Background: 背景：
Yes, in the European countries Mebendazole can be found on the supermarket shelves.
是的，在欧洲国家，可以在超市货架上找到甲苯咪唑。
Mebendazole is an anthelmintic drug that has been used since the early 1970s to treat a range of parasitical worm infections, including threadworm, tapeworms, roundworms, and other nematode and trematode infections in humans and domestic animals (Ref.). The drug is among those on the World Health Organization’s list (WHO) (Ref.).
甲苯咪唑是一种驱虫药，自 20 世纪 70 年代初以来一直用于治疗多种寄生虫感染，包括蛲虫、绦虫、蛔虫以及人类和家畜的其他线虫和吸虫感染（ 参考文献 ）。该药物已被列入世界卫生组织（WHO）的药物清单（ 参考文献 ）。
Mebendazole became and remained one of my preferred drugs since I learned about it at the beginning of 2014. This was mainly due to the multiple strong points that are defining Mebendazole. Those strong points are:
自从2014年初了解到甲苯咪唑以来，它就一直是我的首选药物之一。这主要归功于甲苯咪唑的诸多优点。这些优点包括：
- it has high potential for serious effectiveness against cancer supported by both
它对癌症具有很高的疗效潜力，并且- a large number of scientific publications (Ref.) and
大量的科学出版物（ 参考文献 ）和 - clear case reports in humans, where, Mebendazole alone was effective in inducing cancer regression, in cancer patients with adrenal cancer (Ref.) and colorectal cancer (Ref.), not responding anymore to conventional treatment methods
人类病例报告显示，单独使用甲苯咪唑即可有效诱导肾上腺癌（ 参考文献 ）和结直肠癌（ 参考文献 ）患者的癌症消退，而这些患者对常规治疗方法不再有反应
- a large number of scientific publications (Ref.) and
- it has nearly no side effects, and due to this reason
它几乎没有副作用，因此 - it is an over the counter drug in most of the countries, which means there is no need for a doctor prescription
在大多数国家，它是一种非处方药，这意味着不需要医生处方 - and on top of all, it is a very cheap drug
最重要的是，它是一种非常便宜的药物 - available virtually anywhere and everywhere.
几乎可以在任何地方使用。
The first website where I came across Mebendazole discussion was, I think, this one: http://www.abovetopsecret.com/forum/thread822776/pg1 I was happy to see in 2014, just a few months latter after I studied Mebendazole intensively and became convinced about its anti cancer relevance, a paper has come out from one of my favorite Anti Cancer Foundation, i.e. Anticancer Fund, consolidating a good amount of research and proposing Mebendazole as a re-purposed drug against cancer. Here is that nice paper published in 2014: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/ By that time, we were already using it.
我记得我第一次看到关于甲苯咪唑的讨论的网站是这个： http://www.abovetopsecret.com/forum/thread822776/pg1。2014 年 ，在我深入研究甲苯咪唑并确信其抗癌功效几个月后，我很高兴地看到一篇论文，它来自我最喜欢的抗癌基金会之一—— 抗癌基金 ，该基金会整合了大量研究成果，并建议将甲苯咪唑作为一种新的抗癌药物。这篇发表于 2014 年的论文很棒： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/ 那时候，我们已经在用它了。
Before and after the publication of the above paper by Anticancer Fund, there were multiple relevant scientific papers published around Mebendazole and multiple discussions, triggering me to start writing about Mebendazole.
在抗癌基金发表上述论文前后，出现了多篇围绕甲苯咪唑的相关科学论文和多次讨论，促使我开始撰写有关甲苯咪唑的文章。
Interestingly and amazingly, in 2016, a drug company has decided to charge 200x higher price for Mebendazole (thanks to Helga, a reader of this website I learned about this) (Ref.). Fortunately, it seems that in the US there is still available a powder form that is cheap. Alternatively, it can anyway be ordered online as discussed below in the “Source” section. This was another point when I wanted to write about Mebendazole.
有趣且令人惊讶的是，2016 年，一家制药公司竟然将甲苯咪唑的价格提高了 200 倍（感谢本网站的读者 Helga，我才知道这件事）（ 参考文献 ）。幸运的是，在美国似乎仍然有一种价格低廉的粉剂。或者，您也可以按照下文“来源”部分所述，在线订购。这也是我想写关于甲苯咪唑的另一个原因。
Today, finally, I succeeded to write this post, triggered again by another publication coming from US Oncology center and School of Medicine, suggesting the re-purposing of Mebendazole as a replacement for Vincristine chemotherapy for the treatment of Brain tumors (Ref.).
今天，我终于成功地写了这篇文章，这又一次受到来自美国肿瘤中心和医学院的另一份出版物的启发，该出版物建议重新使用甲苯咪唑作为长春新碱化疗的替代品，用于治疗脑肿瘤（ 参考文献 ）。
Credit photo: https://valelab.ucsf.edu/research/microtubules/
图片来源： https://valelab.ucsf.edu/research/microtubules/
While many of the constant readers of this website already know Mebendazole, I hope the article will help the awareness of new readers.
虽然本网站的许多常客已经了解甲苯咪唑，但我希望这篇文章能够帮助新读者提高认识。
Indeed, Mebendazole, alone or combined with chemo, has been shown to be effective against multiple forms of cancer cells, such as:
事实上，甲苯咪唑单独使用或与化疗联合使用均已被证实可有效对抗多种癌细胞，例如：
- adrenal cancer (Ref.1, Ref.2)
肾上腺癌（ 参考文献 1、 参考文献 2） - colon cancer (Ref.1, Ref.2)
结肠癌（ 参考文献 1、 参考文献 2） - brain cancer, medulloblastoma, glioblastoma (Ref.1, Ref.2, Ref.3, Ref.4)
脑癌、髓母细胞瘤、胶质母细胞瘤（ 参考文献 1、 参考文献 2、 参考文献 3、 参考文献 4） - melanoma (Ref.1, Ref.2, Ref.3)
黑色素瘤（ 参考文献 1、 参考文献 2、 参考文献 3） - head and neck squamous cell carcinoma (HNSCC) (Ref.)
头颈部鳞状细胞癌（HNSCC）（ 参考 ） - cholangiocarcinoma or bile duct cancer (Ref.)
胆管癌或胆管癌（ 参考 ） - gastric cancer (Ref.)
胃癌（ 参考文献 ） - breast cancer (Ref.)
乳腺癌（ 参考文献 ） - lung cancer (Ref.1, Ref.2)
肺癌（ 参考文献 1、 参考文献 2） - ovarian (Ref.)
卵巢（ 参考 ） - leukemia (Ref.) acute myeloid leukemia (AML) (Ref.)
白血病（ 参考 ） 急性髓细胞白血病（AML）（ 参考 ） - pancreatic cancer (Ref.)
胰腺癌（ 参考文献 ） - fibrosarcoma (Ref.)
纤维肉瘤（ 参考 ）
A study, showed a high level of activity against leukaemia, colon cancer, CNS and melanoma cell lines, with lesser activity in breast, ovarian, renal and NSCLC lines (Ref.).
一项研究表明，它对白血病、结肠癌、中枢神经系统和黑色素瘤细胞系具有高活性，但对乳腺癌、卵巢癌、肾癌和非小细胞肺癌细胞系的活性较低（ 参考文献 ）。
Based on all the research available, I would expected the highest chance of effectiveness of Mebendazole, against
根据所有可用的研究，我预计甲苯咪唑对
- adrenal cancer, 肾上腺癌，
- colon and colo-rectal cancer,
结肠癌和结直肠癌， - brain cancer, 脑癌，
- melanoma and 黑色素瘤和
- leukemia 白血病
and possibly 并且可能
- pancreatic cancer and 胰腺癌和
- lung cancer 肺癌
However, given the low cost, limited to now side effects, its availability and potential, I would still try it for the other cancer types (next to other treatments), specifically for the aggressive cancer types.
然而，考虑到其成本低、副作用有限、可用性和潜力，我仍然会尝试将其用于治疗其他类型的癌症（仅次于其他治疗方法），特别是针对侵袭性癌症类型。
Based on the above results, the other potentially responsive tumor types seem to be those of
根据上述结果，其他可能具有反应性的肿瘤类型似乎是
- ovarian, 卵巢，
- breast, 胸部，
- bile duct, 胆管，
- gastric. 胃的。
Note: other anthelmintic drugs have also been shown to present strong anti cancer effects, but their main anti cancer mechanisms may be different.
注：其他驱虫药也被证实具有较强的抗癌作用，但其主要抗癌机制可能不同。
Of the anthelmintic category, Albendazole is one of my other favorites due to its unique anti cancer mechanism (to be discussed elsewhere) but that comes with some liver toxicity. Albendazole has been indicated to be effective against, e.g. ovarian cancer (Ref.). Here is a study suggesting that of the existing repurposed drugs, antiparazite medication is one of the most effective group of drugs against cancer, after typical anti neoplastic drugs (Ref.).
在驱虫药类别中，阿苯达唑因其独特的抗癌机制（将在其他地方讨论）而成为我的另一大心头好，但这也伴随着一些肝毒性。阿苯达唑已被证明对卵巢癌等疾病有效（ 参考文献 ）。一项研究表明，在现有的再利用药物中，抗寄生虫药物是继典型的抗肿瘤药物之后，最有效的抗癌药物之一（ 参考文献 ）。
The ever growing evidence that anti parasitic medication is effective against cancers may also trigger medical doctors and researchers look at cancer from other perspectives, e.g. cancer as a parasitic disease, a perspective which so far has been only discussed outside the mainstream medicine.
越来越多的证据表明抗寄生虫药物对癌症有效，这也可能促使医生和研究人员从其他角度看待癌症，例如将癌症视为一种寄生虫病，这一观点迄今为止仅在主流医学之外进行讨论。
Here is an example that consolidated such a perspective http://jeffreydachmd.com/2016/05/cancer-as-a-parasitic-disease/ I think, successful researchers have to always keep their mind open, ready to consider new perspectives proposed by others and even better connect the available “dots” to generate new perspectives.
这里有一个例子巩固了这种观点 http://jeffreydachmd.com/2016/05/cancer-as-a-parasitic-disease/ 我认为，成功的研究人员必须始终保持开放的心态，随时准备考虑他人提出的新观点，甚至更好地将现有的“点”连接起来以产生新的观点。
As we will discuss further, the only drawback with Mebendazole is that due to its absorption which can be different in different patients, the results may vary from patient to patient.
正如我们将进一步讨论的那样，甲苯咪唑的唯一缺点是由于其在不同患者中的吸收情况可能不同，因此结果可能因患者而异。
According to recent research, Mebendazole may inhibit Multi Drug Resistence (MDR) transporters (Ref.). These are the transporters used by cancer cells to push out chemotherapies in order to survive during chemo treatments. Therefore, using Mebendazole during chemo treatments may lead to increase effectiveness of the conventional therapies.
根据最近的研究，甲苯咪唑可能抑制多药耐药性 (MDR) 转运蛋白（ 参考文献 ）。癌细胞正是利用这些转运蛋白来排出化疗药物，以便在化疗期间存活。因此，在化疗期间使用甲苯咪唑可能会提高常规疗法的疗效。
Case Reports in Humans: 人类病例报告：
Besides all the studies in the lab indicating the effectiveness of Mebendazole against various cancer types, below are two published scientific case reports that are clear and coming from trust-able sources.
除了实验室的所有研究表明甲苯咪唑对各种癌症类型的有效性之外，下面还有两份已发表的科学案例报告，这些报告清晰且来自可靠的来源。
In both cases, Mebendazole has been applied after the patients were not responding anymore to conventional therapies.
在这两起案件中，患者均对常规疗法不再有反应，因此使用了甲苯咪唑。
The medical doctors have decided to use Mebendazole following scientific results from various research groups suggesting Mebendazole may be effective for those cancer types. This indeed, was the case. The results were extremely promising:
医生们决定使用甲苯咪唑，是因为多个研究小组的科学结果表明，甲苯咪唑可能对这些类型的癌症有效。事实也确实如此。研究结果非常令人鼓舞：
Mebendazole monotherapy and long-term disease control in metastatic adrenocortical carcinoma https://www.ncbi.nlm.nih.gov/pubmed/21454232
甲苯咪唑单药治疗转移性肾上腺皮质癌的长期疾病控制 https://www.ncbi.nlm.nih.gov/pubmed/21454232
Here is a PDF version available.
这里有可用的 PDF 版本。
A 48-year-old man with adrenocortical carcinoma had disease progression with systemic therapies including mitotane, 5-fluorouracil, streptozotocin, bevacizumab, and external beam radiation therapy.
一名 48 岁的肾上腺皮质癌男性在接受米托坦、5-氟尿嘧啶、链脲佐菌素、贝伐单抗和外照射放射治疗等全身治疗后病情出现进展。
Treatment with all chemotherapeutic drugs was ceased, and he was prescribed mebendazole, 100 mg twice daily, as a single agent. His metastases initially regressed and subsequently remained stable.
医生停用所有化疗药物，仅给他开具甲苯咪唑单药，每次100毫克，每日两次。他的转移灶最初消退，随后保持稳定。
While receiving mebendazole as a sole treatment for 19 months, his disease remained stable. He did not experience any clinically significant adverse effects, and his quality of life was satisfactory. His disease subsequently progressed after 24 months of mebendazole monotherapy.
在接受甲苯咪唑单药治疗19个月期间，他的病情保持稳定。他没有出现任何临床显著的不良反应，生活质量令人满意。随后，在接受甲苯咪唑单药治疗24个月后，他的病情出现进展。
My comments: as discussed in the article, the patient received only 200mg Mebendazole each day. That to me is the lowest daily dose and according to multiple sources the dose could be further increased with no issues.
我的评论 ：正如文章中所讨论的，患者每天只服用 200 毫克甲苯咪唑。在我看来，这是最低的每日剂量，而且根据多个来源的信息，进一步增加剂量也不会有问题。
In addition, Mebendazole is known to be poorly absorbed in the body and there are ways to increase its absorption.
此外，众所周知，甲苯咪唑在人体的吸收率很差，有办法提高其吸收率。
All these will be further discussed in the “Dose and Application” section below, but the point is that while the medical doctors authors of this article have my highest regards, in the future higher dose can be used to try increase Mebendazole effectiveness.
所有这些都将在下面的“剂量和应用”部分进一步讨论，但重点是，虽然我对本文的医生作者表示最高的敬意，但将来可以使用更高的剂量来尝试提高甲苯咪唑的有效性。
Drug repositioning from bench to bedside: tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer. https://www.ncbi.nlm.nih.gov/pubmed/24160353
药物从实验室到临床的重新定位：抗蠕虫药物甲苯咪唑对难治性转移性结肠癌的肿瘤缓解作用。https ://www.ncbi.nlm.nih.gov/pubmed/24160353
Here is a PDF version available.
这里有可用的 PDF 版本。
A patient with refractory metastatic colon cancer was treated with MBZ at the standard anthelmintic dose of 100 mg twice daily.
