear, it likely promotes healing and reduces inflammation at the cellular level. Additionally, it reduced behavioral disturbances and weight loss in rats treated with ibuprofen [46].
• BPC-157 versus insulin overdose: Another important advantage of BPC-157 is its ability to deal with the effects of insulin overdose. In animal studies, when BPC-157 was administered immediately after an insulin overdose, it helped prevent fatal outcomes, reduced seizures, minimized liver damage and reduced brain damage. The product also helped maintain normal blood sugar levels and minimize gastric damage [47].
• BPC-157 versus chronic ibuprofen use: BPC-157 has also shown potential in counteracting the negative effects of long-term ibuprofen use. The protein helped counteract many of the harmful effects associated with chronic ibuprofen use, including liver damage, stomach ulcers and liver swelling. It also helped minimize the harmful effects of ibuprofen on the brain, such as swelling and nerve cell damage [48].
• BPC-157 and amphetamine-related disorders: In a study involving rats, BPC-157 showed promising results in dealing with the behavioral effects of amphetamine. Rats treated with BPC-157 showed reduced abnormal excitability and behaviors typically associated with amphetamine use, suggesting that BPC-157 may help manage the effects of chronic amphetamine use [49].

BPC-157 has demonstrated a wide range of beneficial effects in counteracting the toxicity of various drugs and chemicals. These findings are largely based on preclinical studies, and further research is needed to fully understand their potential.

BPC-157: Potential help for gastrointestinal health

• Alleviating inflammatory bowel disease and multiple sclerosis:BPC-157 peptide has shown potential benefits for people suffering from inflammatory bowel disease (IBD) and multiple sclerosis (MS), which are chronic, debilitating conditions. According to animal studies, BPC-157 was administered orally or by injection, leading to significant improvements in healing rates of IBD conditions such as colitis. Moreover, when tested on animals with a simulated form of multiple sclerosis, BPC-157 helped protect areas of the brain from nerve damage, potentially slowing the progression of the disease [50].
• Treatment of short bowel syndrome:Short bowel syndrome is a difficult condition in which the body has difficulty absorbing enough nutrients due to inadequate function of the small intestine. In a study involving rats with this condition, BPC-157 was administered orally or by injection. The results showed that rats treated with BPC-157 experienced not only weight gain (a positive sign in this context), but also an improvement in the overall structure of the remaining intestines [51]. This could potentially indicate that BPC-157 helps the body better adapt to the loss of the intestine and improve nutrient absorption, offering hope to those struggling with this difficult condition.
• Repair of injuries to the cecum (part of the large intestine): For injuries to the cecum, which is an organ at the beginning of the large intestine, BPC-157 is again showing promise. Animal studies suggest that BPC-157 can improve healing by encouraging the growth of new blood vessels in the area, an important part of the regeneration process [52]. This could potentially shorten recovery time and improve outcomes for patients who have suffered such injuries.
• Connecting the gut-brain axis:The gut-brain axis is the communication network that connects our digestive tract to the brain. It plays a key role in our overall health and well-being. Interestingly, BPC-157 appears to have a positive effect on this axis. It has been shown to have a range of beneficial effects, from protecting against brain swelling to promoting muscle healing and even improving mood [53]. Its ability to repair damage in both the brain and gut could potentially make it a versatile tool for treating a variety of conditions, including those caused by surgery or certain drugs.
• BPC-157 and leaky gut syndrome: BPC-157 has shown potential in protecting stomach cells from the harmful effects of NSAIDs, a popular group of painkillers. It also helps with "leaky gut syndrome," a condition in which the intestinal lining lets more through than it should and allows harmful substances to enter the bloodstream [54]. Although the exact mechanisms are still under investigation, BPC-157 appears to work by preventing injury to the intestinal lining and reducing its permeability.
• BPC 57 a fistulas and wounds of the gastrointestinal tract: BPC-157 has shown potential in promoting the healing of various types of wounds and injuries, including fistulas, an abnormal connection between two parts of the body, and ulcers in the gastrointestinal tract. It appears to do so by promoting and accelerating the body's natural healing processes [55].
• BPC-157 and gastric ulcers: BPC-157 has shown impressive results in accelerating the healing of gastric ulcers. Both intramuscular (im) and intragastric (ig) administration of BPC-157 reduced the ulcer area and accelerated the healing process in various ulcer models. BPC-157 treatment resulted in fewer lesions compared to untreated groups, with ulcer inhibition rates ranging from 45.7% to 65.6%. Importantly, BPC-157 helped rebuild the stomach lining and produce new tissue in chronic gastric ulcers, which are essential steps in wound healing [56].
• BPC-157 and duodenal ulcers:In another experiment, researchers studied the effects of anti-ulcer drugs on duodenal ulcers (the first part of the small intestine) in rats. Regardless of whether the rats underwent certain surgeries, BPC-157 and other anti-ulcer drugs were effective in preventing duodenal ulcers. However, when the salivary glands were surgically removed, only BPC-157 still showed a protective effect [57]. This means that BPC-157 has a unique protective role, different from other anti-ulcer drugs, and can be effective even after salivary glands are removed.
• BPC-157 and colon injuries:Studies have shown that BPC-157 and other drugs can significantly reduce colon injuries. In rats with colon injuries, BPC-157 continued to protect the colon even after treatment was discontinued, while other drugs did not show this effect [58]. This suggests that BPC-157 may be a promising treatment for colon injuries, even long-term ones.
• BPC-157 and lung and stomach injuries:In another study, researchers found that BPC-157, along with other anti-ulcer agents, was able to significantly reduce lung and stomach injuries in rats. The protective effect of the drugs was better when administered both before and after injury, suggesting a potential role for BPC-157 in the treatment of both lung and gastric injuries [59, 60].
• BPC-157 vs. esophagitis and sphincter dysfunction:Studies on rats with chronic esophagitis and dysfunction of the pylorus and lower esophageal sphincter (the valves that control food entering and exiting the stomach) showed significant improvement after treatment with BPC-157.

The treatment helped relieve inflammation and normalize sphincter function. It is noteworthy that while ranitidine showed no effect, BPC-157 increased pressure in the lower esophageal sphincter and decreased it in the pyloric sphincter, indicating improved function [61, 62]. This suggests the potential of BPC-157 in the treatment of esophagitis and sphincter dysfunction.

• Cytoprotective effects of BPC-157 on gastrointestinal health:A study examining the protective effects of BPC-157 on cells in the gastrointestinal (GI) tract found that BPC-157 was able to reduce GI motility (movement), increase the survival of neurons in the GI tract, promote the growth of GI glial cells (cells that support neurons), and regulate the release of 5-hydroxytryptamine (a molecule involved in signaling in the gut) [63, 64].

Importantly, BPC-157 did not affect the contractile response to 5-HT or norepinephrine, indicating that it has a specific effect on gastrointestinal motility. These findings suggest that BPC-157 may help protect cells in the gastrointestinal tract and could potentially be useful in the treatment of enteric nerve damage and gastrointestinal ulcers [64]. Further studies are needed to understand the exact mechanisms by which BPC-157 exerts these effects.

• Rectovaginal fistulas:A rectovaginal fistula is a serious condition in which an abnormal connection develops between the lower part of the large intestine, the rectum, and the vagina. BPC-157 has shown potential in treating this condition in rats. Rats treated with BPC-157 showed rapid improvement, with healing of both rectal and vaginal defects, increased capacity and no signs of defecation through the fistula. BPC-157 also helped prevent the formation of adhesions and intestinal blockages [65].
• Protecting the stomach and duodenum:In addition to helping treat stomach ulcers, BPC-157 can also protect the stomach and the first part of the small intestine (duodenum) from damage. It also reduces inflammation in these areas. BPC-157 is superior to many standard treatments [66]. These helpful effects may be due to the strong protection that BPC-157 provides to the inner lining of blood vessels.
• Reducing the harmful effects of alcohol on the stomach:When it comes to alcohol-induced stomach damage, BPC-157 has a protective effect. Alcohol consumption can lead to many harmful effects, including stomach damage, high blood pressure, brain swelling, organ damage and more. BPC-157 treatment was able to quickly counteract these harmful effects, reducing cerebral edema, promoting the regeneration of a significant vein, reducing organ damage and stimulating certain cellular pathways [67].
• Colonic-Cutaneous Fistula: A colonic-cutaneous fistula is an abnormal connection between the colon and the skin. In rat studies, BPC-157 was found to have a therapeutic effect on colon-cutaneous fistulas. It accelerated the healing of the colon and skin, eventually leading to fistula closure. The benefits of BPC-157 were found to be independent of nitric oxide production, a biological process associated with healing and immune response [68].