一名患有难治性转移性结肠癌的患者接受了 MBZ 治疗，标准驱虫剂量为每天两次，每次 100 毫克。
The patient experienced no subjective adverse effects at all from the drug and computerized tomography evaluation after six weeks of therapy showed near complete remission of the metastases in the lungs and lymph nodes and a good partial remission in the liver.
患者没有感受到任何由药物引起的主观不良反应，经过六周的治疗后，计算机断层扫描评估显示肺部和淋巴结转移几乎完全缓解，肝脏转移也得到良好的部分缓解。
At this stage, the liver enzymes AST and ALT were found elevated up to five and seven times above upper limit of normal and mebendazole was temporarily stopped and then reintroduced at half dose.
在此阶段，发现肝酶 AST 和 ALT 升高至正常上限的五倍和七倍，因此暂时停止使用甲苯咪唑，然后以一半的剂量重新开始使用。
Liver enzymes slowly decreased and the patient still reported no adverse effects from mebendazole. The disease was stable at a new CT, confirming the response observed earlier.
肝酶缓慢下降，患者仍未报告甲苯咪唑的不良反应。再次 CT 扫描时病情稳定，证实了先前观察到的疗效。
My comments: Since Mebendazole is not associated with hepatic dysfunction (Ref.) and since the daily dose used here is on the very low side, I suspect the elevation of AST and ALT was due to the tumor lysis.
我的评论： 由于甲苯咪唑与肝功能障碍无关（ 参考文献 ），并且这里使用的每日剂量非常低，我怀疑 AST 和 ALT 升高是由于肿瘤溶解引起的。
Mechanism: 机制：
The primary anti cancer mechanism is related to the depolymerization of tubulin in human tumor cells caused by Mebendazole, inhibiting mitotic spindle formation, and therefore inducing mitotic arrest and apoptosis. This is a mechanism similar to that one I already described in details in the post on Griseofulvin: https://www.cancertreatmentsresearch.com/decide/ so I will not discuss again, here, the details of the mechanism.
其主要的抗癌机制与甲苯咪唑导致人类肿瘤细胞微管蛋白解聚有关， 从而抑制有丝分裂纺锤体的形成 ，进而诱导有丝分裂停滞和细胞凋亡。这种机制与我在关于灰黄霉素的文章 https://www.cancertreatmentsresearch.com/decide/ 中详细描述的机制类似，因此在此不再赘述。
Indeed, Mebendazole has been shown to cause mitotic arrest in parasitic cells as early as 197o’s (e.g. Ref.). As a reference for the reader, at some level, Mebendazole acts similar to microtubule dynamic inhibiting chemotheraphies such as microtubule-stabilizing (e.g., paclitaxel, docetaxel) or microtubule-destabilizing (e.g., vinblastine, vincristine, nocodazole, colchicine) agents (Ref.)
事实上，早在 20 世纪 70 年代，甲苯咪唑就已被证实能够导致寄生虫细胞有丝分裂停滞（例如参考文献 ）。供读者参考，在某种程度上，甲苯咪唑的作用类似于抑制微管动力学的化疗药物，例如稳定微管的药物（ 例如紫杉醇、多西他赛）或不稳定微管的药物（ 例如长春花碱、长春新碱、诺考达唑、秋水仙碱）（ 参考文献 ）。
Mebendazole has been found to work against tumors via other mechanisms as well:
研究发现，甲苯咪唑还能通过其他机制对抗肿瘤：
- angiogenesis inhibition (Ref.) MBZ may inhibit the action of VEGFR-2 by binding to it (Ref.)
血管生成抑制 （ 参考文献 ）MBZ 可能通过与 VEGFR-2 结合来抑制其作用（ 参考文献 ） - inactivates Bcl-2 and activates caspases to promote apoptosis in cancer cells, and the release of cytochrome c, which has also been shown to trigger apoptosis in malignant cells (Ref.). Here is how Bcl-2 fits into the picture (Ref.).
抑制 Bcl-2 并激活胱天蛋白酶（caspase），从而促进癌细胞凋亡，并释放细胞色素 c，而细胞色素 c 已被证实可引发恶性细胞凋亡（ 参考文献 ）。Bcl-2 在其中发挥的作用如下（ 参考文献 ）。 - hedgehog inhibitor (Hh) (Ref.) Here is how hedgehog fits into the picture (Ref.). The hedgehog (Hh) signaling pathway is activated in many types of cancer and therefore presents an attractive target for new anticancer agents.
Hedgehog 抑制剂 （Hh）（ 参考文献 ）。Hedgehog 在图中的作用机制如下（ 参考文献 ）。Hedgehog（Hh）信号通路在多种癌症中被激活，因此成为新型抗癌药物的一个有吸引力的靶点。
Hedgehog ligands or markers of downstream pathway activity have been detected in melanomas, lung cancers, ovarian cancers, adrenocortical cancers and colorectal cancers (Ref.), which are all responsive to Mebendazole, as discussed above. Interestingly, among other Hedgehog inhibitors that have previously identified are also drugs that interact with microtubules, including vinblastine, vincristine, and paclitaxel (Ref.). Itraconazole, that I previously discussed in a different post is also a hedgehog inhibitor: https://www.cancertreatmentsresearch.com/itraconazole/ So there may be a connection between hedgehog inhibition and microtubule dynamics inhibition.
如上所述，在黑色素瘤、肺癌、卵巢癌、肾上腺皮质癌和结直肠癌中均检测到了 Hedgehog 配体或下游通路活性标记（ 参考文献 ），这些癌症均对甲苯咪唑有反应。有趣的是，此前已鉴定的其他 Hedgehog 抑制剂中，也包括与微管相互作用的药物，包括长春花碱、长春新碱和紫杉醇（ 参考文献 ）。我之前在另一篇文章中讨论过的伊曲康唑也是一种 Hedgehog 抑制剂： https://www.cancertreatmentsresearch.com/itraconazole/ 因此，Hedgehog 抑制和微管动力学抑制之间可能存在联系。 - based on the fact that ultra low dose microtubule inhibiting chemotherapy is known to activate the immune system, (https://www.cancertreatmentsresearch.com/ultra-low-dose-taxol/) it has been proposed that Mebendazole could do the same (Ref.) Update 2020 August: here is a recent paper suggesting immune activation due to ERK mediated immune cell activation (Ref.)
基于已知超低剂量微管抑制化疗能够激活免疫系统这一事实，（ https://www.cancertreatmentsresearch.com/ultra-low-dose-taxol/ ）有人提出甲苯咪唑也能起到同样的作用（ 参考文献 ） 2020 年 8 月更新： 这是一篇最近的论文，表明由于 ERK 介导的免疫细胞激活而导致的免疫激活（ 参考文献 ）
Interestingly, Mebendazole is not toxic against normal cells. Researchers speculated a defect in at least one mitotic checkpoint function in tumor cells leading to their higher sensitivity to Mebendazole (Ref.).
有趣的是，甲苯咪唑对正常细胞无毒性。研究人员推测，肿瘤细胞至少存在一个有丝分裂检查点的功能缺陷，导致其对甲苯咪唑的敏感性更高（ 参考文献 ）。
Update November 2017: Here is an article, published this month, presenting a diagram with Mebendazole’s anti cancer mechanisms known so far: https://www.tjpr.org/admin/12389900798187/2017_16_10_32.pdf
2017 年 11 月更新：这是本月发表的一篇文章，其中展示了迄今为止已知的甲苯咪唑抗癌机制的图表： https://www.tjpr.org/admin/12389900798187/2017_16_10_32.pdf
Side effects: 副作用：
In general, the drug is well tolerated but some people may present adverse effects and may have to discontinue. Here is the product description https://www.janssen.com/canada/sites/www_janssen_com_canada/files/product/pdf/ver11192014cpm.pdf
总体而言，该药物耐受性良好，但部分患者可能出现不良反应，需要停药。产品说明如下： https://www.janssen.com/canada/sites/www_janssen_com_canada/files/product/pdf/ver11192014cpm.pdf
At high dose, it has been found to possibly induce bone marrow suppression in patients chronic liver disease (Ref.) That reverted to normal after the drug was stopped. There are rare reports of reversible alopecia, urticaria, rash, gastro-intestinal upset, leukopenia, and neutropenia in some patients treated with high-dose MBZ (Ref.)
大剂量服用 MBZ 可能在慢性肝病患者中引发骨髓抑制（ 参考文献 ），停药后病情恢复正常。罕见报告显示，部分接受大剂量 MBZ 治疗的患者出现可逆性脱发、荨麻疹、皮疹、胃肠不适、白细胞减少和中性粒细胞减少（ 参考文献 ）。
MBZ is contraindicated during pregnancy, due to its potential anti-angiogenesis properties.
由于 MBZ 具有潜在的抗血管生成特性，因此在怀孕期间禁用。
In the event of accidental overdose, abdominal cramps, nausea, vomiting and diarrhea may occur (Ref.).
如果意外服用过量，可能会出现腹部绞痛、恶心、呕吐和腹泻（ 参考 ）。
Promotion: Please consider our Food Supplements Shop MCS Formulas – Quality, Purity, Strength – it comes with Trust & Expertise and we Donate 50% for Cancer Patients
促销： 请考虑我们的食品补充剂商店 MCS 配方 - 质量、纯度、强度 - 它来自信任和专业知识，我们为癌症患者捐赠 50%
MCS Formulas is a food supplement company founded by members of Cancer Treatments Research community. It’s goal is to deliver value to the world in two major ways:
MCS Formulas 是一家由癌症治疗研究社区成员创立的食品补充剂公司。公司的目标是通过以下两个主要方式为世界创造价值：
- deliver some of the best product combination of Purity, Strength and Fair Price (as well as Compiled Packages). We often focus on single compounds and did the best to remove excipients, maximise active ingredients in a capsule, and increase bio-availability;
提供纯度、强度和合理价格（以及精心设计的包装）的最佳产品组合。我们通常专注于单一化合物，并尽力去除赋形剂，最大限度地提高胶囊中的活性成分，并提高生物利用度；
. - donate 50% of our profits to projects to accelerate the transfer of value from traditional medicine and/or academic space to clinical space, to enable new treatments for cancer patients.
将我们 50% 的利润捐赠给加速从传统医学和/或学术领域向临床领域价值转移的项目，为癌症患者提供新的治疗方法。
(We will use a third party audit to monitor that this is what we are going to do as soon as we will be able to do it.) The remaining 50% will help MCS Formulas to be healthy, grow, and be able to contribute more.
（我们将使用第三方审计来监控这是我们在能够做到的时候会做的事情。）剩下的 50% 将帮助 MCS Formulas 保持健康、成长并能够做出更多贡献。
Below is an image that consolidates the value MCS Formulas delivers through its products and actions, which comes with TRUST and FAIRNESS.
下面的图片巩固了 MCS Formulas 通过其产品和行动所传递的价值，即信任和公平。
Dose and Administration: 剂量和用法：
One of the challenge with Mebendazole administrations is its low bioavailability which leads to only 20% absorption. The mebendazole plasma concentration-time profiles differed considerably between patients receiving 10 mg/kg Mebendazole; elimination half-lives ranged from 2.8-9.0 h, time to peak plasma concentration after dosing ranged from 1.5-7.25 h and peak plasma concentrations ranged from 17.5 to 500 ng/ml.
甲苯咪唑给药的挑战之一是其生物利用度低，导致吸收率仅为 20%。接受 10 mg/kg 甲苯咪唑的患者，其血浆浓度-时间曲线差异显著：消除半衰期为 2.8-9.0 小时，服药后血浆浓度达峰时间范围为 1.5-7.25 小时，血浆峰浓度范围为 17.5 至 500 ng/ml。
(Ref.) Such doses are indeed in the plasma level reported to achieve anti cancer effects in the lab. Hoewever, as it can be seen the distribution of plasma level is wide so not everyone will reach high plasma level of Mebendazole.
（ 参考文献 ）实验室报道显示，此类剂量确实达到了血浆水平，能够达到抗癌效果。然而，正如所见，血浆浓度分布范围很广，因此并非每个人都能达到较高的甲苯咪唑血浆浓度。
Therefore, to address the challenge related to reaching a high level of mebendazole plasma level, which on one hand is due to the bad absorption and on the other hand due to a strong first pass metabolism in the liver, the following actions can be taken:
因此，为了解决与达到高甲苯咪唑血浆水平相关的挑战，一方面是由于吸收不良，另一方面是由于肝脏的首过代谢强烈，可以采取以下措施：
- administer with a fatty meal (Ref.)
与高脂肪食物一起服用（ 参考 ） - long term administration (Ref.)
长期管理（ 参考 ） - increased dose may increase the absorption (Ref.)
增加剂量可能会增加吸收（参考） - given with Cimetidine (another of my preferred anti cancer drugs) (Ref.) will reduce its metabolism in the liver. Cimetidine can be found as an over the counter drug on eBay but should be used with care when combined with chemo as it will increase the plasma level of some of the chemos.
与西咪替丁（我另一种常用的抗癌药物）合用（ 参考文献 ）会降低其在肝脏的代谢。西咪替丁可以在 eBay 上买到，但与化疗药物合用时应谨慎，因为它会增加某些化疗药物的血浆浓度。
The low bioavailability is also probably why its side effects are very limited. Mebendazole is rapidly metabolized to less toxic metabolites by the liver, and this could be another reason for its low toxicity (Ref.). Increasing the plasma level with the strategy mentioned above, may also bring some side effects, so have an eye on that.
生物利用度低也可能是其副作用非常有限的原因。甲苯咪唑在肝脏中快速代谢为毒性较低的代谢物，这可能是其毒性较低的另一个原因（ 参考文献 ）。采用上述策略提高血浆浓度也可能带来一些副作用，因此需谨慎考虑。
According to the literature, some people may absorb better Mebendazole compared to other, that may also lead to different effectiveness of Mebendazole in different people.
根据文献，有些人对甲苯咪唑的吸收可能比其他人更好，这也可能导致甲苯咪唑对不同人的有效性不同。
In the two successful case reports referenced above, the patients have used the minimum dose typically used against worms, i.e. 100mg 2x/day.
在上述两份成功病例报告中，患者使用了通常用于治疗蠕虫的最低剂量，即每天两次，每次 100 毫克。
This, to my opinion is on the low side of the dose but could be the starting dose. A high dose, but still feasible, according to a World Health Organisation reference (Ref.) cited by the Anticancer Fund (Ref.), could be up to of 40–50 mg/kg/day for at least 3–6 months. This seems to be the long-term treatment of cystic echinococcosis.
在我看来，这个剂量偏低，但可以作为起始剂量。根据抗癌基金会（ Ref.）引用的世界卫生组织参考文献（Ref . ），高剂量（但仍然可行）可以达到每天每公斤体重 40-50 毫克，持续至少 3-6 个月。这似乎是囊型包虫病的长期治疗方案。
Another reference in terms of max dose still feasible is that used for alveolar echinococcosis, where 40–50 mg/kg/day is used with treatment for at least two years, and possibly longer for patients with inoperable disease (Ref.).
就最大剂量而言仍然可行的另一个参考是用于治疗泡型包虫病的剂量，其中使用 40-50 mg/kg/天治疗至少两年，对于无法手术的患者，治疗时间可能更长（ 参考文献 ）。
Based on the above, a person of 50kg could use up to 2.5g Mebendazole for months to years. Actually, this website pointed out a discussion on Inspire website where a caregiver said a brain cancer patient accessing a clinical trial at John Hopkins Hospital was “taking 2500mg in the morning, 3000 mg in the afternoon & evening.” (Ref.) That is really a huge dose.
基于上述情况，一个体重 50 公斤的人可能需要服用高达 2.5 克的甲苯咪唑，持续数月甚至数年。事实上， 该网站指出， Inspire 网站上的一篇讨论中，一位护理人员提到，一位在约翰·霍普金斯医院参加临床试验的脑癌患者“早上服用 2500 毫克，下午和晚上分别服用 3000 毫克”。( 参考文献 ) 这确实是个大剂量。
Indeed, there was a clinical trial at John Hopkins Hospital, involving Mebendazole for Brain cancer gave it at 3x500mg/day with meals, on a 28 day cycle (Ref.). I haven’t found yet the results reported.
确实，约翰·霍普金斯医院曾进行过一项临床试验，试验对象是脑癌患者，每日服用 3 次，每次 500 毫克，随餐服用，28 天为一个周期（ 参考文献 ）。我还没有找到报告的结果。
Following the above discussions, I would take the daily dose split into two, during or just after breakfast and dinner, if possible together with Cimetidine 400mg 2x/day. I would always start with a low dose Mebendazole and go up step by step to the target dose.
按照以上讨论，我会将每日剂量分成两次服用，分别在早餐和晚餐时或之后服用，如果可能的话，可以同时服用西咪替丁 400 毫克，每日两次。我总是从低剂量的甲苯咪唑开始，然后逐步增加到目标剂量。
If the target dose is very high, I would split that in 3x/day. Also, please note that in the clinical trail they did not used Cimetidine.
如果目标剂量很高，我会分成每天三次服用。另外，请注意，临床试验中他们没有使用西咪替丁。
And since Cimetidine may very much increase the plasma level of Mebendazole (some say by 50%), in case we use that I would make sure the target dose is lower than what was used at John Hopkins Hospital.
由于西咪替丁可能会大大增加甲苯咪唑的血浆水平（有人说增加 50%），如果我们使用该药物，我会确保目标剂量低于约翰霍普金斯医院使用的剂量。
Janssen Pharma product descriptions states the following regarding the dose: “In controlled safety studies, humans have received from 100 to 1200 mg of mebendazole daily for up to 14 days with no reported side effects.” (Ref.)
杨森制药 (Janssen Pharma) 的产品说明中对剂量进行了如下说明：“在受控安全研究中，人类每天服用 100 至 1200 毫克甲苯咪唑，连续服用 14 天，未报告任何副作用。”（ 参考 ）
Update Nov 2019: 2019年11月更新：
Here are two clinical trials on Mebendazole:
以下是两项关于甲苯咪唑的临床试验：
- A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas https://clinicaltrials.gov/ct2/show/NCT01837862 giving the following doses to the patients: 50 mg/kg/day, 100 mg/kg/day, or 200 mg/kg/day
甲苯咪唑治疗儿童胶质瘤的 I 期研究 https://clinicaltrials.gov/ct2/show/NCT01837862 为患者提供以下剂量：50 mg/kg/天、100 mg/kg/天或 200 mg/kg/天 - Mebendazole in Newly Diagnosed High-Grade Glioma Patients Receiving Temozolomide (Mebendazole https://clinicaltrials.gov/ct2/show/NCT01729260 giving the following doses to the patients: 3x/day 500mg with meals
接受替莫唑胺（甲苯咪唑 https://clinicaltrials.gov/ct2/show/NCT01729260 ）治疗的新诊断高级别胶质瘤患者的甲苯咪唑，给予患者以下剂量：3x/天，每次 500 毫克，随餐服用
Although a dose of 50 mg/kg/day seems very high, here is a man reporting that his son takes a very high dose of mebendazole as a part of a clinical trial, using 4.5g/day without significant side effects (Ref.).
尽管 50 mg/kg/天的剂量似乎很高， 但有一位男士报告说，他的儿子在临床试验中服用了非常高剂量的甲苯咪唑，每天使用 4.5g，没有出现明显的副作用（ 参考文献 ）。
Update July 2020: Here is a nice old article discussing the following:
2020 年 7 月更新： 这是一篇很好的旧文章，讨论以下内容：
“Mebendazole levels were measured in our patient 1 (Table).
“我们测量了患者 1 的甲苯咪唑水平（表格）。
To the best of our knowledge, previous reports of side effects have not included data on these levels; such measurements, however, may be important because of the drug’s erratic intestinal absorption and possible dose-related toxic effects.
据我们所知，以前的副作用报告没有包括这些水平的数据；然而，由于该药物的肠道吸收不稳定以及可能存在剂量相关的毒性作用，这种测量可能很重要。
Fasting levels measured in 22 patients receiving 16 to 48 mg/kg/day ranged from undetectable to 300 ng/mL.6 Only 19% of the levels exceeded 75 ng/mL, and levels did not correlate with dosages.6 Our first patient’s random and fasting levels were 147 to 239 ng/mL.
22 名接受 16 至 48 mg/kg/天剂量治疗的患者测得的空腹水平范围从检测不到到 300 ng/mL。6 只有 19% 的水平超过 75 ng/mL，并且水平与剂量无关。6 我们的第一位患者的随机和空腹水平为 147 至 239 ng/mL。
High levels have also been reported in a patient with cholestatic jaundice, presumably reflecting decreased hepatic metabolism, the primary route for elimination of mebendazole.1 In our two patients and in the two previous patients described with neutropenia,45 either extensive liver replacement by cysts or underlying liver disease was noted and may have predisposed to high levels of mebendazole or its metabolites.7” https://pubmed.ncbi.nlm.nih.gov/6842806/
患有胆汁淤积性黄疸的患者也报告了高水平的甲苯咪唑或其代谢物，这可能反映了肝脏代谢的降低，而肝脏代谢是甲苯咪唑消除的主要途径。1 在我们的两名患者和之前描述的两名患有中性粒细胞减少症的患者中，45 都观察到肝脏被囊肿广泛取代或存在潜在的肝脏疾病，这些可能导致甲苯咪唑或其代谢物的水平升高。7” https://pubmed.ncbi.nlm.nih.gov/6842806/
This demonstrated the need to do our best to increase the blood levels of Mebendazole by increasing its absorption (taking it with fats) and lowering its metabolism (with Cimetidine/Tgamet).
这表明我们需要尽最大努力通过增加其吸收（与脂肪一起服用）和降低其代谢（与西咪替丁/Tgamet 一起服用）来提高甲苯咪唑的血液浓度。
Source: 来源：
The brand name is Vermox, Benda, etc. sold as a solution or tablet. I prefer the tablet version. Those tablets come in 100mg or 500mg version. I prefer the 500mg version and cut them in pieces if lower dose is required.
品牌名称是 Vermox、Benda 等，以溶液或片剂形式出售。我更喜欢片剂。这些片剂有 100 毫克和 500 毫克两种规格。我更喜欢 500 毫克的，如果需要较低剂量，可以切成小块。
Mebendazole is available at many pharmacies in many countries, online and over the counter. Here is an example of a version that is available over the counter at a super market in the Netherlands: https://www.kruidvat.nl/kruidvat-anti-worm-mebendazol-100mg-tabletten/p/1023933 . In this case 6x100mg tablets costs 3 euro.
甲苯咪唑在许多国家的药店都有售，包括线上药店和柜台药店。以下是荷兰超市柜台出售的甲苯咪唑版本的示例： https://www.kruidvat.nl/kruidvat-anti-worm-mebendazol-100mg-tabletten/p/1023933。6 片 100 毫克的药片售价为 3 欧元。
Another option is to buy from eBay or from sites like this one: http://smartproduct4u.com/?ref=285 many of which are coming from Thailand.
另一种选择是从 eBay 或类似这样的网站购买： http://smartproduct4u.com/?ref= 285 其中很多来自泰国。
Finally, if there is no other option or would like to go the low cost version, we can buy it from China, via Alibaba, at a cost of about 200 euro/kg if I remember correctly. But that is powder version. Btw, just think about this: 200 euro for 1000g in China vs.
最后，如果没有其他选择，或者想买便宜的版本，我们可以通过阿里巴巴从中国购买，如果我没记错的话，价格大约是每公斤200欧元。不过那是粉末状的。顺便说一句，想想看：在中国1000克要200欧元，而……
about 800.000 euro for 1000g in USA, after the price increase initiated by a US drug company last year. Imagine the gross profit on this one. How can, we, the society accept something like this???
去年一家美国制药公司发起涨价后，美国每1000克的价格约为80万欧元。想想这笔交易的毛利润有多大。我们社会怎么能接受这样的事情呢？
Other clinics recommending Mebendazole:
其他推荐甲苯咪唑的诊所：
Care Oncology Clinic in London, UK: http://careoncologyclinic.com/ They usually seem to give to their patients a combination of drugs including Sratin + Metformin + Doxycycline + Mebendazole. Here is an article explaining in details the price, activity and vision of this clinic http://www.telegraph.co.uk/wellbeing/health-advice/crowdfunding-cure-cancer/
英国伦敦的 Care Oncology Clinic： http://careoncologyclinic.com/ 他们通常会给病人开一些组合药物，包括 Sratin + 二甲双胍 + 强力霉素 + 甲苯咪唑。这里有一篇文章详细介绍了这家诊所的价格、业务和愿景 ：http://www.telegraph.co.uk/wellbeing/health-advice/crowdfunding-cure-cancer/
References: 参考：
Mebendazole monotherapy and long-term disease control in metastatic adrenocortical carcinoma https://www.ncbi.nlm.nih.gov/pubmed/21454232
甲苯咪唑单药治疗转移性肾上腺皮质癌的长期疾病控制 https://www.ncbi.nlm.nih.gov/pubmed/21454232
Repurposing Drugs in Oncology (ReDO)—mebendazole as an anti-cancer agent https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/
肿瘤学药物再利用 (ReDO)——甲苯咪唑作为抗癌剂 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/
Mebendazole, a well-known anti-helminthic drug in wide clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical studies across a number of different cancer types.
甲苯咪唑是一种在临床上广泛使用的著名抗蠕虫药物，它具有抗癌特性，这已在针对多种不同癌症类型的广泛临床前研究中得到阐明。
Significantly, there are also two case reports of anti-cancer activity in humans. The data are summarised and discussed in relation to suggested mechanisms of action.
值得注意的是，还有两例关于人类抗癌活性的病例报告。本文对相关数据进行了总结，并结合其可能的作用机制进行了讨论。
Based on the evidence presented, it is proposed that mebendazole would synergise with a range of other drugs, including existing chemotherapeutics, and that further exploration of the potential of mebendazole as an anti-cancer therapeutic is warranted.
根据所提供的证据，我们提出甲苯咪唑可以与包括现有化疗药物在内的一系列其他药物产生协同作用，并且有必要进一步探索甲苯咪唑作为抗癌治疗药物的潜力。
A number of possible combinations with other drugs are discussed in the Appendix.
附录中讨论了一些与其他药物的可能组合。
Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825534/
重新定位驱虫药甲苯咪唑用于治疗结肠癌 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825534/
Sixty-eight compounds were defined as hits with activity in both of these cell lines (<40 % cell survival compared with control) at 10 μM drug concentration.
在 10 μM 药物浓度下，68 种化合物在这两种细胞系中均有活性（与对照相比，细胞存活率 <40%）。
Analysis of chemical similarity of the hit compounds revealed several distinct clusters, among them the antiparasitic benzimidazole group. Two of these compounds, mebendazole (MBZ) and albendazole (ABZ) are registered for human use.
对命中化合物的化学相似性分析发现了几个不同的簇，其中包括抗寄生虫苯并咪唑类化合物。其中两种化合物，甲苯咪唑 (MBZ) 和阿苯达唑 (ABZ)，已注册用于人类。
Data from the NCI 60 cell line panel revealed only modest correlation between MBZ and ABZ, indicating differences in mechanism of action.
NCI 60 细胞系组的数据显示 MBZ 和 ABZ 之间仅有适度的相关性，表明作用机制存在差异。
This was further supported when gene expression signatures were compared in the CMAP database; ABZ ranked very low when MBZ was used as the query signature.
当在 CMAP 数据库中比较基因表达特征时，这一点得到了进一步的支持；当使用 MBZ 作为查询特征时，ABZ 的排名非常低。
Furthermore, MBZ, but not ABZ, was found to significantly interact with several protein kinases including BCR–ABL and BRAF. Analysis of the diagnosis-specific activity of MBZ showed activity in 80 % of the colon cancer cell lines in the NCI 60 panel.
此外，研究发现，MBZ（而非 ABZ）与多种蛋白激酶（包括 BCR-ABL 和 BRAF）有显著相互作用。对 MBZ 诊断特异性活性的分析显示，在 NCI 60 个样本中，80%的结肠癌细胞系存在 MBZ 活性。
Three additional colon cancer cell lines and three cell models with non-malignant phenotypes were subsequently tested, confirming selective colon cancer activity of MBZ. MBZ seemingly has repositioning potential for colorectal cancer therapy.
随后，研究人员对另外三种结肠癌细胞系和三种具有非恶性表型的细胞模型进行了测试，证实了 MBZ 对结肠癌的选择性活性。MBZ 似乎具有重新定位结直肠癌治疗的潜力。
Repurposing the antihelmintic mebendazole as a hedgehog inhibitor https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297232/
将抗蠕虫药甲苯咪唑重新用作刺猬抑制剂 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297232/
The hedgehog (Hh) signaling pathway is activated in many types of cancer and therefore presents an attractive target for new anticancer agents.
刺猬（Hh）信号通路在多种类型的癌症中被激活，因此成为新型抗癌药物的一个有吸引力的靶点。
Here we show that mebendazole (MBZ), a benzamidazole with a long history of safe use against nematode infestations and hydatid disease, potently inhibited Hh signaling and slowed the growth of Hh-driven human medulloblastoma cells at clinically attainable concentrations.
这里我们展示了甲苯咪唑 (MBZ)，一种具有长期安全用于对抗线虫感染和包虫病历史的苯并咪唑，在临床可达到的浓度下强效抑制 Hh 信号传导并减缓 Hh 驱动的人类髓母细胞瘤细胞的生长。
As an antiparasitic, MBZ avidly binds nematode tubulin and causes inhibition of intestinal microtubule synthesis. In human cells, MBZ suppressed the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for Hh pathway activation.
作为一种抗寄生虫药，MBZ 能与线虫微管蛋白紧密结合，并抑制肠道微管的合成。在人体细胞中，MBZ 抑制了初级纤毛的形成。初级纤毛是一种基于微管的细胞器，是 Hh 通路激活的信号中枢。
The inhibition of Hh signaling by MBZ was unaffected by mutants in the gene that encodes the Hh pathway signaling protein SMO, which are selectively propagated in cell clones that survive treatment with the Hh inhibitor vismodegib.