Although these results are based on animal studies and are preliminary, they are encouraging. BPC-157 may offer new ways to support and improve gastrointestinal health.

BPC-157 and hepatoprotective properties

• BPC-157 and alcohol-induced liver damage:In the study, liver damage and portal hypertension (elevated blood pressure in the liver) caused by chronic alcohol consumption were effectively alleviated with BPC-157.Rats were given alcohol for 3 months, which caused liver changes and increased portal blood pressure. The administration of BPC-157 significantly improved the condition of the liver, as evidenced by reduced liver cell size, reduced size of nuclei in these cells and lower hepatic steatosis score. In contrast to ranitidine, BPC-157 has shown promise in preventing and reversing alcohol-induced liver damage [69].
• Budd-Chiari syndrome: BPC-157 has been found to help relieve symptoms associated with Budd-Chiari syndrome, a condition that can block blood vessels running from the liver to the heart. The peptide can reduce symptoms such as irregular heartbeat, which can be a sign of heart failure. What's more, it has created a new pathway for blood flow to bypass blocked areas, reducing pressure in certain veins, the liver and heart, and reducing fluid buildup in the abdominal cavity. It also reduces blood clotting in veins leading to the liver and heart, which may prevent serious liver and lung diseases [70]. It appears that BPC-157 may help maintain a healthy balance of certain biochemicals in the liver during illness. All of this has been tested on rats, not humans.
• Liver fibrosis and portal hypertension:BPC-157 appears to counteract liver damage and improve liver function in rats suffering from biliary ligation, a condition that can cause liver fibrosis and increased blood pressure in the portal vein. BPC-157 normalized liver enzyme levels, reduced jaundice and abdominal fluid accumulation, and improved liver tissue health [71, 72].
• Gastrointestinal and liver damage:BPC-157 has also shown protective effects against gastrointestinal and liver damage. It appears that the way BPC-157 provides this protection may be related to the alpha-adrenergic and central dopaminergic systems - just parts of the body's system that control things like heart rate, vasoconstriction and many other functions [73]. Research suggests that BPC-157 may work by affecting these systems, which could limit the development of lesions.

BPC-157: New hope for the eyes

• BPC-157 and the treatment of glaucoma:Glaucoma is a disease that damages the optic nerve of the eye, often associated with an increase in pressure inside the eye. In a study involving rats, BPC-157 showed potential to normalize eye pressure, an important aspect for people with glaucoma. Whether BPC-157 was administered to rats before or after inducing a glaucoma-like condition, the product immediately normalized eye pressure. It also kept important parts of the eye, such as the optic nerve and retinal blood vessels, healthy [74].
• BPC-157 and corneal damage:BPC-157 has shown impressive potential in healing corneal wounds. The ability of BPC-157 to heal corneal epithelial damage was studied in rats. The peptide showed a significant effect on accelerating the regeneration of corneal injuries. Healing was dose-dependent, and treated groups completely healed from lesions within 40 to 48 hours after injury, demonstrating the potential of BPC-157 in healing corneal defects [75].
• BPC-157 and retinal blood flow problems:Retinal ischemia is a condition in which not enough blood flows to the back of the eye, which can cause serious vision problems. Studies have shown that BPC-157 helped repair damage to the layers of the eye and restored them to normal size. It also got rid of retinal injuries, leading to a rapid restoration of the normal background of the eye and the blood vessels that supply the layers of the eye [76]. These studies suggest that BPC-157 may be an excellent treatment for retinal ischemia.
• BPC-157 a corneal ulceration and transparency:The cornea is the transparent front surface of our eyes. Sometimes it can become injured or ulcerated, which can affect vision. In an experiment, researchers made small incisions on the corneas of rats. They found that BPC-157 significantly accelerated the healing process of these cuts, with complete healing occurring between 72 and 96 hours after injury. Moreover, rats treated with BPC-157 showed the formation of new blood vessels and quickly regained corneal clarity [77]. These findings suggest that BPC-157 may be an effective treatment for corneal injuries and may help maintain corneal clarity.

BPC-157 as an analgesic and anti-inflammatory agent

• BPC-157 and knee pain/arthritis: In a study conducted on knee pain patients, most patients experienced significant relief when treated with BPC-157. The peptide was injected directly into the joint and appeared to help repair injuries, regenerate tissues and reduce the need for knee surgery [78]. These results indicate the potential benefits of BPC-157 in the treatment of various knee or joint conditions, such as arthritis.
• BPC-157 and its analgesic effects: In a study examining the analgesic abilities of BPC-157, rats with surgical incisions were observed for their pain responses. The results showed that BPC-157 could act as a short-term analgesic by increasing pain thresholds at specific times after incision [79]. This suggests the potential of BPC-157 in relieving pain after surgery or trauma, especially in the early phase of pain.
• Arthritis, pain, inflammation and gastric protection: BPC-157 was found to have anti-inflammatory and analgesic (pain relieving) effects. It was tested on rats with chronic inflammatory conditions such as adjuvant arthritis and gastric problems caused by non-steroidal anti-inflammatory drugs. BPC-157 consistently reduced damage to the stomach and small intestine, and reduced the development of arthritis. The compound also showed long-term benefits, with improvement seen after two weeks and benefits persisting after one year [80]. This suggests that BPC-157 can be used for both immediate relief and long-term treatment of these conditions.

Other potential health benefits of BPC-157

• Bladder-vaginal fistula: Bladder-vaginal fistula is a condition in which there is an abnormal passage between the bladder and vagina. BPC-157 was able to reverse the effects of delayed healing in this condition in rats by reducing leakage, promoting tissue growth and healing. The drug improved the body's ability to heal fistulas and prevented the formation of stones that could complicate the condition [81].
• Wound healing and collagen organization: BPC-157 has shown promise in promoting wound healing and early collagen organization. It stimulates the formation of granulation tissue, a key part of wound healing, in both diabetic and non-diabetic models. BPC-157 also stimulated the expression of a gene (egr-1) known to increase the production of certain growth factors and proteins necessary for the formation of a structural component of skin and other tissues (collagen) [82].
• Therapy for cystitis: BPC-157 also shows therapeutic potential in cyclophosphamide-induced cystitis. Cyclophosphamide can cause severe hemorrhagic cystitis, but treatment with BPC-157 significantly reduced these changes, and the wet bladder mass increased. BPC-157 also restored leak point pressure, a measure of bladder function, to normal levels, indicating its potential as a treatment option for cystitis [83].
• Pancreatitis: Pancreatitis is inflammation of the pancreas. BPC-157 has been studied for its potential in treating acute pancreatitis and related syndromes such as vascular insufficiency and multi-organ failure. The results showed that BPC-157 can help improve condition, reduce inflammation and even reverse venous congestion in cases of acute pancreatitis, improving patient outcomes. In addition, it was found that BPC-157 may be effective in treating esophagitis and lower esophageal sphincter insufficiency, two conditions that can occur along with pancreatitis [84].