MBZ 对 Hh 信号的抑制不受编码 Hh 通路信号蛋白 SMO 的基因突变的影响，这些突变在用 Hh 抑制剂 vismodegib 治疗后存活的细胞克隆中选择性繁殖。
Combination of vismodegib and MBZ resulted in additive Hh signaling inhibition.
vismodegib 和 MBZ 的结合导致了 Hh 信号传导的附加抑制。
Because MBZ can be safely administered to adults and children at high doses over extended time periods, we propose that MBZ could be rapidly repurposed and clinically tested as a prospective therapeutic agent for many tumors that are dependent on Hh signaling.
由于 MBZ 可以安全地长期以高剂量给成人和儿童服用，我们认为 MBZ 可以快速重新利用并进行临床测试，作为依赖 Hh 信号传导的多种肿瘤的潜在治疗剂。
Combination of Manumycin A and Mebendazole in Human Breast Cancer Cell Lines, a PhD thesis from 2010 https://uh-ir.tdl.org/uh-ir/bitstream/handle/10657/166/HADDADIN-.pdf?sequence=2
Manumycin A 和甲苯咪唑在人类乳腺癌细胞系中的组合，2010 年的博士论文 https://uh-ir.tdl.org/uh-ir/bitstream/handle/10657/166/HADDADIN-.pdf?sequence=2
An article on Mebendazole, on a nice website of a breast cancer patient: https://magiccocktailquest.wordpress.com/2015/06/08/mebendazole/
一位乳腺癌患者的网站上有一篇关于甲苯咪唑的文章： https://magiccocktailquest.wordpress.com/2015/06/08/mebendazole/
Mebendazole is unique among tubulin-active drugs in activating the MEK–ERK pathway https://www.nature.com/articles/s41598-020-68986-0
甲苯咪唑在激活 MEK–ERK 通路方面是微管蛋白活性药物中独一无二的 https://www.nature.com/articles/s41598-020-68986-0
We recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity in monocyte/macrophage models and induces ERK signalling.
我们最近表明，抗蠕虫化合物甲苯咪唑 (MBZ) 在单核细胞/巨噬细胞模型中具有免疫调节活性并诱导 ERK 信号传导。
In the present study we investigated whether MBZ induced ERK activation is shared by other tubulin binding agents (TBAs) and if it is observable also in other human cell types.
在本研究中，我们调查了 MBZ 诱导的 ERK 激活是否被其他微管蛋白结合剂 (TBA) 所共有，以及它是否也可以在其他人类细胞类型中观察到。
Curated gene signatures for a panel of TBAs in the LINCS Connectivity Map (CMap) database showed a unique strong negative correlation of MBZ with MEK/ERK inhibitors indicating ERK activation also in non-haematological cell lines.
LINCS 连接图 (CMap) 数据库中针对一组 TBA 精心挑选的基因特征显示，MBZ 与 MEK/ERK 抑制剂之间存在独特的强负相关性，表明 ERK 也在非血液细胞系中被激活。
L1000 gene expression signatures for MBZ treated THP-1 monocytes also connected negatively to MEK inhibitors. MEK/ERK phosphoprotein activity testing of a number of TBAs showed that only MBZ increased the activity in both THP-1 monocytes and PMA differentiated macrophages.
MBZ 处理的 THP-1 单核细胞的 L1000 基因表达特征也与 MEK 抑制剂呈负相关。对多种 TBA 的 MEK/ERK 磷蛋白活性测试表明，只有 MBZ 能够同时提高 THP-1 单核细胞和 PMA 分化巨噬细胞中的活性。
Distal effects on ERK phosphorylation of the substrate P90RSK and release of IL1B followed the same pattern. The effect of MBZ on MEK/ERK phosphorylation was inhibited by RAF/MEK/ERK inhibitors in THP-1 models, CD3/IL2 stimulated PBMCs and a MAPK reporter HEK-293 cell line.
对底物 P90RSK 的 ERK 磷酸化和 IL1B 释放的远端效应也遵循相同的模式。在 THP-1 模型、CD3/IL2 刺激的 PBMCs 和 MAPK 报告基因 HEK-293 细胞系中，MBZ 对 MEK/ERK 磷酸化的影响被 RAF/MEK/ERK 抑制剂抑制。
MBZ was also shown to increase ERK activity in CD4+ T-cells from lupus patients with known defective ERK signalling.
研究还显示 MBZ 可以增加已知 ERK 信号传导缺陷的狼疮患者 CD4+ T 细胞中的 ERK 活性。
Given these mechanistic features MBZ is suggested suitable for treatment of diseases characterized by defective ERK signalling, notably difficult to treat autoimmune diseases.
鉴于这些机制特征，MBZ 被认为适用于治疗以 ERK 信号传导缺陷为特征的疾病，尤其是难以治疗的自身免疫性疾病。
Drug repurposing and relabeling for cancer therapy: Emerging benzimidazole antihelminthics with potent anticancer effects https://www.sciencedirect.com/science/article/abs/pii/S0024320520309413
药物重新利用和重新标记用于癌症治疗：具有强效抗癌作用的新兴苯并咪唑抗蠕虫药物 https://www.sciencedirect.com/science/article/abs/pii/S0024320520309413
Origin of drug and radio-refractory clones, cancer stem-like cells, and rapid angiogenesis and metastasis are among the primary concerns that limit the efficacy of anticancer treatments, emphasizing the urgency of developing new therapeutics.
药物和放射耐药性克隆的起源、癌症干细胞样细胞以及快速血管生成和转移是限制抗癌治疗疗效的主要问题，强调了开发新疗法的紧迫性。
Factors like high attrition rates, huge investments, patients’ heterogeneity, and diverse molecular subtypes have challenged the rapid development of anticancer drugs.
高流失率、巨额投入、患者异质性、分子亚型多样等因素对抗癌药物的快速发展提出了挑战。
Treatment with repurposing pleiotropic benzimidazole antihelminthics, like mebendazole, albendazole, and flubendazole has recently opened a new window, owing to their easy access, low cost as a generic drug, and long track record of safe use in the human population.
最近，利用甲苯咪唑、阿苯达唑和氟苯达唑等多效苯并咪唑类抗蠕虫药物进行治疗开辟了新的前景，因为它们易于获取、作为仿制药成本低廉，并且在人类中长期安全使用。
This review highlights the outcomes of preclinical and clinical studies of these drugs as a potent anticancer agent(s) conducted in the last two decades.
本综述重点介绍了过去二十年对这些药物作为强效抗癌剂进行的临床前和临床研究的结果。
Substantial preclinical studies, as well as limited clinical trials, suggest noteworthy anticancer potency of these pleiotropic benzimidazoles, particularly as potent microtubule disrupting, anti-angiogenic, and anti-metastatic agents, inhibitors of the immune checkpoint, hypoxia-inducible factor, epithelial-mesenchymal transition, cancer stemness, and multidrug resistance protein 1, and inducers of apoptosis and M1 polarization.
大量的临床前研究以及有限的临床试验表明这些多效性苯并咪唑具有显著的抗癌效力，特别是作为强效的微管破坏剂、抗血管生成剂和抗转移剂、免疫检查点抑制剂、缺氧诱导因子抑制剂、上皮-间质转化抑制剂、癌症干性和多药耐药蛋白 1 抑制剂，以及细胞凋亡和 M1 极化的诱导剂。
These anticancer effects are attributed to multiple action points, including intrinsic apoptosis, canonical Wnt/β-catenin, JAK/STAT-3, JNK, MEK/ERK, and hedgehog signaling pathways.
这些抗癌作用归因于多个作用点，包括内在凋亡、经典 Wnt/β-catenin、JAK/STAT-3、JNK、MEK/ERK 和 hedgehog 信号通路。
The effective anticancer properties of mebendazole, albendazole, and flubendazole either alone or synergistically with frontline drugs, warrant their validation through controlled clinical trials to use them as promising avenues to anticancer therapy.
甲苯达唑、阿苯达唑和氟苯达唑单独使用或与一线药物协同使用时均具有有效的抗癌特性，值得通过对照临床试验进行验证，以将其作为有希望的抗癌治疗途径。
Disclaimer: 免责声明：
This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only.
本网站并非旨在向您或任何其他个人提供医疗建议、专业诊断、意见、治疗或服务。我通过本网站及其链接提供的信息仅供教育用途。
The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider.
本网站提供的信息或通过其他网站链接提供的信息不能替代医疗或专业护理，您不应使用这些信息代替就诊、电话咨询或您的医生或其他医疗保健提供者的建议。
I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.
我对您在本网站获得的任何建议、疗程、诊断或任何其他信息、服务或产品均不承担任何责任。以上内容仅代表我个人对我们在这条路上所学知识的看法。
Please read an extended version of the Disclaimer here: https://www.cancertreatmentsresearch.com/?page_id=1794
请在此处阅读免责声明的扩展版本： https://www.cancertreatmentsresearch.com/? page_id=1794
Thank you Dear Daniel for all the priceless articles and information but also support you’ve so generously dispensed to us and the public.
亲爱的丹尼尔，感谢您提供的所有宝贵的文章和信息，也感谢您慷慨地为我们和公众提供的支持。
May you have all the good health in the world to help you achieve your goals in life.
祝您身体健康，助您实现人生目标。
Warm Regards, 温暖的问候，
Alex 亚历克斯
Thank you Alex! 谢谢你，亚历克斯！
However, instead of keeping for myself, I would like to pass all that to your mom and all those who are in very much need for good health. I hope this type of information will help on that line as well.
然而，我不想独享这一切，而是想把这些分享给你妈妈，以及所有那些亟需健康的人。希望这些信息也能在这方面有所帮助。
Also, you were ultrafast with posting a comment here, as I just published the post 🙂
另外，你在这里发表评论的速度非常快，因为我刚刚发布了帖子 🙂
Kind regards, 亲切的问候，
Daniel 丹尼尔
You are most generous, words can not describe our feelings,
您太慷慨了，言语无法形容我们的感受，
as for my speed, i can be much faster when i am focused, much, much faster.https://www.youtube.com/watch?v=12u1nA7bXzc
至于我的速度，当我集中注意力时，我可以更快，快得多。https://www.youtube.com/watch?v=12u1nA7bXzc
Cheers 干杯
Dear Daniel, 亲爱的丹尼尔，
With regard to speed i write to you.
关于速度，我写信给你。
The link to the table https://1drv.ms/x/s!AgyLnvi3scoTojUrZihYZ4-NM1Ke
表格链接： https://1drv.ms/x/s!AgyLnvi3scoTojUrZihYZ4-NM1Ke
Between 18-feb and 6-march we only used aspirin and cbd oil
2 月 18 日至 3 月 6 日期间，我们只使用了阿司匹林和 CBD 油
The rest is familiar, ALA, HCA, DCA, CA, Resveratrol, Cabbage Brine, Silimarin, etc…………..
其余的都是我们熟悉的，ALA、HCA、DCA、CA、白藜芦醇、卷心菜盐水、水飞蓟素等…………..
Funny thing is when we used only those 2, we got apparently slower growth than we are getting now.
有趣的是，当我们只使用这两者时，我们的增长速度显然比现在慢。
I remember one of Ergin’s reply about HCA potentially boosting cancer, i wonder and ponder.
我记得 Ergin 的一条回复说 HCA 可能会促进癌症，我很好奇并思考。
Are you pondering what i am pondering?
您是否在思考我正在思考的事情？
It may prove crucial for so many to determine if HCA is to be “blamed” since in theory, all the others would have blasted cancer hard, in theory, at least hold it in place and not allowing it to grow.
对于很多人来说，确定 HCA 是否应该“受到指责”可能至关重要，因为从理论上讲，所有其他癌症都会对癌症造成严重破坏，至少在理论上将其控制在原位，不让其生长。
So here i am a bit more “focused”.
所以在这里我更加“专注”了。
Many many Thanks, 非常感谢，
Alex 亚历克斯
Dear Alex, 亲爱的亚历克斯，
So far, all the science I came across indicates the anti cancer potential of HCA and not the other way around. As a result, I do not resonate with your thoughts. If you find literature to support that I would be please to closely study that.
到目前为止，我所接触到的所有科学研究都表明 HCA 具有抗癌潜力，而不是 HCA 具有抗癌潜力。因此，我并不认同你的想法。如果你能找到相关文献支持这一点，我很乐意仔细研究一下。
You could start your research by using this keywords in Google search “hydroxycitrate cancer growth”.
您可以在 Google 中使用此关键词搜索“羟基柠檬酸癌症生长”来开始您的研究。
It is easy for us to make misleading connections. To makes sure we made the right connections, we should constantly zoom in and zoom out.
我们很容易做出误导性的联想。为了确保我们做出正确的联想，我们应该不断地放大和缩小。
Regarding your observation, i.e. tumor markers were growing slower at beginning compared to now could be due to at least 3 major reasons:
关于您的观察，即肿瘤标志物一开始比现在增长得更慢，可能至少有 3 个主要原因：
– it is well known that tumors have an exponential growth – so it is possible that nothing of what you did actually seriously affected the normal trend of the tumor growth
众所周知，肿瘤呈指数级增长，因此，你所做的一切可能并没有严重影响肿瘤生长的正常趋势
– it is possible that while using high dose Aspirin you succeeded to dampen the tumor growth more than you did latter when you lowered the dose.
– 有可能，在使用高剂量阿司匹林时，您比降低剂量时更能抑制肿瘤的生长。
However, that treatment was not sustainable since if you would continue with the oral dose you used at beginning you could also kill you dear mom not only the tumor due to the side effects that come with long term use of very high dose Aspirin.
然而，这种治疗是不可持续的，因为如果您继续一开始使用的口服剂量，您不仅会杀死肿瘤，还会因长期使用大剂量阿司匹林带来的副作用而杀死您亲爱的妈妈。
– it could also be that CA fueled the tumor growth
– 也可能是 CA 促进了肿瘤的生长
Time will tell which of the above is true.
时间将证明上述哪种说法是正确的。
In conclusion, there is no way in my mind to connect HCA with tumor growth.
总之，我认为 HCA 与肿瘤生长没有关系。
I would also like to kindly ask you and all, if we could address the questions in the right post so that when we look back for something we can find it in the right place. Thus, HCA question could be addressed in the anti cholesterol strategy post or the post on ACLY inhibition.
我还想请教大家，我们能否在正确的帖子里解答这些问题，这样我们回头查找的时候就能在正确的地方找到。因此，HCA 的问题可以在抗胆固醇策略帖子或 ACLY 抑制帖子里讨论。
Thanks in advance for considering this aspect in the future.
在此先感谢您将来考虑这方面的问题。
Kind regards, 亲切的问候，
Daniel 丹尼尔
Hello Alex I think I you would be interested in my story about mebendazole and cimitidine tablets curing me of cancer .I got the information about them from the same you have mentioned http://www.abovetopsecret.com I wrote about it about it on the same site and I also filmed the doctor when I explained to him about the drugs after he told me my cancer has gone .. Please take a read http://www.abovetopsecret.com/forum/thread990234/pg1. Thanks
你好，亚历克斯，我想你会对我的故事感兴趣，关于甲苯咪唑和西咪替丁片治愈癌症的故事。我是从你提到的那个网站 http://www.abovetopsecret.com 上找到这些信息的，我也在同一个网站上写过相关文章，而且我还拍了医生告诉我癌症已经痊愈后，我向他解释这些药物的场景。请你去看看 http://www.abovetopsecret.com/forum/thread990234/pg1 。谢谢。
Any one taking Albendazol? Would be great to know a protocol or similar to avoid side effects
有人在服用阿苯达唑吗？如果知道一些避免副作用的方案或类似方法就好了。
I do know someone using for long time Albendazole but he was using a lot of supportive supplements for the liver as well.
我确实知道有人长期使用阿苯达唑，但他也使用了很多肝脏支持补充剂。
In a clinical trial, Albendazole was given orally on a day 1–14 of a 3 weekly cycle, starting at 400 mg BD with dose escalation until 1,200 mg BD.
在一项临床试验中，阿苯达唑在 3 周为一个周期的第 1-14 天口服，从 400 毫克 BD 开始，剂量逐渐增加至 1,200 毫克 BD。
Result of the trial: The maximum tolerated dose was 2,400 mg per day (1,200 BD). Myelosuppression was the main dose limiting toxicity. Fatigue and mild gastrointestinal upset were the other major adverse effects.
试验结果：最大耐受剂量为每日 2,400 毫克（1,200 BD）。骨髓抑制是主要的剂量限制性毒性。其他主要不良反应包括疲劳和轻度胃肠不适。
4 out of 24 assessable patients (16%) had a tumor marker response with a fall of at least 50% from baseline values and another patient had a prolonged period of stable marker response. A decline in plasma vascular endothelial growth factor levels was observed.
24例可评估患者中，4例（16%）肿瘤标志物反应较基线值下降至少50%，另有1例患者标志物反应维持时间较长且稳定。患者血浆血管内皮生长因子水平下降。
Conclusions of the trial: Albendazole was well tolerated on the schedule tested in this trial. The results of this study suggest that the recommended dose for further study is 1,200 mg twice daily for 14 days in a 21-day cycle.
试验结论：在本试验的给药方案下，阿苯达唑耐受性良好。研究结果表明，进一步研究的推荐剂量为每次1200毫克，每日两次，共14天，每21天为一个疗程。
Supporting the liver: e.g. silymarin, hepamertz, astragalus, alpha lipoic acid
支持肝脏：例如水飞蓟素、肝素、黄芪、α-硫辛酸
I always get excited when i receive a notification saying you posted a new article. Thanks again for an excellent summary! It might be interesting to know that the Care Oncology Clinic cycles MBZ with Doxycycline. One month on, one month off
每次收到你发新文章的通知，我都会很兴奋。再次感谢你精彩的总结！或许你对 Care Oncology Clinic 的 MBZ 和强力霉素循环疗法感兴趣。一个月用药，一个月停药。
Regards, 问候，
Carl 卡尔
Thank you, Carl! That is interesting indeed. When I find the time, I will get in contact with them.
谢谢你，卡尔！这确实很有趣。等我有时间了，我会联系他们。
Kind regards, 亲切的问候，
daniel 丹尼尔
And to me it seems that mebendazole does not have as brutal side effects as chloroquine for instance ( retinopathy, nerve damage etc)
在我看来，甲苯咪唑似乎没有像氯喹那样严重的副作用（视网膜病变、神经损伤等）
That is also my perception W.
这也是我的看法 W。
and for anyone interested, the thailand source daniel proposed above is very reliable and very responsive, highly recommended.
对于任何感兴趣的人来说，上面丹尼尔推荐的泰国来源非常可靠，反应非常灵敏，强烈推荐。
Nice to hear that W. I also had a good feeling about them when I ordered something, sometime ago.
很高兴听到 W 这么说。不久前我订购东西时也对他们有很好的感觉。
Kind regards, 亲切的问候，
Daniel 丹尼尔
Dear Daniel, 亲爱的丹尼尔，
Thank you for this new post.I like mebendazole too much.
谢谢你的这篇新帖子。我太喜欢甲苯咪唑了。
It is in my top 3 drug list.I have seen good responces after taking mebendazole.
它是我的前 3 种药物之一。服用甲苯咪唑后我看到了良好的反应。
As far as i know,alternmed was using Albendazole for his dear mom.
据我所知，alternmed 正在为他的亲爱的妈妈使用阿苯达唑。
Kind Regards 亲切的问候
Ergin 成人
Thank you Ergin. Can you share your top 3 drug list with us?
谢谢你，Ergin。你能和我们分享一下你最喜欢的三种药物清单吗？
Kind regards, 亲切的问候，
Daniel 丹尼尔
Hi Daniel, 嗨，丹尼尔，
1-Why mebendazole?Bowel obstruction released,it is a perfect happening for us these days.
1-为什么是甲苯咪唑？肠梗阻解除了，这对我们来说是一件完美的事情。
2-Phlorizin,as you know i am in love with it and i will use it as a golden shot with hyperthermia.
2-Phlorizin，如你所知，我很喜欢它，我会用它作为高温治疗的黄金良药。
3-Lonidamine.(It is working synergetic with Phlorizin)
3-氯尼达明。（与根皮苷有协同作用）
There is a comparison with 3BP and Lonidamine below but i dont understand too much.Which one is better?
下面是 3BP 和 Lonidamine 的比较，但我不太明白。哪一个更好？
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585687/
Kind Regards 亲切的问候
Ergin 成人
Thanks. For keeping gastro intestinal path safe I would also consider on of the best https://www.cancertreatmentsresearch.com/pyrvinium-pamoate/ just gastro intestinal because it cannot be absorbed beyond.
谢谢。为了保证胃肠道安全，我也会考虑最好的药物之一 https://www.cancertreatmentsresearch.com/pyrvinium-pamoate/ 只用于胃肠道，因为它无法被肠道吸收。
Answer to the question: 3BP
问题答案：3BP
Thank you very much Daniel.I have to work on PP too much.
非常感谢 Daniel。我必须在 PP 上投入太多精力。
Because if you have a bowl problem,you can’t do any treatments nor eating.
因为如果您有碗问题，您就无法进行任何治疗，也无法进食。
Great Help 很大的帮助
Indeed, that is why we use it in cycles to prevent them.
确实，这就是我们循环使用它来预防它们的原因。
Both the Kruidvat drug store chain as its twin compagny Trekpleister sell them at 2.59 euro (2.75 USD today) OTC in the Netherlands (I am Dutch). However they appear not to sell them online abroad.
Kruidvat 药店连锁店及其姊妹公司 Trekpleister 在荷兰以 2.59 欧元（相当于今天的 2.75 美元）的非处方药价格出售（我是荷兰人）。不过，国外似乎没有线上销售。
They are selling a generic copy of the originals, but besides color of the tablet, I havent noticed any difference (have used both in the past).
他们出售的是原版的通用副本，但除了平板电脑的颜色外，我没有注意到任何区别（过去都使用过）。
Thank you Vincent. I’ve seen them in Kruidvat indeed 🙂
谢谢 Vincent。我确实在 Kruidvat 见过他们🙂
As far as the Norwegian CRC patient with great initial response…in the end brain mets turned up. His doctor tried the MBZ approach in five other patients, with only one minor response as result.
就那位挪威的 CRC 患者而言，最初反应良好……但最终却出现了脑转移。他的医生在其他五位患者身上尝试了 MBZ 疗法，结果只有一位患者出现了轻微反应。
Indeed, there is a paragraph on that in the Anticance Fund article stating the following:
事实上，抗癌基金文章中有一段关于此内容的内容如下：
“A case of metastatic colon cancer treated with MBZ was described by Peter Nygren and Rolf Larsson in 2013 [24].
2013 年，Peter Nygren 和 Rolf Larsson 描述了一例用 MBZ 治疗转移性结肠癌的病例[24]。
Here, a 74-year-old patient suffering from progressive metastatic colon cancer had been treated first with capecitabine, oxaliplatin, and bevacizumab, and then by capecitabine and irinotecan in the face of disease progression, and who had no standard treatment options available was started on an oral dose of MBZ of 100 mg twice a day.
这里，一名 74 岁的患有进行性转移性结肠癌的患者首先接受卡培他滨、奥沙利铂和贝伐单抗治疗，然后面对病情进展接受卡培他滨和伊立替康治疗，并且由于没有可用的标准治疗选择，开始每天两次口服 100 毫克 MBZ。
MBZ was selected based on the author’s previous pre-clinical work with MBZ [20]. After six weeks of monotherapy, radiological evaluation showed near complete remission of metastatic lesions in the lungs and lymph nodes and a good partial remission in the liver.
选择 MBZ 是基于作者先前对 MBZ 的临床前研究[20]。单药治疗六周后，放射学评估显示肺和淋巴结转移性病变接近完全缓解，肝脏转移性病变获得良好的部分缓解。
However, the patient experienced elevated liver enzymes (AST and ALT), so MBZ was temporarily stopped and then started at half the dose, with the patient reporting no ill effects. Liver enzymes normalised and a subsequent round of CT scans confirmed the initial disease response.
然而，患者出现肝酶（AST 和 ALT）升高，因此暂时停用 MBZ，然后以一半的剂量重新开始使用，患者报告没有出现任何不良反应。肝酶恢复正常后，后续的 CT 扫描证实了最初的疾病反应。
After ceasing treatment for approximately three months, the patient developed brain metastases that were treated with radiotherapy, following by evidence of disease in the lymph nodes.
停止治疗约三个月后，患者出现脑转移，接受放射治疗，随后淋巴结出现疾病迹象。
MBZ treatment was not recommenced following the discovery of the brain metastases or in subsequent disease progression. A further five patients have been treated, with one experiencing a minor remission [Private communication from Peter Nygren].” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/
在发现脑转移或随后病情进展后，未重新开始接受 MBZ 治疗。另有五名患者接受了治疗，其中一名患者病情轻微缓解[Peter Nygren 的私人通信]。https ://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/
D, you have so many great suggestions on your site!
D，您的网站上有很多很棒的建议！
Love to hear your comments about dandelion root. This one sounded out there, though a phase 1 trial has been given the go ahead. In preclinical research single agent treatment resulted in tumor stasis.
很高兴听到你对蒲公英根的评论。这个听起来有点奇怪，虽然一期临床试验已经获批了。在临床前研究中，单药治疗导致肿瘤停滞。
Also love to hear what your opinion is of liposomal formulations. There is an evolving technology base that perhaps could be applied to a very wide range of treatments.
也想听听你对脂质体制剂的看法。脂质体制剂的技术基础正在不断发展，或许可以应用于各种各样的治疗。
Wonder whether liposomal vitamin C with a targeting mechanism could be added on top of IV vitamin C to push the tumor into a total ROS crisis.
想知道是否可以在静脉注射维生素 C 上添加具有靶向机制的脂质体维生素 C，以将肿瘤推入完全 ROS 危机。
Best Wishes 最好的祝愿
Hey J, 嘿，J，
Very nice to hear from you. I think dandelion root is indeed relevant, but in order to comment on that I will have to look in to it in details. I will do that asap. Also interesting to hear about phase 1. Regarding liposomal formulations, I was very excited some years ago.
很高兴收到你的来信。我认为蒲公英根确实与此相关，但为了对此发表评论，我必须对其进行详细研究。我会尽快去做。听到关于第一阶段的研究也很有意思。关于脂质体制剂，几年前我就非常兴奋。
I think we also discussed on Compass. Yet, I haven’t heard anyone reporting outstanding results after using them (Vitamin C, Resveratrol, etc.). Have you heard of any?
我记得我们在 Compass 上也讨论过。不过，我还没听说有人用过这些产品（维生素 C、白藜芦醇等等）后有显著效果。你听说过吗？
In theory I like the idea and I think I added a link on the Vitamin C post, to a website of a researcher who is expert in making the liposomal version.
理论上我喜欢这个想法，我想我在维生素 C 帖子上添加了一个链接，指向一位擅长制作脂质体版本的研究人员的网站。
Kind regards, 亲切的问候，
Daniel 丹尼尔
hi Jcancom, 你好，Jcancom，
never heard about dandelion root being potent. Its funny – i keep seeing this plant where i live, it seems to me very invasive. will check – and maybe dig deep :D:D:
我从来没听说过蒲公英根有这么强的药效。真有意思——我住的地方经常看到这种植物，感觉它入侵性很强。我会去查一下——或许还会深入研究一下 :D:D:
I’ve used Dandelion root tea for a few months. I don’t remember if there were great results or anything (I suspect not) but there were no side effects.
我喝了几个月的蒲公英根茶。我不记得效果怎么样（我怀疑没什么效果），但确实没有副作用。
Sorry here are some references about dandelion root.
抱歉，这里有一些关于蒲公英根的参考资料。
This one impressed me. PMID: 27564258
这张照片给我留下了深刻的印象。PMID：27564258
Report suggests anti-cancer effects in pancreatic, colorectal and other cancers.
报告表明其对胰腺癌、结肠直肠癌和其他癌症具有抗癌作用。
I found Figure 4B especially impressive: the tumor has essentially stopped growing.
我发现图 4B 特别令人印象深刻：肿瘤基本上已经停止生长。
Such a strong result for a single agent treatment is encouraging.
单一药物治疗取得如此强劲的效果令人鼓舞。
Here’s some more of the background.
以下是一些背景信息。
https://www.cancertutor.com/dandelionroot/
“The diuretic effects of dandelion can lead to increased excretion of certain medications. …
“蒲公英的利尿作用可以增加某些药物的排泄。......
Dandelion leaf contains coumarins, chemicals which increase the risk of bleeding.”
蒲公英叶含有香豆素，这种化学物质会增加出血的风险。”
Dangers of dandelion 蒲公英的危害
http://www.livestrong.com/article/210093-dangers-of-dandelion-tea/
Hi Daniel, I am not on mebendazole regularly (although I do sometimes have some.) However, looking at this wonderful information you have put up on this page, perhaps I should be taking albendazole for advanced ovarian cancer?
你好，丹尼尔，我并不经常服用甲苯咪唑（尽管有时我会服用一些）。但是，看了你在这个页面上提供的精彩信息，也许我应该服用阿苯达唑来治疗晚期卵巢癌？
I was taking cimetidine but I stopped after somebody told me it was an oestrogen driver.
我一直在服用西咪替丁，但当有人告诉我它是雌激素驱动剂后，我就停药了。
I am rattling with all the drugs and supplements I am taking. I don’t know if it is all these drugs, potions and tablets that is making me feel so bad every day, or if it is the cancer progressing.