Summary:

In conclusion, BPC-157, a naturally occurring protein in the stomach, shows great promise in various health-related areas. Based on animal studies, the peptide has shown the potential to aid recovery from various medical conditions, counteract the effects of overdosing on substances such as paracetamol and insulin, mitigate the side effects of chronic ibuprofen use, and even modulate behavioral responses to substances such as amphetamine. While this wide range of benefits is indeed promising, it is important to keep in mind that these findings are still at an early stage and based mainly on animal studies. More research, especially human clinical trials, is needed to confirm these benefits, understand the exact mechanisms and determine the optimal dosage for human use. Therefore, while the future of BPC-157 looks promising, it is important to approach its use with caution and under the guidance of a healthcare professional.

Disclaimer

This article was written for educational purposes and is intended to raise awareness of the substance under discussion. It is important to note that the article is about the substance in general - it is not a description of a specific product (chemical reagent). We do not suggest using chemical reagents on humans - this is prohibited by law. For a product to be used for treatment, it must be registered as a drug. The information in the text is based on available scientific research and is not intended to serve as medical advice or promote self-medication. The reader should consult any health and treatment decisions with a qualified health professional.

Sources:

1. Sikiric P. (1999). The pharmacological properties of the novel peptide BPC-157 (PL-10). Inflammopharmacology, 7(1), 1-14. https://doi.org/10.1007/s10787-999-0022-z https://pubmed.ncbi.nlm.nih.gov/17657443/
2. Sikiric P. (1999). The pharmacological properties of the novel peptide BPC-157 (PL-10). Inflammopharmacology, 7(1), 1-14. https://doi.org/10.1007/s10787-999-0022-z https://pubmed.ncbi.nlm.nih.gov/17657443/
3. https://examine.com/supplements/bpc-157/
4. He, L., Feng, D., Guo, H., Zhou, Y., Li, Z., Zhang, K., Zhang, W., Wang, S., Wang, Z., Hao, Q., Zhang, C., Gao, Y., Gu, J., Zhang, Y., Li, W., & Li, M. (2022). Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs. Frontiers in pharmacology, 13, 1026182. https://doi.org/10.3389/fphar.2022.1026182 https://pubmed.ncbi.nlm.nih.gov/36588717/
5. https://patents.google.com/patent/WO2014142764A1/en
6. https://examine.com/supplements/bpc-157/
7. Perovic, D., Kolenc, D., Bilic, V., Somun, N., Drmic, D., Elabjer, E., Buljat, G., Seiwerth, S., & Sikiric, P. (2019). Stable gastric pentadecapeptide BPC-157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. Journal of orthopaedic surgery and research, 14(1), 199. https://doi.org/10.1186/s13018-019-1242-6 https://pubmed.ncbi.nlm.nih.gov/31266512/
8. Vukojević, J., Vrdoljak, B., Malekinušić, D., Siroglavić, M., Milavić, M., Kolenc, D., Boban Blagaić, A., Batelja, L., Drmić, D., Seiverth, S., & Sikirić, P. (2020). The effect of pentadecapeptide BPC-157 on hippocampal ischemia/reperfusion injuries in rats. Brain and behavior, 10(8), e01726. https://doi.org/10.1002/brb3.1726 https://pubmed.ncbi.nlm.nih.gov/32558293/
9. Perovic, D., Milavic, M., Dokuzovic, S., Krezic, I., Gojkovic, S., Vranes, H., Bebek, I., Bilic, V., Somun, N., Brizic, I., Skorak, I., Hriberski, K., Sikiric, S., Lovric, E., Strbe, S., Kubat, M., Boban Blagaic, A., Skrtic, A., Seiwerth, S., & Sikiric, P. (2022). Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC-157 Therapy. Current issues in molecular biology, 44(5), 1901-1927. https://doi.org/10.3390/cimb44050130 https://pubmed.ncbi.nlm.nih.gov/35678659/
10. Vukojevic, J., Milavić, M., Perović, D., Ilić, S., Čilić, A. Z., Đuran, N., Štrbe, S., Zoričić, Z., Filipčić, I., Brečić, P., Seiverth, S., & Sikirić, P. (2022). Pentadecapeptide BPC-157 and the central nervous system. Neural regeneration research, 17(3), 482-487. https://doi.org/10.4103/1673-5374.320969 https://pubmed.ncbi.nlm.nih.gov/34380875/
11. Gwyer, Daniel; Wragg, Nicholas M.; Wilson, Samantha L. (2019). Gastric pentadecapeptide body protection compound BPC-157 and its role in accelerating musculoskeletal soft tissue healing. Cell and Tissue Research, (), -. doi:10.1007/s00441-019-03016-8 https://sci-hub.mksa.top/10.1007/s00441-019-03016-8
12. Krivic, A., Majerovic, M., Jelic, I., Seiwerth, S., & Sikiric, P. (2008). Modulation of early functional recovery of Achilles tendon to bone unit after transection by BPC-157 and methylprednisolone. Inflammation research: official journal of the European Histamine Research Society ... [et al.], 57(5), 205-210. https://doi.org/10.1007/s00011-007-7056-8 https://pubmed.ncbi.nlm.nih.gov/18594781/
13. Cerovecki, T., Bojanic, I., Brcic, L., Radic, B., Vukoja, I., Seiwerth, S., & Sikiric, P. (2010). Pentadecapeptide BPC-157 (PL 14736) improves ligament healing in the rat. Journal of orthopaedic research: official publication of the Orthopaedic Research Society, 28(9), 1155-1161. https://doi.org/10.1002/jor.21107 https://pubmed.ncbi.nlm.nih.gov/20225319/
14. Staresinic, M., Petrovic, I., Novinscak, T., Jukic, I., Pevec, D., Suknaic, S., Kokic, N., Batelja, L., Brcic, L., Boban-Blagaic, A., Zoric, Z., Ivanovic, D., Ajduk, M., Sebecic, B., Patrlj, L., Sosa, T., Buljat, G., Anic, T., Seiwerth, S., & Sikiric, P. (2006). Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC-157. Journal of orthopaedic research: official publication of the Orthopaedic Research Society, 24(5), 1109-1117. https://doi.org/10.1002/jor.20089 https://pubmed.ncbi.nlm.nih.gov/16609979/
15. Pevec, D., Novinscak, T., Brcic, L., Sipos, K., Jukic, I., Staresinic, M., Mise, S., Brcic, I., Kolenc, D., Klicek, R., Banic, T., Sever, M., Kocijan, A., Berkopic, L., Radic, B., Buljat, G., Anic, T., Zoricic, I., Bojanic, I., Seiwerth, S., ... Sikiric, P. (2010). Impact of pentadecapeptide BPC-157 on muscle healing impaired by systemic corticosteroid application. Medical science monitor: international medical journal of experimental and clinical research, 16(3), BR81-BR88. https://pubmed.ncbi.nlm.nih.gov/20190676/