我吃的那些药和补品让我烦躁不安。我不知道是这些药、药水和药片让我每天都感觉这么难受，还是癌症在不断恶化。
My CA125 is rising constantly, but it always has and I have managed long spells without treatment. How can I work out if it is all the drugs that are making me feel bad?
我的 CA125 一直在升高，而且它一直都在升高，而且我已经很长时间没有接受治疗了。我该如何判断是不是药物让我感觉不舒服？
I have reduced all the supplements I was on because I felt there were too many. I was taking over 100 tablets a day at one point which is just mad I think. Does anyone agree?
我减少了所有补充剂的用量，因为我觉得太多了。我一度一天要吃100多片，我觉得这简直太疯狂了。有人同意吗？
Hectoria, 赫克托莉亚，
how are you? 你好吗？
I agree its quite heavy to take so many pills and even tiring. I stop at around 40 which might also look crazy to many.
我同意吃这么多药确实很辛苦，甚至很累。我大概吃了40片就停药了，这在很多人看来可能也很疯狂。
Wow. Congratulations on your searching. You found very important informations. Did you used this combination Mebendazole+Doxicicline? Did it worked?
哇！恭喜你搜索成功！你找到了非常重要的信息。你用过甲苯咪唑+多西环素这个组合吗？有效吗？
Thx. 谢谢。
Hi Helene, 嗨，海伦，
Thank you. 谢谢。
It depends what you mean by working.
这取决于你所说的“工作”是什么意思。
My interpretation of a working treatment approach is that it will at least extend the life of the patient (while not reducing its quality). We did used Mebendazole and Doxi and we felt it helped a lot and had their own contribution to the extra years we’ve gained.
我对有效治疗方法的理解是，它至少能延长患者的寿命（同时不会降低其生活质量）。我们确实使用了甲苯咪唑和阿司匹林，感觉效果很好，也为我们延长的寿命做出了贡献。
Kind regards, 亲切的问候，
Daniel 丹尼尔
Excellent information. Will certainly try it in my practice.
非常好的信息。我一定会在实践中尝试一下。
Thank you for the feedback dr. Nuri. Please keep us up to date with the results, since this info will help many other people. Also, if you are aware of any other treatments with potential, we here are always glad to know them and research them.
感谢 Nuri 医生的反馈。请及时告知我们最新的结果，因为这些信息将帮助更多人。此外，如果您知道任何其他有潜力的治疗方法，我们也非常乐意了解并研究。
Kind regards, 亲切的问候，
Daniel 丹尼尔
It seems there is a rebound effect once the mebendazole is stopped, tge cancers seemed to come back. If I start taking it does that mean I will have to remain on it indefinitely?
停用甲苯咪唑似乎会出现反弹效应，癌症似乎又复发了。如果我开始服用它，是不是意味着我必须一直服用下去？
If I would use MBZ and see results I would indeed take it for long time. There are studies on people taking it for many years with no specific side effect.
如果我能用 MBZ 并且看到效果，我肯定会长期服用。有研究表明，服用多年后，患者并没有出现任何特定的副作用。
Boa noite ! 晚安 ！
Vocês já ouviram falar em Auto Hemo Terapia ?
您听说过自体血疗法吗？
Uma técnica usada aqui no Brasil principalmente para CA leucemia e usado junto com ascaridil,
巴西使用的一种技术主要用于治疗 CA 白血病，并与阿斯利地尔一起使用，
Google Translation: 谷歌翻译：
Good evening ! 晚上好 ！
Have you ever heard of Auto Hemo Therapy?
您听说过自体血疗法吗？
A technique used here in Brazil mainly for CA leukemia and used together with ascaridil,
巴西使用的一种技术主要用于治疗 CA 白血病，并与阿斯利地尔一起使用，
Hi Aline, 嗨，Aline，
Yes, I heard of autohemotherapy. I have no scientific background on that line yet. I find it interesting as a concept and since there are no special side effects I would try it.
是的，我听说过自体血疗法。我对此还没有科学背景。我觉得它的概念很有趣，而且由于没有特殊的副作用，所以我会尝试一下。
But I would not completely rely on that as single treatment strategy – instead, I would make sure I use other treatments in parallel.
但我不会完全依赖它作为单一的治疗策略——相反，我会确保同时使用其他治疗方法。
Kind regards, 亲切的问候，
Daniel 丹尼尔
Hello Daniel, 你好，丹尼尔，
first, thank you for all the work you are doing!
首先，感谢您所做的一切工作！
Than, eventhough I have not been diagnosed yet I do have very same sympthoms of pancreatic cancer for couple of months.
然后，尽管我还没有被诊断出来，但几个月来我确实出现了胰腺癌的症状。
All my blood results are pretty normal except a higher bilirubin (but I do have Gilbert syndrome so hard to say :-/ ) and IGG4 which is a bit higher 1.7g/L, CEA 2.7 and CA19-9 about 17 kU/l (both within a normal range, but this does not mean much sometimes).
我的所有血液检查结果都很正常，除了胆红素较高（但我确实患有吉尔伯特综合症，所以很难说:-/）和 IGG4 稍高 1.7g/L，CEA 2.7 和 CA19-9 约 17 kU/l（均在正常范围内，但有时这并不意味着什么）。
I have been reading about autoimunne pancreatitis, but they tend to have much higher serum IGG4 anyway. There is about 10 percent PC pacients with higher IGG4 serum levels (exactly at the same levels as mine).
我一直在阅读关于自身免疫性胰腺炎的文章，但这类患者的血清 IGG4 水平通常要高得多。大约有 10%的胰腺癌患者血清 IGG4 水平较高（与我的水平完全相同）。
Abdominal ultrasound is showing nothing for few times and endoscopic ultrasound (EUS) could not be made because the probe was blocked inside my throat so the operator could not get in for safety reasons.
腹部超声检查几次都没有显示任何结果，并且无法进行内镜超声检查 (EUS)，因为探头堵在我的喉咙里，操作员出于安全原因无法进入。
I have done MRI without contrast (+MRCP) /, showed only mild narrowing in left hepatic duct. I have lost several kg during few months and instead of waiting I have been proactive and googled a curcumin and other stuff I have been taking during that time.
我做过无造影 MRI（+MRCP），结果显示左肝管仅轻微狭窄。几个月来我瘦了几公斤，我没有等待，而是积极主动地在谷歌上搜索了姜黄素和其他我这段时间一直在服用的药物。
Until I have found your site and started to be more systematic, therefore I m running on Metabloc (ALA+HCA) + quercetin+EGCG before meal and resveratrol + tocotrienols + boswellia extract after the meal. I´do also have Omeprazol 2 times per day.
在我找到您的网站并开始更加系统化地服用之前，我餐前服用 Metabloc (ALA+HCA) + 槲皮素 + EGCG，餐后服用白藜芦醇 + 生育三烯酚 + 乳香提取物。我每天还会服用两次奥美拉唑。
I would like to start using the Mebendazole but I have not found any info concerning other protocols that could be used along with the Mebendazole. I would like to keep it as simple as possible with only those items that will actually work together.
我想开始使用甲苯咪唑，但我没有找到任何关于可以与甲苯咪唑一起使用的其他方案的信息。我希望尽可能简化流程，只使用那些真正能协同作用的药物。
Or is there any protocol / substance which is not recommened to take during the Mebendazole treatment?
或者在甲苯咪唑治疗期间是否有任何不建议采取的方案/物质？
Sorry for such a long comment :-/
抱歉评论这么长:-/
T.
Hi T, 打，
You are very welcome. Loosing kg as a result of cancer would usually happen when cachexia is present and is correlated with a large amount of tumour cells which is not the case here. So let’s hope and expect there is no cancer.
不用客气。癌症导致体重下降通常发生在恶病质患者身上，并且与大量肿瘤细胞有关，但本例并非如此。所以，让我们祈祷并期待没有癌症吧。
Mebendazole and Omeprazole are over the counter drugs so anyone could try them anyway. At this point, I would not go for Albendazole (you mentioned that in the other comment) or similar due to the high toxicity at the liver. The other supplements sound good.
甲苯咪唑和奥美拉唑都是非处方药，所以任何人都可以尝试。目前，我不会选择阿苯达唑（你在另一条评论中提到过）或类似药物，因为它们对肝脏毒性很大。其他补充剂听起来不错。
Other supplements and drugs that may be relevant are mentioned here https://www.cancertreatmentsresearch.com/cancer-treatments/ In general, I would have a preventive focus in your case, and when we speak about prevention on major point we should think of addressing is Inflammation.
这里提到了其他可能相关的补充剂和药物 https://www.cancertreatmentsresearch.com/cancer-treatments/ 总的来说，我会以预防为重点，当我们谈到预防时，我们应该考虑解决的主要问题是炎症。
Life style (including diet and exercise) would be the base to address inflammation, and next to that we can add drugs such as Low Dose Aspirin (100mg/day) and supplements such as Omega 3 and Curcumin.
生活方式（包括饮食和运动）是解决炎症的基础，此外，我们还可以添加药物，例如低剂量阿司匹林（100 毫克/天）和补充剂，例如 Omega 3 和姜黄素。
Addressing the immune system with supplements such as those mentioned at the link above (e.g. Coriolus), as well as using probiotics (fermented foods) should also help on this line. A little similar discussion we had here https://www.cancertreatmentsresearch.com/community/forum-to-discuss-treatment-protocols-and-drugsupplement-cocktail/reducing-supplement-protocol-berberine-metatrol-alamax/#post-828
使用上面链接中提到的补充剂（例如云芝）以及益生菌（发酵食品）来增强免疫系统，也应该会有所帮助。我们之前也讨论过类似的问题，网址 ：https://www.cancertreatmentsresearch.com/community/forum-to-discuss-treatment-protocols-and-drugsupplement-cocktail/reducing-supplement-protocol-berberine-metatrol-alamax/#post-828
Answering your question: I am not aware of any drugs that should not be combined with Mebendazole but you can always check interactions here https://reference.medscape.com/drug-interactionchecker?src=google
回答您的问题：我不知道有哪些药物不能与甲苯咪唑结合使用，但您可以随时在这里查看相互作用 https://reference.medscape.com/drug-interactionchecker?src=google
Thank you for pointing out Essential Forte.
感谢您指出 Essential Forte。
Kind regards, 亲切的问候，
Daniel 丹尼尔
Atom, I really like this one for pancreatic diagnosis. Of course, one would not to rely on it by itself, though it can give up to 3 years ( perhaps even 4 years!!) early warning before symptoms even emerge.
Atom，我非常喜欢这个用于胰腺诊断的工具。当然，人们不会完全依赖它，尽管它可以在症状出现前提供长达 3 年（甚至 4 年！！）的预警。
It is very difficult for me to understand why this has not been applied to the clinic already. Waiting until frank pancreatic cancer symptoms develops until a diagnosis is made can hardly be regarded as ethically acceptable.
我很难理解为什么这种做法至今仍未在临床上得到应用。等到胰腺癌出现明显症状才进行诊断，这在伦理上很难被接受。
The figure from the article shows clear hyperglycemia with a quadratically increasing fasting glucose level 3 years before typical diagnosis. It is startling! Pancreatic cancer appears to generate a large amount of glucose. Does any other cancer do this?
文章中的图表显示，在典型诊断前3年，患者出现了明显的高血糖症，空腹血糖水平呈二次方增长。这太令人震惊了！胰腺癌似乎会产生大量的葡萄糖。其他癌症也会出现这种情况吗？
This is an entirely novel manifestation of the metabolic perspective of cancer.
这是癌症代谢视角的全新体现。
It is not clear to me yet how this information will be used by clinicians. They might want to confirm this with a dose of 3-BP. If the glucose levels were knocked down, then they might conclude that pancreatic caner was present.
我目前还不清楚临床医生会如何使用这些信息。他们可能想用一剂 3-BP 来确认一下。如果血糖水平降低，他们可能会得出胰腺癌的结论。
Alternatively, with further imaging etc. it might thought best to move to surgery right from there. 3 years ahead of symptoms might be ahead of metastatic spread.
或者，通过进一步的成像等，可能认为最好从那时起就进行手术。出现症状前 3 年可能就是转移扩散前。
https://www.ncbi.nlm.nih.gov/pubmed/?term=29723506
thanks Jcancom, I will definitely monitor my glucose level as it´s already on the low prediabetes side (5.7 mmol/l) but the value remains pretty stable for few months and I do not actually know the value prior the symphtoms. I have just found an article about Fenbendazol – it´s easier to find locally, so I will go probably that way.
谢谢 Jcancom，我一定会监测我的血糖水平，因为它已经处于糖尿病前期的低水平（5.7 mmol/l），但几个月来血糖值一直很稳定，而且我实际上并不知道症状出现之前的血糖值。我刚刚找到一篇关于芬苯达唑的文章——在当地更容易找到，所以我可能会去那里看看。
..and when talking about Albendazole and liver support. One would try Essential Forte as it´s widely used in bodybuilders comunity when/after they stop with steroid course to quickly detox they liver so they can start with the next steroid course as soon as possible.
……说到阿苯达唑和肝脏支持，有人会推荐尝试 Essential Forte，因为它在健美运动员群体中被广泛使用，在他们停止类固醇疗程后，可以快速排毒肝脏，以便尽快开始下一个类固醇疗程。
Recent (since 2018) patent pending application on Mebendazole to be used as a cancer therapy:
最近（自 2018 年起）正在申请将甲苯咪唑用作癌症治疗的专利：
“Mebendazole cancer therapies and methods of use”
“甲苯咪唑癌症疗法和使用方法”
https://patents.google.com/patent/US20190175560A1/en
This was done by SHEPHERD Therapeutics, http://shepherd.bio/our-story/the-idea/, a company claiming to do it’s best for cancer patients. Yet, I find it unfair to take common knowledge and try to make money out of that, while possibly restricting it’s application in oncology as a cheap repurpused drug.
这是 SHEPHERD Therapeutics 公司（ http://shepherd.bio/our-story/the-idea/ ）做的，这家公司声称要为癌症患者竭尽全力。然而，我认为利用常识来赚钱是不公平的，因为这可能会限制其作为一种廉价的再利用药物在肿瘤学中的应用。
At least, more and more of our society is recognizing its potential.
至少，我们社会越来越多的人认识到它的潜力。
@Daniel: I think it would be fair to first ask them, if they plan to litigate, against those who allegedly would infringe on their Mebendazole related patent.
@Daniel：我认为首先询问他们是公平的，如果他们计划对那些涉嫌侵犯其甲苯咪唑相关专利的人提起诉讼。
They may be after money, or they may just try to establish a clear “prior art” case (patent priority date); actually, I would recommend that you do patent treatments endorsed by your Foundation (and license them freely, requiring just some registration), just to clearly establish the “prior art”.
他们可能是为了钱，也可能只是想建立一个明确的“现有技术”案例（专利优先权日）；实际上，我建议你采用基金会认可的专利治疗方法（并免费授权，只需要进行一些注册），只是为了清楚地建立“现有技术”。
Otherwise some drug companies could patent anti-cancer combos that have been proven to work, and then ask for money, from people or clinics using the combos.
否则，一些制药公司可能会对已被证明有效的抗癌组合申请专利，然后向使用这些组合的个人或诊所索要金钱。
Fair point Ovidiu. It would be interesting to know the answer if anyone can contact them.
Ovidiu 说得对。如果有人能联系到他们，知道答案会很有趣。
It just didn’t sounded right to me given that they are not the inventors. I am even wondering how it was possible to have the application even considered, given all the scientific articles already made public in the years prior to the application.
我觉得这听起来不对劲，因为他们不是发明人。我甚至怀疑，考虑到申请前几年已经发表的所有科学论文，这项申请怎么可能被考虑。
@Daniel: I browsed their patent (it’s a lot of Legalese, covering exhaustive applications), and to me it looks like they patented Mebendazole as a chemosensitizer, in various formulations, acting against common and rare cancers.
@Daniel：我浏览了他们的专利（其中有很多法律术语，涵盖了详尽的应用），在我看来，他们似乎将甲苯咪唑作为化学增敏剂申请了专利，以各种配方对抗常见和罕见的癌症。
Many of their claims were cancelled, and I wonder if it was because of prior art in the public domain, or in other patents…
他们的许多权利要求都被取消了，我想知道这是否是因为公共领域的现有技术，还是其他专利……
It is common to see patents covering other peoples’ genuine innovations, unfortunately.
不幸的是，专利涵盖其他人的真正创新的情况很常见。
Hopefully if Shepherd will defend their Mebendazole patent, they won’t do it in East Texas…
希望如果 Shepherd 愿意捍卫他们的甲苯咪唑专利，他们就不会在东德克萨斯州这么做……
Thank you Ovidiu. Indeed many of the claims were cancelled.
谢谢 Ovidiu。确实有很多索赔被取消了。
I was watching a recent talk(about a month ago) given by Dr. Burton Berkson (easily found in YouTube) where he says he has already been using Mebendazole as a Cancer treatment combined with Cimetidine, ALA, HCA, LDN
我最近（大约一个月前）看了伯顿·伯克森博士的一次演讲（在 YouTube 上很容易找到），他在演讲中说他已经将甲苯咪唑与西咪替丁、ALA、HCA、LDN 结合使用，作为癌症治疗药物。
Thanks for the heads up on that. I like all of them.
谢谢你提醒我。我都喜欢。
Dear Daniel, 亲爱的丹尼尔，
From what we understand, having reasonable blood counts is a must during chemotherapy treatment, allowing further chemotherapy treatment cycles.
据我们了解，化疗期间必须保持合理的血细胞计数，以便进行进一步的化疗治疗周期。
With relation to the above, we would appreciate your opinion regarding some warnings in the product monograph of mebendazole (https://www.janssen.com/canada/sites/www_janssen_com_canada/files/prod_files/live/vermox_cpm.pdf) and especially about reported cases of neutropenia and agranulocytosis:
鉴于上述情况，我们希望您能就甲苯咪唑产品专论中的一些警告（ https://www.janssen.com/canada/sites/www_janssen_com_canada/files/prod_files/live/vermox_cpm.pdf ）提出意见，特别是关于中性粒细胞减少症和粒细胞缺乏症的报告病例：
“…There have been reports of reversible liver function disturbances, hepatitis, and neutropenia described in patients who were treated with mebendazole at standard dosages for indicated conditions.
“…有报道称，接受标准剂量甲苯咪唑治疗的患者出现了可逆性肝功能紊乱、肝炎和中性粒细胞减少症。
These events, along with glomerulonephritis and agranulocytosis, have also been reported with dosages substantially above those recommended and with treatment for prolonged periods of time…”
据报道，这些事件以及肾小球肾炎和粒细胞缺乏症也与剂量大大高于推荐剂量以及长期治疗有关...”
We understand that quite many patients are applying some “cocktail” protocol to enhance their recovery chances and many of these protocols include mebendazole, but is it less recommended/ not recommended during the period of chemotherapy treatment, for the above concerns?
我们了解到很多患者正在采用某种“鸡尾酒”疗法来提高康复机会，其中许多疗法都包括甲苯咪唑，但出于上述考虑，在化疗期间是否不太推荐/不推荐使用甲苯咪唑？
Many thanks for your ongoing important help for the patients and their families!
非常感谢您一直以来为患者及其家属提供的重要帮助！
Best regards, Nissim 谨致问候，尼西姆
Dear Nisim, 亲爱的尼西姆，
In my view Mebendazole is a safe drug. Safe enough to be an over the counter drug. That is ofcourse a general statement.
我认为甲苯咪唑是一种安全的药物，安全到可以作为非处方药。当然，这只是一个概括性的说法。
Specifically, every person is different and there will be always some cases of people having undesired reactions to some drugs even if they are safe for most of the people.
具体来说，每个人都是不同的，即使某些药物对大多数人来说是安全的，也总会有一些人对某些药物产生不良反应。
So what I would do is to introduce it between a cyle of chemo at a low dose (i.e. 100mg/day) and see if there is any specific reaction. Btw, have you seen the discussion with Manuel on this forum. He is managing his mom’s brain cancer with a combo of drugs and supplements https://www.cancertreatmentsresearch.com/community/metabolic-inhibitors/combo-metformin-and-syrosingopine-looks-awesome/paged/2/#post-993 (if I remember correctly you are looking for treatment options for brain cancer)
所以我的做法是在低剂量（例如每天 100 毫克）的化疗周期之间引入它，看看是否有任何特定的反应。顺便问一下，你看过 Manuel 在这个论坛上的讨论吗？他正在用药物和补充剂的组合来治疗他妈妈的脑癌 https://www.cancertreatmentsresearch.com/community/metabolic-inhibitors/combo-metformin-and-syrosingopine-looks-awesome/paged/2/#post-993 （如果我没记错的话，你正在寻找脑癌的治疗方案）
Kind regards, 亲切的问候，
Daniel 丹尼尔
Dear Daniel, 亲爱的丹尼尔，
Many thanks for the answer and the additional reference!
非常感谢您的回答和补充参考！
Yes, you remember just right 🙂
是的，你记得很清楚 🙂
My question is related to my brother, 45 years old, with GBM grade IV (right temporal, since 3/2019).
我的问题与我哥哥有关，他 45 岁，患有 GBM IV 级（右颞叶，自 2019 年 3 月起）。
So far he got SOC therapy including:
到目前为止，他接受的 SOC 治疗包括：
* Tumor resection (quite good with no damages)
* 肿瘤切除术（效果较好，无损伤）
* Radiotherapy (30*2 gy)+ TMZ (75mg/day)
* 放射治疗 (30*2 gy) + TMZ (75mg/天)
* 2 (of 6) additional adjuvant TMZ cycles (150 mg/day * 5 days / every 4 weeks).
* 2 个（共 6 个）额外辅助 TMZ 周期（150 毫克/天 * 5 天/每 4 周）。
* Due to his having methylated MGMT, and based on a few clinical trials from Germany+US that we saw, we requested and he was approved by his physician to start this 3rd cycle an optional chemotherapy including: [CCNU (Lomustine 100 mg * 1day) + TMZ (100 mg/day * 5 days)] / every 6 weeks.
* 由于他的 MGMT 甲基化，并且基于我们看到的来自德国和美国的一些临床试验，我们提出请求并且得到了他的医生的批准，开始第 3 个周期的可选化疗，包括：[CCNU（洛莫司汀 100 毫克 * 1 天）+ TMZ（100 毫克/天 * 5 天）] / 每 6 周一次。
Remark – as in the clinical trials, in the next remaining 3 cycles TMZ might be updated up to 200 mg/day based on the blood counts results.
备注 - 与临床试验一样，在接下来的剩余 3 个周期中，TMZ 可能会根据血细胞计数结果更新至 200 毫克/天。
His blood counts were quite good after each chemotherapy cycle with TMZ and we hope to see this also with the updated, more aggressive, CCNU+TMZ therapy,
每次接受 TMZ 化疗后，他的血细胞计数都很好，我们希望在接受更新、更具侵略性的 CCNU+TMZ 疗法后也能看到同样的效果。
This is why we raised the question about the Mebendazole warnings regarding blood counts…
这就是我们提出有关甲苯咪唑与血细胞计数警告问题的原因……
I believe we’ll wait for the next blood count with the updated chemotherapy and try to introduce the Mebendazole as you suggested.
我相信我们会等待下一次血细胞计数和更新的化疗结果，并尝试按照您的建议引入甲苯咪唑。
Any comment/ suggestion will be appreciated!
任何评论/建议都将受到赞赏！
Beast regards, 野兽问候，
Nissim 雨
Hi Nissim, 你好，Nissim，
My father-in-law is a GBM IV survivor, almost 17 years, he was 52 when diagnosed. He received surgery, radiation followed by TMZ. He had a recurrence during TMZ and then got CCNU+Tamoxifen(40mg). To date, he’s on a maintenance dose of Tamoxifen(20mg).
我的岳父是胶质母细胞瘤 IV 期（GBM IV）的幸存者，已经活了将近 17 年，确诊时 52 岁。他接受了手术、放疗，然后服用替莫昔芬（TMZ）。在服用替莫昔芬期间复发，之后他接受了 CCNU+他莫昔芬（40 毫克）的治疗。目前为止，他仍在服用维持剂量的他莫昔芬（20 毫克）。
While he was on CCNU and Tamoxifen he also took 15mg of Melatonin. In addition, he took a supplement which isn’t available any longer but Sodium phenylbutyrate is a good substitute for what he took (antineoplastons A10).
在服用 CCNU 和他莫昔芬期间，他还服用了 15 毫克褪黑素。此外，他还服用了一种现在已经买不到的补充剂，但苯丁酸钠（抗瘤酮 A10）可以很好地替代他服用的药物。
Hope this helps, 希望这有帮助，
Johan 约翰
Hi Johan, 你好，Johan，
Many thanks for this enriching information, it sure help and encourage us!
非常感谢这些丰富的信息，它确实帮助和鼓励了我们！
I don’t know which pathological and genomic tests were common 17 years ago, but do you have any idea about it with regard to your father in law?
我不知道 17 年前哪些病理和基因组测试很常见，但您对您岳父的情况有什么了解吗？
Many thanks and we’ll investigate it further!
非常感谢，我们会进一步调查！
Best wishes, 最好的祝愿，
Nissim 雨
Hi Nissim, they didn’t do genomic testing, it’s been a long time ago indeed.
你好，Nissim，他们没有做过基因组测试，这确实是很久以前的事了。
All the best 一切顺利
Johan 约翰
Dear Daniel, 亲爱的丹尼尔，
Greetings! 问候！
Any thoughts/any other information on using Cyber Knife for treating adrenal cancer aside from using MBZ?
除了使用 MBZ 之外，还有什么关于使用 Cyber Knife 治疗肾上腺癌的想法/其他信息吗？
Thank you very much.
非常感谢。
Best Regards, 此致，
Vic 维克
Dear Vic, 亲爱的维克，
When was the tumor found? What size? What stage? How was treated so far (e.g. Mitotane, chemo, surgery?) and if any, what was the response to that?
肿瘤是什么时候发现的？有多大？处于哪个阶段？目前接受过哪些治疗（例如米托坦、化疗、手术？）？如果有治疗，效果如何？
Have you seen this? https://www.cancertreatmentsresearch.com/acc-adrenocortical/
你看过这个吗？ https://www.cancertreatmentsresearch.com/acc-adrenocortical/
Kind regards, 亲切的问候，
Daniel 丹尼尔
Dear Daniel, 亲爱的丹尼尔，
It was found out earlier this month. Sad to say that it has already metastasized on her lungs and liver. The treatment hasn’t started yet. They are still waiting for the results of the bone scan. Yes sir, I have read the article. I’ll be sharing it to them.
本月初发现的。很遗憾，癌细胞已经转移到她的肺部和肝脏。治疗还没开始。他们还在等骨扫描的结果。是的，先生，我已经读过这篇文章了。我会分享给他们的。
I emailed Dr. Pan Pantziarka, one of the authors of Repurposing Drugs in Oncology (ReDO)—mebendazole as an anti-cancer agent and the Programme Director Drug Repurposing at anticancerfund.org, he mentioned that they might be able to help in assessing the case and maybe give advise to the oncologist based on their findings.
我给 Pan Pantziarka 博士发了一封电子邮件，他是《肿瘤药物再利用》（ReDO）的作者之一，将甲苯咪唑用作抗癌剂，也是 anticancerfund.org 药物再利用项目主任，他提到他们可能能够帮助评估病例，并可能根据他们的发现为肿瘤学家提供建议。
Thanks to you and this blog, I was able to connect with shaneclark as well. I was able to receive very useful information about his regimen that might help later on.
感谢你和这个博客，让我有机会和 Shaneclark 取得联系。我了解到了很多关于他养生法的实用信息，这些对以后的康复可能很有帮助。
Sir, if I may ask for your email so I can share it to the patient so she can connect with you. My email is victorjanedwards@gmail.com.
先生，请问您可以提供您的邮箱地址吗？这样我就可以分享给这位病人，方便她联系您。我的邮箱是 victorjanedwards@gmail.com 。
Thank you very much. 非常感谢。
Regards, 问候，
Vic 维克
Hi Victor, 嗨，维克多，
Thanks for the info. This is an aggressive cancer so the patient and doctors will need to move fast in terms of considering options and starting their application. I like anticancerfund and it’s a good idea to be in contact with them, indeed. My contact details are here https://www.cancertreatmentsresearch.com/contact/ but I prefer to discuss here and not on private e-mails so that others can benefit from the discussions, unless there are details that have to be kept private.
谢谢你的信息。这是一种恶性肿瘤，所以患者和医生需要尽快考虑治疗方案并开始申请。我喜欢抗癌基金，与他们联系确实是一个好主意。我的联系方式在这里 ：https://www.cancertreatmentsresearch.com/contact/ ，但我更愿意在这里讨论，而不是通过私人邮件，这样其他人也能从讨论中受益，除非有需要保密的细节。
Kind regards, 亲切的问候，
Daniel 丹尼尔
Hi Daniel, 嗨，丹尼尔，
Thanks a lot. I’ll update as soon as I can.
非常感谢。我会尽快更新。
Regards, 问候，
Vic 维克
Hi Daniel, 嗨，丹尼尔，
Just a follow up question, are there any interactions between mitotane and mebendazole?as well as with Cimetidine and Glutamine?
只是一个后续问题，米托坦和甲苯咪唑之间有相互作用吗？以及与西咪替丁和谷氨酰胺之间有相互作用吗？
Any thoughts on these? 对此有什么想法吗？
1)Adrenocortical Carcinoma Treated by CyberKnife – https://www.ncbi.nlm.nih.gov/pubmed/27477410
1) 射波刀治疗肾上腺皮质癌 - https://www.ncbi.nlm.nih.gov/pubmed/27477410
2)Treating Adrenal Tumors in 26 Patients with CyberKnife: A Mono-Institutional Experience -https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835566/
2) 使用 CyberKnife 治疗 26 名肾上腺肿瘤患者：单一机构经验 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835566/
Thanks again. 再次感谢。
Best Regards, 此致，
Vic 维克
HI Victor, 嗨，维克多，
There are no known interaction between the two according to https://reference.medscape.com/drug-interactionchecker?src=google
根据 https://reference.medscape.com/drug-interactionchecker?src=google ，两者之间没有已知的相互作用
The only issue is related to Mitotane which is very toxic – adding other drugs, even those with very low toxicity like Mebendazole, may be challenging in the context of Mitotane.