16. Japjec, M., Horvat Pavlov, K., Petrovic, A., Staresinic, M., Sebecic, B., Buljan, M., Vranes, H., Giljanovic, A., Drmic, D., Japjec, M., Prtoric, A., Lovric, E., Batelja Vuletic, L., Dobric, I., Boban Blagaic, A., Skrtic, A., Seiwerth, S., & Predrag, S. (2021). Stable Gastric Pentadecapeptide BPC-157 as a Therapy for the Disable Myotendinous Junctions in Rats. Biomedicines, 9(11), 1547. https://doi.org/10.3390/biomedicines9111547 https://pubmed.ncbi.nlm.nih.gov/34829776/
17. Chang, C. H., Tsai, W. C., Hsu, Y. H., & Pang, J. H. (2014). Pentadecapeptide BPC-157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules (Basel, Switzerland), 19(11), 19066-19077.https://doi.org/10.3390/molecules191119066 https://pubmed.ncbi.nlm.nih.gov/25415472/
18. Tudor, M., Jandric, I., Marovic, A., Gjurasin, M., Perovic, D., Radic, B., Blagaic, A. B., Kolenc, D., Brcic, L., Zarkovic, K., Seiwerth, S., & Sikiric, P. (2010). Traumatic brain injury in mice and pentadecapeptide BPC-157 effect. Regulatory peptides, 160(1-3), 26-32. https://doi.org/10.1016/j.regpep.2009.11.012 https://pubmed.ncbi.nlm.nih.gov/19931318/
19. Gojkovic, S., Krezic, I., Vranes, H., Zizek, H., Drmic, D., Horvat Pavlov, K., Petrovic, A., Batelja Vuletic, L., Milavic, M., Sikiric, S., Stilinovic, I., Samara, M., Knezevic, M., Barisic, I., Sjekavica, I., Lovric, E., Skrtic, A., Seiwerth, S., & Sikiric, P. (2021). BPC-157 Therapy and the Permanent Occlusion of the Superior Sagittal Sinus in Rat: Vascular Recruitment. Biomedicines, 9(7), 744. https://doi.org/10.3390/biomedicines9070744 https://pubmed.ncbi.nlm.nih.gov/34203464/
20. Ilic, S., Drmic, D., Zarkovic, K., Kolenc, D., Coric, M., Brcic, L., Klicek, R., Radic, B., Sever, M., Djuzel, V., Ivica, M., Boban Blagaic, A., Zoricic, Z., Anic, T., Zoricic, I., Djidic, S., Romic, Z., Seiwerth, S., & Sikiric, P. (2010). High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC-157 (PL 14736). Journal of physiology and pharmacology: an official journal of the Polish Physiological Society, 61(2), 241-250. https://pubmed.ncbi.nlm.nih.gov/20436226/
21. Ilic, S., Brcic, I., Mester, M., Filipovic, M., Sever, M., Klicek, R., Barisic, I., Radic, B., Zoricic, Z., Bilic, V., Berkopic, L., Brcic, L., Kolenc, D., Romic, Z., Pazanin, L., Seiwerth, S., & Sikiric, P. (2009). Over-dose insulin and stable gastric pentadecapeptide BPC-157. Attenuated gastric ulcers, seizures, brain lesions, hepatomegaly, fatty liver, breakdown of liver glycogen, profound hypoglycemia and calcification in rats. Journal of physiology and pharmacology: an official journal of the Polish Physiological Society, 60 Suppl 7, 107-114. https://pubmed.ncbi.nlm.nih.gov/20388953/
22. Drmic, D., Kolenc, D., Ilic, S., Bauk, L., Sever, M., Zenko Sever, A., Luetic, K., Suran, J., Seiwerth, S., & Sikiric, P. (2017). Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC-157 or L-arginine, aggravation by L-NAME. World journal of gastroenterology, 23(29), 5304-5312. https://doi.org/10.3748/wjg.v23.i29.5304 https://pubmed.ncbi.nlm.nih.gov/28839430/
23. Sikiric, P., Udovicic, M., Barisic, I., Balenovic, D., Zivanovic Posilovic, G., Strinic, D., Uzun, S., Sikiric, S., Krezic, I., Zizek, H., Yago, H., Gojkovic, S., Smoday, I. M., Kalogjera, L., Vranes, H., Sola, M., Strbe, S., Koprivanac, A., Premuzic Mestrovic, I., Mestrovic, T., ... Seiwerth, S. (2022). Stable Gastric Pentadecapeptide BPC-157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation. Biomedicines, 10(11), 2696. https://doi.org/10.3390/biomedicines10112696 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687817/
24. Barisic, I., Balenovic, D., Udovicic, M., Bardak, D., Strinic, D., Vlainić, J., Vranes, H., Smoday, I. M., Krezic, I., Milavic, M., Sikiric, S., Uzun, S., Zivanovic Posilovic, G., Strbe, S., Vukoja, I., Lovric, E., Lozic, M., Sever, M., Lovric Bencic, M., Boban Blagaic, A., ... Sikiric, P. (2022). Stable Gastric Pentadecapeptide BPC-157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats. Biomedicines, 10(2), 265. https://doi.org/10.3390/biomedicines10020265 https://pubmed.ncbi.nlm.nih.gov/35203478/
25. Knezevic, M., Gojkovic, S., Krezic, I., Zizek, H., Malekinusic, D., Vrdoljak, B., Knezevic, T., Vranes, H., Drmic, D., Staroveski, M., Djuzel, A., Rajkovic, Z., Kolak, T., Lovric, E., Milavic, M., Sikiric, S., Tvrdeic, A., Patrlj, L., Strbe, S., Sola, M., ... Sikiric, P. (2021). Occluded Superior Mesenteric Artery and Vein. Therapy with the Stable Gastric Pentadecapeptide BPC-157. Biomedicines, 9(7), 792. https://doi.org/10.3390/biomedicines9070792 https://pubmed.ncbi.nlm.nih.gov/34356860/
26. Udovicic, M., Sever, M., Kavur, L., Loncaric, K., Barisic, I., Balenovic, D., Zivanovic Posilovic, G., Strinic, D., Uzun, S., Batelja Vuletic, L., Sikiric, S., Skrtic, A., Drmic, D., Boban Blagaic, A., Lovric Bencic, M., Seiwerth, S., & Sikiric, P. (2021). Stable Gastric Pentadecapeptide BPC-157 Therapy for Monocrotaline-Induced Pulmonary Hypertension in Rats Leads to Prevention and Reversal. Biomedicines, 9(7), 822. https://doi.org/10.3390/biomedicines9070822 https://pubmed.ncbi.nlm.nih.gov/34356886/
27. Knezevic, M., Gojkovic, S., Krezic, I., Zizek, H., Malekinusic, D., Vrdoljak, B., Vranes, H., Knezevic, T., Barisic, I., Horvat Pavlov, K., Drmic, D., Staroveski, M., Djuzel, A., Rajkovic, Z., Kolak, T., Kocman, I., Lovric, E., Milavic, M., Sikiric, S., Tvrdeic, A., ... Sikiric, P. (2021). Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC-157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortic Hypotension. Biomedicines, 9(6), 609. https://doi.org/10.3390/biomedicines9060609 https://pubmed.ncbi.nlm.nih.gov/34073625/
28. Balenovic, D., Bencic, M. L., Udovicic, M., Simonji, K., Hanzevacki, J. S., Barisic, I., Kranjcevic, S., Prkacin, I., Coric, V., Brcic, L., Coric, M., Brcic, I., Borovic, S., Radic, B., Drmic, D., Vrcic, H., Seiwerth, S., & Sikiric, P. (2009). Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC-157: a relation with NO-system. Regulatory peptides, 156(1-3), 83-89. https://doi.org/10.1016/j.regpep.2009.05.008 https://pubmed.ncbi.nlm.nih.gov/19465062/
29. Stupnisek, M., Kokot, A., Drmic, D., Hrelec Patrlj, M., Zenko Sever, A., Kolenc, D., Radic, B., Suran, J., Bojic, D., Vcev, A., Seiwerth, S., & Sikiric, P. (2015). Pentadecapeptide BPC-157 Reduces Bleeding and Thrombocytopenia after Amputation in Rats Treated with Heparin, Warfarin, L-NAME and L-Arginine. PloS one, 10(4), e0123454. https://doi.org/10.1371/journal.pone.0123454 https://pubmed.ncbi.nlm.nih.gov/25897838/
30. Tepes, M., Gojkovic, S., Krezic, I., Zizek, H., Vranes, H., Madzar, Z., Santak, G., Batelja, L., Milavic, M., Sikiric, S., Kocman, I., Simonji, K., Samara, M., Knezevic, M., Barisic, I., Lovric, E., Strbe, S., Kokot, A., Sjekavica, I., Kolak, T., ... Sikiric, P. (2021). Stable Gastric Pentadecapeptide BPC-157 Therapy for Primary Abdominal Compartment Syndrome in Rats. Frontiers in pharmacology, 12, 718147. https://doi.org/10.3389/fphar.2021.718147 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710746/
31. Knezevic, M., Gojkovic, S., Krezic, I., Zizek, H., Malekinusic, D., Vrdoljak, B., Vranes, H., Knezevic, T., Barisic, I., Horvat Pavlov, K., Drmic, D., Staroveski, M., Djuzel, A., Rajkovic, Z., Kolak, T., Kocman, I., Lovric, E., Milavic, M., Sikiric, S., Tvrdeic, A., ... Sikiric, P. (2021). Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC-157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortic Hypotension. Biomedicines, 9(6), 609. https://doi.org/10.3390/biomedicines9060609 https://pubmed.ncbi.nlm.nih.gov/34073625/
32. Sikiric, P., Separovic, J., Buljat, G., Anic, T., Stancic-Rokotov, D., Mikus, D., Marovic, A., Prkacin, I., Duplancic, B., Zoricic, I., Aralica, G., Lovric-Bencic, M., Ziger, T., Perovic, D., Rotkvic, I., Mise, S., Hanzevacki, M., Hahn, V., Seiwerth, S., Turkovic, B., ... Rucman, R. (2000). The antidepressant effect of an antiulcer pentadecapeptide BPC-157 in Porsolt's test and chronic unpredictable stress in rats. A comparison with antidepressants. Journal of physiology, Paris, 94(2), 99-104. https://doi.org/10.1016/s0928-4257(00)00148-0 https://pubmed.ncbi.nlm.nih.gov/10791689/
33. Boban Blagaic, A., Blagaic, V., Mirt, M., Jelovac, N., Dodig, G., Rucman, R., Petek, M., Turkovic, B., Anic, T., Dubovecak, M., Staresinic, M., Seiwerth, S., & Sikiric, P. (2005). Gastric pentadecapeptide BPC-157 effective against serotonin syndrome in rats. European journal of pharmacology, 512(2-3), 173-179. https://doi.org/10.1016/j.ejphar.2005.02.033 https://pubmed.ncbi.nlm.nih.gov/15840402/
34. Sikiric, P., Jelovac, N., Jelovac-Gjeldum, A., Dodig, G., Staresinic, M., Anic, T., Zoricic, I., Ferovic, D., Aralica, G., Buljat, G., Prkacin, I., Lovric-Bencic, M., Separovic, J., Seiwerth, S., Rucman, R., Petek, M., Turkovic, B., & Ziger, T. (2001). Anxiolytic effect of BPC-157, a gastric pentadecapeptide: shock probe/burying test and light/dark test. Acta pharmacologica Sinica, 22(3), 225-230. https://pubmed.ncbi.nlm.nih.gov/11742568/
35. Tohyama, Y., Sikirić, P., & Diksic, M. (2004). Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: alpha-methyl-L-tryptophan autoradiographic measurements. Life sciences, 76(3), 345-357. https://doi.org/10.1016/j.lfs.2004.08.010 https://pubmed.ncbi.nlm.nih.gov/15531385/
36. Balenovic, D., Bencic, M. L., Udovicic, M., Simonji, K., Hanzevacki, J. S., Barisic, I., Kranjcevic, S., Prkacin, I., Coric, V., Brcic, L., Coric, M., Brcic, I., Borovic, S., Radic, B., Drmic, D., Vrcic, H., Seiwerth, S., & Sikiric, P. (2009). Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC-157: a relation with NO-system. Regulatory peptides, 156(1-3), 83-89. https://doi.org/10.1016/j.regpep.2009.05.008 https://pubmed.ncbi.nlm.nih.gov/19465062/
37. Stambolija, V., Stambolija, T. P., Holjevac, J. K., Murselovic, T., Radonic, J., Duzel, V., Duplancic, B., Uzun, S., Zivanovic-Posilovic, G., Kolenc, D., Drmic, D., Romic, Z., Seiwerth, S., & Sikiric, P. (2016). BPC-157: The counteraction of succinylcholine, hyperkalemia, and arrhythmias. European journal of pharmacology, 781, 83-91. https://doi.org/10.1016/j.ejphar.2016.04.004 https://pubmed.ncbi.nlm.nih.gov/27060013/
38. Strinic, D., Belosic Halle, Z., Luetic, K., Nedic, A., Petrovic, I., Sucic, M., Zivanovic Posilovic, G., Balenovic, D., Strbe, S., Udovicic, M., Drmic, D., Stupnisek, M., Lovric Bencic, M., Seiwerth, S., & Sikiric, P. (2017). BPC-157 counteracts QTc prolongation induced by haloperidol, fluphenazine, clozapine, olanzapine, quetiapine, sulpiride, and metoclopramide in rats. Life sciences, 186, 66-79. https://doi.org/10.1016/j.lfs.2017.08.006 https://pubmed.ncbi.nlm.nih.gov/28797793/
39. Huang, B. S., Huang, S. C., Chen, F. H., Chang, Y., Mei, H. F., Huang, H. Y., Chen, W. Y., & Pang, J. S. (2022). Pentadecapeptide BPC-157 efficiently reduces radiation-induced liver injury and lipid accumulation through Kruppel-like factor 4 upregulation both in vivo and in vitro. Life sciences, 310, 121072. https://doi.org/10.1016/j.lfs.2022.121072 https://pubmed.ncbi.nlm.nih.gov/36228773/
40. 26. ilic S., Drmic D., Franjic S., Kolenc D., Coric M., Brcic L., Klicek R., Radic B., Sever M., Djuzel V., Filipovic M., Djakovic Z., Stambolija V., Blagaic A.B., Zoricic I., Gjurasin M., Stupnisek M., Romic Z., Zarkovic K., Dzidic S., Seiwerth S., Sikiric P. Pentadecapeptide BPC-157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions. Life Sci. 2011;88(11-12):535–542. [http://dx.doi.org/10.1016/j.lfs.2011.01.015]. [PMID: 21295044]. [PubMed] [Google Scholar]
41. Strbe, S., Gojkovic, S., Krezic, I., Zizek, H., Vranes, H., Barisic, I., Strinic, D., Orct, T., Vukojevic, J., Ilic, S., Lovric, E., Muzinic, D., Kolenc, D., Filipčić, I., Zoricic, Z., Marcinko, D., Boban Blagaic, A., Skrtic, A., Seiwerth, S., & Sikiric, P. (2021). Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC-157. Biomedicines, 9(11), 1506. https://doi.org/10.3390/biomedicines9111506 https://pubmed.ncbi.nlm.nih.gov/34829735/
42. Prkacin, I., Separovic, J., Aralicia, G., Perovic, D., Gjurasin, M., Lovric-Bencic, M., Stancic-Rokotov, D., Staresinic, M., Anic, T., Mikus, D., Sikiric, P., Seiwerth, S., Mise, S., Rotkvic, I., Jagic, V., Rucman, R., Petek, M., Turkovic, B., Marovic, A., Sebecic, B., ... Kokic, N. (2001). Portal hypertension and liver lesions in chronically alcoholic drinking rats prevented and reversed by stable gastric pentadecapeptide BPC-157 (PL-10, PLD-116), and propranolol, but not ranitidine. Journal of physiology, Paris, 95(1-6), 315-324. https://doi.org/10.1016/s0928-4257(01)00044-4 https://pubmed.ncbi.nlm.nih.gov/11595456/