唯一的问题与米托坦有关，因为米托坦毒性很强——在米托坦的背景下添加其他药物，即使是毒性很低的药物，如甲苯咪唑，也可能具有挑战性。
As you probably know, Mitotane is the only treatment officially approved for adreno cortical carcinoma https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182924/, while it’s role in prolonging survival is highly debatable. I know doctors who are even suggesting to their patients not to use it …
你可能知道，米托坦是唯一一种官方批准用于治疗肾上腺皮质癌的药物 （https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182924/ ），但它在延长生存期方面的作用却备受争议。我知道有些医生甚至建议病人不要使用它……
I would not use Glutamine.
我不会使用谷氨酰胺。
The CiberKnife option looks very good to me and I will add this option to the ACC page. Combining CiberKnife with strategies to enhance the activity of the immune system and/or metabolic strategies and/or pH strategy (https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/) and/or reducing intracellular antioxidant production (e.g. with Auranofin) would help.
我觉得 CiberKnife 方案非常不错，我会把它添加到 ACC 页面。将 CiberKnife 与增强免疫系统活性和/或代谢和/或 pH 策略（ https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/ ）和/或减少细胞内抗氧化剂生成（例如使用 Auranofin）相结合，可能会有所帮助。
Actually I think Auranofin may help a lot if the patient has a functional tumor leading to high levels of DHEA – the combo of two will strongly affect the cancer cells and make them more susceptible to radio and chemo.
实际上，我认为如果患者患有功能性肿瘤并导致脱氢表雄酮 (DHEA) 水平升高，那么金诺芬 (Auranofin) 可能会有很大帮助——两者的结合将强烈影响癌细胞，使它们更容易受到放射和化疗的影响。
If the patient has high levels of Cortisol, leading to increased heart rate and blood pressure, Propranolol will help a lot in my experience. And it comes with good anti cancer effects.
如果患者的皮质醇水平高，导致心率加快、血压升高，根据我的经验， 普萘洛尔会很有帮助。而且它还具有良好的抗癌效果。
Kind regards, 亲切的问候，
Daniel 丹尼尔
Dear Daniel, 亲爱的丹尼尔，
Thanks again for all your valuable inputs. Currently checking out hospitals that offers CyberKnife .
再次感谢您的宝贵意见。我目前正在查找提供 CyberKnife 的医院。
You’re a blessing. 你真是一种祝福。
Kind Regards, 亲切的问候，
Vic 维克
Hi Victor, 嗨，维克多，
Great! When you have more info on Cyberknife locations that are willing to treat ACC, please share that on the ACC page too so that other can make use of that info https://www.cancertreatmentsresearch.com/acc-adrenocortical/ Thank you.
太棒了！如果您有更多关于 Cyberknife 诊所的信息，并且这些诊所愿意治疗 ACC，也请分享在 ACC 页面上，以便其他人也能利用这些信息。https ://www.cancertreatmentsresearch.com/acc-adrenocortical/ 谢谢。
Kind regards, 亲切的问候，
Daniel 丹尼尔
Dear Daniel and Viewers of the post,
亲爱的 Daniel 和文章的读者们，
First of all, thank Daniel for this wonderful website and the introduction about mebendazole. I feel our experience may help others who is considering using mebendazole to fight cancer.
首先，感谢 Daniel 创建了这个很棒的网站，并介绍了甲苯咪唑。我觉得我们的经验或许能帮助其他正在考虑使用甲苯咪唑抗癌的人。
My son (14) was enrolled in the mebendazole trial for pediatric brain tumor of Johns Hopkins Hospital. His high grade brain tumor progressed again before he was enrolled in the trial.
我儿子（14岁）参加了约翰·霍普金斯医院的甲苯咪唑治疗儿童脑瘤的试验。在参加试验之前，他的高级别脑瘤再次出现进展。
The trial is a phase 1 trial, the goal is to test the safety and highest tolerable dose of mebendazole for kids. My son was the first to take the highest dose: 4.5 grams/day.
这项试验是一期临床试验，目的是测试甲苯咪唑对儿童的安全性和最高耐受剂量。我儿子是第一个服用最高剂量的：4.5克/天。
He took three 500 mg orange flavored chewable pills at breakfast, at lunch, and at dinner, respectively. This lasted for two months. In the second month, I grinded the pills into powder and mix the powder with olive or sesame oil and milk to help the mebendazole absorption.
他早餐、午餐和晚餐分别服用三粒500毫克的橙味咀嚼片。这样持续了两个月。第二个月，我把药片磨成粉，然后与橄榄油或芝麻油和牛奶混合，以帮助甲苯咪唑的吸收。
My son’s trial stopped when the MRI showed tumor progression two months later. Blood tests were done every two weeks.
两个月后，核磁共振成像显示肿瘤进展，我儿子的试验就停止了。每两周进行一次血液检查。
Side effect: decreased appetite and a little fatigue, nothing major. His blood work was not significantly changed during the two months.
副作用：食欲下降，略有疲劳，但没什么大碍。两个月内，他的血液检查结果没有明显变化。
Effectiveness: unclear, but it was not enough to halt the tumor progression.
有效性：不清楚，但不足以阻止肿瘤进展。
I talked with one of the researchers who discovered the effectiveness of mebendazole on mouse brain tumor model. He mentioned the adult trial was done but not very successful.
我和一位发现甲苯咪唑对小鼠脑瘤模型有效的研究人员聊过。他提到，成人试验已经进行过，但效果并不理想。
The major problem is that unlike in mouse the mebendazole concentration in the blood could be really high, in human, the mebendazole concentration is only about 1 to 10% that in mouse.
主要问题是，与小鼠不同，人类血液中的甲苯咪唑浓度可能非常高，而人类的甲苯咪唑浓度仅为小鼠的 1% 到 10%。
They froze the blood samples to analyze in batches, so I don’t know the blood concentration of mebendazole in my son.
他们把血液样本冷冻起来分批进行分析，所以我不知道儿子体内甲苯咪唑的血液浓度。
In summary, the mebendazole was safe to use as high as 4.5 grams daily for two months without severe side effects for my son. Unfortunately, it was not effective to halt my son’s tumor progression.
总而言之，每天服用高达4.5克的甲苯咪唑，连续服用两个月，对我儿子来说都是安全的，没有出现严重的副作用。可惜的是，它未能有效阻止我儿子的肿瘤进展。
This does not means that mebendazole will not work for other cancers, however, a formulation to increase its absorption is likely critical.
这并不意味着甲苯咪唑对其他癌症无效，然而，增加其吸收的配方可能至关重要。
Dear Jeff, 亲爱的杰夫，
Thank you so much for this very helpful report!
非常感谢您提供这份非常有用的报告！
This is greatly appreciated and will help others in having a reference point on the safety and tolerability of Mebendazole in humans at high dose.
我们对此深表感谢，这将帮助其他人对高剂量甲苯咪唑对人类的安全性和耐受性有一个参考。
Indeed, unfortunately Mebendazole has a poor absorption in humans and fatty food and Cimetidine could somewhat improve that.
确实，不幸的是甲苯咪唑在人体和油腻食物中的吸收率很差，而西咪替丁可以在一定程度上改善这种情况。
If would start a clinical trial on Mebendazole, I would probably start with gastro-intestinal cancers while brain tumors would be some of the last I would consider since besides the absorption barrier there is also BBB barrier standing against Mebendazole and the brain tumors.
如果要开始对甲苯咪唑进行临床试验，我可能会从胃肠道癌症开始，而脑肿瘤将是我最后考虑的，因为除了吸收障碍之外，还有 BBB 屏障阻碍甲苯咪唑和脑肿瘤。
Thank you so much dear Jeff and if I can help with anything please let me know.
非常感谢亲爱的杰夫，如果我能提供任何帮助，请告诉我。
Kind regards, 亲切的问候，
Daniel 丹尼尔
Jeff, do you know how the Hopkins doctors got their supply of the 500 mg mebendazole tablets? I have had a hard time finding a reputable supplier…perhaps going straight to the supplier?
杰夫，你知道霍普金斯的医生是怎么弄到500毫克甲苯咪唑片的吗？我一直很难找到信誉良好的供应商……或许可以直接联系供应商？
Jeff, did you try any combinations? There was strong synergy reported with Fenbendazole and DCA (and also with 2-DG).
杰夫，你试过什么组合吗？据报道，芬苯达唑和 DCA（以及 2-DG）有很强的协同作用。
Metabolic approaches typically need to be done in combination to show their full potential.
代谢方法通常需要结合使用才能发挥其全部潜力。
Often in clinical trials they do not want people trying combos because they are only interested in monotherapy.
在临床试验中，他们通常不希望人们尝试组合疗法，因为他们只对单一疗法感兴趣。
Yet, many metabolic treatments are not effective when only given as mono. Clinical trials can waste decades and decades attempting monotherapy treatments that will never be effective.
然而，许多代谢疾病的治疗方案单药治疗往往无效。临床试验可能会浪费数十年时间，用于尝试永远不会有效的单一疗法。
After all of these years of failure, they pretend that it is some great surprise that there was a lack of efficacy. This is not surprising in the least. It is exactly what would be expected.
这么多年失败了，他们却假装对缺乏效力感到意外。这根本不奇怪，完全在意料之中。
We have seen this numerous times, with drugs such as 3-BP, E260 etc.. These are massively powerful treatments; perhaps some of the most powerful anti-cancer treatments ever found, though when given as monotherapy they can produce disappointing results.
我们已经多次看到过这种情况，例如 3-BP、E260 等药物。这些都是非常有效的治疗方法；也许是迄今为止发现的最有效的抗癌治疗方法，但如果作为单一疗法使用，它们可能会产生令人失望的结果。
Unsurprisingly, alternative clinics that can combine various alternative approaches have reported very impressive results.
毫不奇怪，能够结合各种替代方法的替代诊所报告了非常令人印象深刻的结果。
Good morning everyone, 大家早上好，
Is there any problem to take simultaneously(without rotating as COC suggest) mebendazole/febendazole without cancelling any benefits from taking them?
同时服用甲苯咪唑/非苯咪唑（不按 COC 建议轮换服用）且不抵消服用它们带来的任何益处，这是否有问题？
Kind Regards, 亲切的问候，
Inaki 狒狒
Good afternoon Inaki, 下午好，Inaki，
I see no reason why they would cancel the benefit of each other.
我看不出他们有什么理由要取消彼此的利益。
Kind regards, 亲切的问候，
Daniel 丹尼尔
I appreciate your opinion,
我很欣赏你的意见，
Have a good day 🙂
祝你有美好的一天
Clinical Safety and Efficacy Study of Mebendazole on GI Cancer or Cancer of Unknown Origin.
甲苯咪唑治疗胃肠道癌或不明原因癌的临床安全性和有效性研究。
https://clinicaltrials.gov/ct2/show/NCT03628079
Terminated on Jan 22, 2020 (Lack of effect)
2020年1月22日终止（无效）
Thanks Johan, This is the reasons why I would use it as a part of more extensive treatment strategy and not as stand alone (there are a few cases where it did worked alone, but I would not take the risk to only use this one – same as with Fenbendazole and others.
谢谢 Johan，这就是为什么我会将它作为更广泛的治疗策略的一部分而不是单独使用的原因（在某些情况下它确实可以单独起作用，但我不会冒险只使用这一种——就像芬苯达唑和其他药物一样）。
Btw, is there any published study on this so that we understand how many patients they had? I guess very few would go on Mebendazole alone in a conventional setting.
顺便问一下，有没有这方面的已发表研究，能让我们了解他们治疗了多少病人？我猜在常规情况下，很少有人会单独使用甲苯咪唑。
Kind regards, 亲切的问候，
Daniel 丹尼尔
Hi Daniel, it was only recently terminated (Jan 22) so I guess there will be more information later, the study was with 11 patients in Sweden.
你好，丹尼尔，这项研究最近才终止（1 月 22 日），所以我想稍后会有更多信息，这项研究是在瑞典针对 11 名患者进行的。
Regards, 问候，
Johan 约翰
can someone tell me mum has pancreatic and liver cancer i see this helps pancreatic but no mention of liver cancer and am wondering is it safe to use with liver cancer?
有人能告诉我妈妈患有胰腺癌和肝癌吗？我知道这对治疗胰腺癌有帮助，但没有提到肝癌，我想知道它对治疗肝癌是否安全？
Hi Dan, 嗨，丹，
I am sorry to hear that. I believe you mean your mom has pancreatic cancer with liver metastasis? I am not aware of any major safety issues related to Mebendazole used by patients with liver metastasis. You may also want to read the posts here https://www.cancertreatmentsresearch.com/community/pancreatic-cancer/
听到这个消息我很难过。我想你的意思是你妈妈得了胰腺癌肝转移？我不清楚肝转移患者使用甲苯咪唑存在什么重大安全问题。你也可以看看这里的帖子 ：https://www.cancertreatmentsresearch.com/community/pancreatic-cancer/
Kind regards, 亲切的问候，
Daniel 丹尼尔
thanks dan will check it, the oncologist said the scan showed some anomalies a spot on what is left of her pancreas (most removed last year due to cancer) and a few spots on her liver and he thinks it has returned fast (chemo finished nov last) and no treatment thanks to this virus until it lifts.
谢谢丹，他会检查的，肿瘤科医生说扫描显示她的胰腺剩余部分存在一些异常（去年因癌症切除了大部分），肝脏上也有一些斑点，他认为她的肝脏恢复得很快（化疗于去年 11 月结束），由于这种病毒，在它消失之前无需治疗。
i have read about cystiene and glutamine and glutathione conversion process and the pancreatic cancer is partly glucose and partly glutathione powered so starving it via cysteine reduction was part of my plan i know that metformin lowers IGF-1 which in turn lowers cystiene which in turn reduces glutathione conversion semi starving the pancreatic cancer (your link about Sulfasalazine at a quick glance seems to do the same so i shall check it properly).
我读过关于胱氨酸、谷氨酰胺和谷胱甘肽转化过程的文章，胰腺癌部分由葡萄糖和部分谷胱甘肽提供能量，因此通过减少半胱氨酸来使其挨饿是我的计划的一部分，我知道二甲双胍会降低 IGF-1，从而降低胱氨酸，进而降低谷胱甘肽的转化，使胰腺癌半挨饿（你关于柳氮磺吡啶的链接乍一看似乎也有同样的效果，所以我会仔细检查一下）。
as for the liver cancer i need to know what that uses for fuel i guess fat and glucose?
至于肝癌，我需要知道它使用什么作为燃料，我猜是脂肪和葡萄糖？