43. Zivanovic-Posilovic, G., Balenovic, D., Barisic, I., Strinic, D., Stambolija, V., Udovicic, M., Uzun, S., Drmic, D., Vlainic, J., Bencic, M. L., Sindic, A., Seiwerth, S., & Sikiric, P. (2016). Stable gastric pentadecapeptide BPC-157 and bupivacaine. European journal of pharmacology, 793, 56-65. https://doi.org/10.1016/j.ejphar.2016.10.035 https://pubmed.ncbi.nlm.nih.gov/27815173/
44. Medvidovic-Grubisic, M., Stambolija, V., Kolenc, D., Katancic, J., Murselovic, T., Plestina-Borjan, I., Strbe, S., Drmic, D., Barisic, I., Sindic, A., Seiwerth, S., & Sikiric, P. (2017). Hypermagnesemia disturbances in rats, NO-related: pentadecapeptide BPC-157 abrogates, L-NAME and L-arginine worsens. Inflammopharmacology, 25(4), 439-449. https://doi.org/10.1007/s10787-017-0323-6 https://pubmed.ncbi.nlm.nih.gov/28210905/
45. 27 Ilic S., Drmic D., Zarkovic K., Kolenc D., Coric M., Brcic L., Klicek R., Radic B., Sever M., Djuzel V., Ivica M., Boban Blagaic A., Zoricic Z., Anic T., Zoricic I., Djidic S., Romic Z., Seiwerth S., Sikiric P. High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC-157 (PL 14736). J. Physiol. Pharmacol. 2010;61(2):241-250 [PMID: 20436226]. [PubMed] [Google Scholar]
46. Ilic, S., Drmic, D., Franjic, S., Kolenc, D., Coric, M., Brcic, L., Klicek, R., Radic, B., Sever, M., Djuzel, V., Filipovic, M., Djakovic, Z., Stambolija, V., Blagaic, A. B., Zoricic, I., Gjurasin, M., Stupnisek, M., Romic, Z., Zarkovic, K., Dzidic, S., ... Sikiric, P. (2011). Pentadecapeptide BPC-157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions. Life sciences, 88(11-12), 535-542. https://doi.org/10.1016/j.lfs.2011.01.015 https://pubmed.ncbi.nlm.nih.gov/21295044/
47. Ilic, S., Brcic, I., Mester, M., Filipovic, M., Sever, M., Klicek, R., Barisic, I., Radic, B., Zoricic, Z., Bilic, V., Berkopic, L., Brcic, L., Kolenc, D., Romic, Z., Pazanin, L., Seiwerth, S., & Sikiric, P. (2009). Over-dose insulin and stable gastric pentadecapeptide BPC-157. Attenuated gastric ulcers, seizures, brain lesions, hepatomegaly, fatty liver, breakdown of liver glycogen, profound hypoglycemia and calcification in rats. Journal of physiology and pharmacology: an official journal of the Polish Physiological Society, 60 Suppl 7, 107-114. https://pubmed.ncbi.nlm.nih.gov/20388953/
48. Ilic, S., Drmic, D., Zarkovic, K., Kolenc, D., Brcic, L., Radic, B., Djuzel, V., Blagaic, A. B., Romic, Z., Dzidic, S., Kalogjera, L., Seiwerth, S., & Sikiric, P. (2011). Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC-157 in rats. European journal of pharmacology, 667(1-3), 322-329. https://doi.org/10.1016/j.ejphar.2011.05.038 https://pubmed.ncbi.nlm.nih.gov/21645505/
49. Sikiric, P., Jelovac, N., Jelovac-Gjeldum, A., Dodig, G., Staresinic, M., Anic, T., Zoricic, I., Rak, D., Perovic, D., Aralica, G., Buljat, G., Prkacin, I., Lovric-Bencic, M., Separovic, J., Seiwerth, S., Rucman, R., Petek, M., Turkovic, B., Ziger, T., Boban-Blagaic, A., ... Babic, S. (2002). Pentadecapeptide BPC-157 attenuates chronic amphetamine-induced behavior disturbances. Acta pharmacologica Sinica, 23(5), 412-422. https://pubmed.ncbi.nlm.nih.gov/11978191/
50. Klicek, R., Kolenc, D., Suran, J., Drmic, D., Brcic, L., Aralica, G., Sever, M., Holjevac, J., Radic, B., Turudic, T., Kokot, A., Patrlj, L., Rucman, R., Seiwerth, S., & Sikiric, P. (2013). Stable gastric pentadecapeptide BPC-157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability. Journal of physiology and pharmacology: an official journal of the Polish Physiological Society, 64(5), 597-612. https://pubmed.ncbi.nlm.nih.gov/24304574/
51. Sever, M., Klicek, R., Radic, B., Brcic, L., Zoricic, I., Drmic, D., Ivica, M., Barisic, I., Ilic, S., Berkopic, L., Blagaic, A. B., Coric, M., Kolenc, D., Vrcic, H., Anic, T., Seiwerth, S., & Sikiric, P. (2009). Gastric pentadecapeptide BPC-157 and short bowel syndrome in rats. Digestive diseases and sciences, 54(10), 2070-2083. https://doi.org/10.1007/s10620-008-0598-y https://pubmed.ncbi.nlm.nih.gov/19093208/
52. Drmic, D., Samara, M., Vidovic, T., Malekinusic, D., Antunovic, M., Vrdoljak, B., Ruzman, J., Milkovic Perisa, M., Horvat Pavlov, K., Jeyakumar, J., Seiwerth, S., & Sikiric, P. (2018). Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC-157, L-NAME and L-arginine. World journal of gastroenterology, 24(48), 5462-5476. https://doi.org/10.3748/wjg.v24.i48.5462 https://pubmed.ncbi.nlm.nih.gov/30622376/
53. Sikiric, P., Gojkovic, S., Krezic, I., Smoday, I. M., Kalogjera, L., Zizek, H., Oroz, K., Vranes, H., Vukovic, V., Labidi, M., Strbe, S., Baketic Oreskovic, L., Sever, M., Tepes, M., Knezevic, M., Barisic, I., Blagaic, V., Vlainic, J., Dobric, I., Staresinic, M., ... Seiwerth, S. (2023). Stable Gastric Pentadecapeptide BPC-157 May Recover Brain-Gut Axis and Gut-Brain Axis Function. Pharmaceuticals (Basel, Switzerland), 16(5), 676. https://doi.org/10.3390/ph16050676 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224484/
54. Park, J. M., Lee, H. J., Sikiric, P., & Hahm, K. B. (2020). BPC-157 Rescued NSAID-cytotoxicity Via Stabilizing Intestinal Permeability and Enhancing Cytoprotection. Current pharmaceutical design, 26(25), 2971-2981. https://doi.org/10.2174/1381612826666200523180301 https://pubmed.ncbi.nlm.nih.gov/32445447/
55. Sikiric, P., Drmic, D., Sever, M., Klicek, R., Blagaic, A. B., Tvrdeic, A., Kralj, T., Kovac, K. K., Vukojevic, J., Siroglavic, M., Gojkovic, S., Krezic, I., Pavlov, K. H., Rasic, D., Mirkovic, I., Kokot, A., Skrtic, A., & Seiwerth, S. (2020). Fistulas Healing. Stable Gastric Pentadecapeptide BPC-157 Therapy. Current pharmaceutical design, 26(25), 2991-3000. https://doi.org/10.2174/1381612826666200424180139 https://pubmed.ncbi.nlm.nih.gov/32329684/
56. Xue, X. C., Wu, Y. J., Gao, M. T., Li, W. G., Zhao, N., Wang, Z. L., Bao, C. J., Yan, Z., & Zhang, Y. Q. (2004). Protective effects of pentadecapeptide BPC-157 on gastric ulcer in rats. World journal of gastroenterology, 10(7), 1032-1036. https://doi.org/10.3748/wjg.v10.i7.1032 https://pubmed.ncbi.nlm.nih.gov/15052688/
57. Sikiric, P., Seiwerth, S., Grabarevic, Z., Petek, M., Rucman, R., Turkovic, B., Rotkvic, I., Jagic, V., Duvnjak, M., & Mise, S. (1994). The beneficial effect of BPC-157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promoters and gut peptides. Life sciences, 54(5), PL63-PL68. https://doi.org/10.1016/0024-3205(94)00796-9 https://pubmed.ncbi.nlm.nih.gov/7904712/
58. Sikiric, P., Seiwerth, S., Aralica, G., Perovic, D., Staresinic, M., Anic, T., Gjurasin, M., Prkacin, I., Separovic, J., Stancic-Rokotov, D., Lovric-Bencic, M., Mikus, D., Turkovic, B., Rotkvic, I., Mise, S., Rucman, R., Petek, M., Ziger, T., Sebecic, B., Ivasovic, Z., ... Sjekavica, I. (2001). Therapy effect of antiulcer agents on new chronic cysteamine colon lesion in rat. Journal of physiology, Paris, 95(1-6), 283-288. https://doi.org/10.1016/s0928-4257(01)00039-0 https://pubmed.ncbi.nlm.nih.gov/11595451/
59. Stancic-Rokotov, D., Sikiric, P., Seiwerth, S., Slobodnjak, Z., Aralica, J., Aralica, G., Perovic, D., Anic, T., Zoricic, I., Buljat, G., Prkacin, I., Gjurasin, M., Rucman, R., Petek, M., Turkovic, B., Ivasovic, Z., Jagic, V., Staresinic, M., & Boban-Blagaic, A. (2001). Ethanol gastric lesion aggravated by lung injury in rat. Therapy effect of antiulcer agents. Journal of physiology, Paris, 95(1-6), 289-293. https://doi.org/10.1016/s0928-4257(01)00040-7 https://pubmed.ncbi.nlm.nih.gov/11595452/
60. Stancic-Rokotov, D., Slobodnjak, Z., Aralica, J., Aralica, G., Perovic, D., Staresinic, M., Gjurasin, M., Anic, T., Zoricic, I., Buljat, G., Prkacin, I., Sikiric, P., Seiwerth, S., Rucman, R., Petek, M., Turkovic, B., Kokic, N., Jagic, V., & Boban-Blagaic, A. (2001). Lung lesions and anti-ulcer agents beneficial effect: anti-ulcer agents pentadecapeptide BPC-157, ranitidine, omeprazole and atropine ameliorate lung lesion in rats. Journal of physiology, Paris, 95(1-6), 303-308. https://doi.org/10.1016/s0928-4257(01)00042-0 https://pubmed.ncbi.nlm.nih.gov/11595454/
61. Petrovic, I., Dobric, I., Drmic, D., Sever, M., Klicek, R., Radic, B., Brcic, L., Kolenc, D., Zlatar, M., Kunjko, K., Jurcic, D., Martinac, M., Rasic, Z., Boban Blagaic, A., Romic, Z., Seiwerth, S., & Sikiric, P. (2011). BPC-157 therapy to detriment sphincters failure-esophagitis-pancreatitis in rat and acute pancreatitis patients low sphincters pressure. Journal of physiology and pharmacology: an official journal of the Polish Physiological Society, 62(5), 527-534. https://pubmed.ncbi.nlm.nih.gov/22204800/
62. Dobric, I., Drvis, P., Petrovic, I., Shejbal, D., Brcic, L., Blagaic, A. B., Batelja, L., Sever, M., Kokic, N., Tonkic, A., Zoricic, I., Mise, S., Staresinic, M., Radic, B., Jakir, A., Babel, J., Ilic, S., Vuksic, T., Jelic, I., Anic, T., ... Sikiric, P. (2007). Prolonged esophagitis after primary dysfunction of the pyloric sphincter in the rat and therapeutic potential of the gastric pentadecapeptide BPC-157. Journal of pharmacological sciences, 104(1), 7-18. https://doi.org/10.1254/jphs.fp0061322 https://pubmed.ncbi.nlm.nih.gov/17452811/
63. Gojkovic, S., Krezic, I., Vranes, H., Zizek, H., Drmic, D., Batelja Vuletic, L., Milavic, M., Sikiric, S., Stilinovic, I., Simeon, P., Knezevic, M., Kolak, T., Tepes, M., Simonji, K., Strbe, S., Nikolac Gabaj, N., Barisic, I., Oreskovic, E. G., Lovric, E., Kokot, A., ... Sikiric, P. (2021). Robert's Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC-157. Biomedicines, 9(10), 1300. https://doi.org/10.3390/biomedicines9101300 https://pubmed.ncbi.nlm.nih.gov/34680419/
64. Wang, X. Y., Qu, M., Duan, R., Shi, D., Jin, L., Gao, J., Wood, J. D., Li, J., & Wang, G. D. (2019). Cytoprotective Mechanism of the Novel Gastric Peptide BPC157 in Gastrointestinal Tract and Cultured Enteric Neurons and Glial Cells. Neuroscience bulletin, 35(1), 167-170. https://doi.org/10.1007/s12264-018-0269-8 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357276/
65. Baric, M., Sever, A. Z., Vuletic, L. B., Rasic, Z., Sever, M., Drmic, D., Pavelic-Turudic, T., Sucic, M., Vrcic, H., Seiwerth, S., & Sikiric, P. (2016). Stable gastric pentadecapeptide BPC-157 heals rectovaginal fistula in rats. Life sciences, 148, 63-70. https://doi.org/10.1016/j.lfs.2016.02.029 https://pubmed.ncbi.nlm.nih.gov/26872976/
66. Bedekovic, V., Mise, S., Anic, T., Staresinic, M., Gjurasin, M., Kopljar, M., Kalogjera, L., Drvis, P., Boban Blagaic, A., Batelja, L., Seiwerth, S., & Sikiric, P. (2003). Different effect of antiulcer agents on rat cysteamine-induced duodenal ulcer after sialoadenectomy, but not gastrectomy. European journal of pharmacology, 477(1), 73-80. https://doi.org/10.1016/j.ejphar.2003.08.013 https://pubmed.ncbi.nlm.nih.gov/14512101/
67. Prkacin, I., Separovic, J., Aralicia, G., Perovic, D., Gjurasin, M., Lovric-Bencic, M., Stancic-Rokotov, D., Staresinic, M., Anic, T., Mikus, D., Sikiric, P., Seiwerth, S., Mise, S., Rotkvic, I., Jagic, V., Rucman, R., Petek, M., Turkovic, B., Marovic, A., Sebecic, B., ... Kokic, N. (2001). Portal hypertension and liver lesions in chronically alcoholic drinking rats prevented and reversed by stable gastric pentadecapeptide BPC-157 (PL-10, PLD-116), and propranolol, but not ranitidine. Journal of physiology, Paris, 95(1-6), 315-324. https://doi.org/10.1016/s0928-4257(01)00044-4 https://pubmed.ncbi.nlm.nih.gov/11595456/
68. Klicek, R., Sever, M., Radic, B., Drmic, D., Kocman, I., Zoricic, I., Vuksic, T., Ivica, M., Barisic, I., Ilic, S., Berkopic, L., Vrcic, H., Brcic, L., Blagaic, A. B., Coric, M., Brcic, I., Rokotov, D. S., Anic, T., Seiwerth, S., & Sikiric, P. (2008). Pentadecapeptide BPC-157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: role of the nitric oxide-system. Journal of pharmacological sciences, 108(1), 7-17. https://doi.org/10.1254/jphs.fp0072161 https://pubmed.ncbi.nlm.nih.gov/18818478/
69. Prkacin, I., Separovic, J., Aralicia, G., Perovic, D., Gjurasin, M., Lovric-Bencic, M., Stancic-Rokotov, D., Staresinic, M., Anic, T., Mikus, D., Sikiric, P., Seiwerth, S., Mise, S., Rotkvic, I., Jagic, V., Rucman, R., Petek, M., Turkovic, B., Marovic, A., Sebecic, B., ... Kokic, N. (2001). Portal hypertension and liver lesions in chronically alcoholic drinking rats prevented and reversed by stable gastric pentadecapeptide BPC-157 (PL-10, PLD-116), and propranolol, but not ranitidine. Journal of physiology, Paris, 95(1-6), 315-324. https://doi.org/10.1016/s0928-4257(01)00044-4 https://pubmed.ncbi.nlm.nih.gov/11595456/
70. Gojkovic, S., Krezic, I., Vrdoljak, B., Malekinusic, D., Barisic, I., Petrovic, A., Horvat Pavlov, K., Kolovrat, M., Duzel, A., Knezevic, M., Kasnik Kovac, K., Drmic, D., Batelja Vuletic, L., Kokot, A., Boban Blagaic, A., Seiwerth, S., & Sikiric, P. (2020). Pentadecapeptide BPC-157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats. World journal of gastrointestinal pathophysiology, 11(1), 1-19. https://doi.org/10.4291/wjgp.v11.i1.1 https://pubmed.ncbi.nlm.nih.gov/32226643/
71. Kolovrat, M., Gojkovic, S., Krezic, I., Malekinusic, D., Vrdoljak, B., Kasnik Kovac, K., Kralj, T., Drmic, D., Barisic, I., Horvat Pavlov, K., Petrovic, A., Duzel, A., Knezevic, M., Mirkovic, I., Kokot, A., Boban Blagaic, A., Seiwerth, S., & Sikiric, P. (2020). Pentadecapeptide BPC-157 resolves Pringle maneuver in rats, both ischemia and reperfusion. World journal of hepatology, 12(5), 184-206. https://doi.org/10.4254/wjh.v12.i5.184 https://pubmed.ncbi.nlm.nih.gov/32547687/
72. Sever, A. Z., Sever, M., Vidovic, T., Lojo, N., Kolenc, D., Vuletic, L. B., Drmic, D., Kokot, A., Zoricic, I., Coric, M., Vlainic, J., Poljak, L., Seiwerth, S., & Sikiric, P. (2019). Stable gastric pentadecapeptide BPC-157 in the therapy of the rats with bile duct ligation. European journal of pharmacology, 847, 130-142. https://doi.org/10.1016/j.ejphar.2019.01.030 https://pubmed.ncbi.nlm.nih.gov/30690000/
73. Sikirić, P., Mazul, B., Seiwerth, S., Grabarević, Z., Rucman, R., Petek, M., Jagić, V., Turković, B., Rotkvić, I., Mise, S., Zoricić, I., Jurina, L., Konjevoda, P., Hanzevacki, M., Gjurasin, M., Separović, J., Ljubanović, D., Artuković, B., Bratulić, M., Tisljar, M., ... Sumajstorcić, J. (1997). Pentadecapeptide BPC-157 interactions with adrenergic and dopaminergic systems in mucosal protection in stress. Digestive diseases and sciences, 42(3), 661-671. https://doi.org/10.1023/a:1018880000644 https://pubmed.ncbi.nlm.nih.gov/9073154/
74. Kralj, T., Kokot, A., Zlatar, M., Masnec, S., Kasnik Kovac, K., Milkovic Perisa, M., Batelja Vuletic, L., Giljanovic, A., Strbe, S., Sikiric, S., Balog, S., Sontacchi, B., Sontacchi, D., Buljan, M., Lovric, E., Boban Blagaic, A., Skrtic, A., Seiwerth, S., & Sikiric, P. (2021). Stable Gastric Pentadecapeptide BPC-157 Therapy of Rat Glaucoma. Biomedicines, 10(1), 89. https://doi.org/10.3390/biomedicines10010089 https://pubmed.ncbi.nlm.nih.gov/35052769/
75. Lazić, R., Gabrić, N., Dekaris, I., Bosnar, D., Boban-Blagaić, A., & Sikirić, P. (2005). Gastric pentadecapeptide BPC-157 promotes corneal epithelial defect healing in rats. Collegium anthropologicum, 29(1), 321-325. https://pubmed.ncbi.nlm.nih.gov/16117343/
76. Zlatar, M., Kokot, A., Vuletic, L. B., Masnec, S., Kralj, T., Perisa, M. M., Barisic, I., Radic, B., Milanovic, K., Drmic, D., Seiwerth, S., & Sikiric, P. (2021). BPC-157 as a Therapy for Retinal Ischemia Induced by Retrobulbar Application of L-NAME in Rats. Frontiers in pharmacology, 12, 632295. https://doi.org/10.3389/fphar.2021.632295 https://pubmed.ncbi.nlm.nih.gov/34177567/
77. Masnec, S., Kokot, A., Zlatar, M., Kalauz, M., Kunjko, K., Radic, B., Klicek, R., Drmic, D., Lazic, R., Brcic, L., Radic, R., Ivekovic, R., Seiwerth, S., & Sikiric, P. (2015). Perforating corneal injury in rat and pentadecapeptide BPC-157. Experimental eye research, 136, 9-15. https://doi.org/10.1016/j.exer.2015.04.016 https://pubmed.ncbi.nlm.nih.gov/25912999/
78. Lee, E., & Padgett, B. (2021). Intra-Articular Injection of BPC-157 for Multiple Types of Knee Pain. Alternative therapies in health and medicine, 27(4), 8-13. https://pubmed.ncbi.nlm.nih.gov/34324435/
79. Jung, Y. H., Kim, H., Kim, H., Kim, E., Baik, J., & Kang, H. (2022). The anti-nociceptive effect of BPC-157 on the incisional pain model in rats. Journal of dental anesthesia and pain medicine, 22(2), 97-105. https://doi.org/10.17245/jdapm.2022.22.2.97 https://pubmed.ncbi.nlm.nih.gov/35449779/
80. Sikiric, P., Seiwerth, S., Grabarevic, Z., Rucman, R., Petek, M., Jagic, V., Turkovic, B., Rotkvic, I., Mise, S., Zoricic, I., Konjevoda, P., Perovic, D., Simicevic, V., Separovic, J., Hanzevacki, M., Ljubanovic, D., Artukovic, B., Bratulic, M., Tisljar, M., Rekic, B., ... Buljat, G. (1997). Pentadecapeptide BPC-157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in rats. Journal of physiology, Paris, 91(3-5), 113-122. https://doi.org/10.1016/s0928-4257(97)89474-0 https://pubmed.ncbi.nlm.nih.gov/9403784/
81. Rasic, D., Zenko Sever, A., Rasic, F., Strbe, S., Rasic, Z., Djuzel, A., Duplancic, B., Boban Blagaic, A., Skrtic, A., Seiwerth, S., Sikiric, P., & Sever, M. (2021). Stable Gastric Pentadecapeptide BPC-157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats. Biomedicines, 9(9), 1206. https://doi.org/10.3390/biomedicines9091206 https://pubmed.ncbi.nlm.nih.gov/34572392/
82. Tkalcević, V. I., Cuzić, S., Brajsa, K., Mildner, B., Bokulić, A., Situm, K., Perović, D., Glojnarić, I., & Parnham, M. J. (2007). Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression. European journal of pharmacology, 570(1-3), 212-221. https://doi.org/10.1016/j.ejphar.2007.05.072 https://pubmed.ncbi.nlm.nih.gov/17628536/
83. Sucic, M., Luetic, K., Jandric, I., Drmic, D., Sever, A. Z., Vuletic, L. B., Halle, Z. B., Strinic, D., Kokot, A., Seiwerth, R. S., Zoricic, I., Blagaic, A. B., Seiwerth, S., & Sikiric, P. (2019). Therapy of the rat hemorrhagic cystitis induced by cyclophosphamide. Stable gastric pentadecapeptide BPC-157, L-arginine, L-NAME. European journal of pharmacology, 861, 172593. https://doi.org/10.1016/j.ejphar.2019.172593 https://pubmed.ncbi.nlm.nih.gov/31401154/
84. Smoday, I. M., Petrovic, I., Kalogjera, L., Vranes, H., Zizek, H., Krezic, I., Gojkovic, S., Skorak, I., Hriberski, K., Brizic, I., Kubat, M., Strbe, S., Barisic, I., Sola, M., Lovric, E., Lozic, M., Boban Blagaic, A., Skrtic, A., Seiwerth, S., & Sikiric, P. (2022). Therapy Effect of the Stable Gastric Pentadecapeptide BPC-157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats. Biomedicines, 10(6), 1299. https://doi.org/10.3390/biomedicines10061299 https://pubmed.ncbi.nlm.nih.gov/35740321/